Gadolinium(III) hydroxide

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Gadolinium(III) hydroxide
Gadolinium(III) hydroxide.png
Names
Systematic IUPAC name
Gandolinium trihydroxide
Other names
  • Gandolinium(III) hydroxide
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.036.817 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 240-516-5
PubChem CID
  • InChI=1S/Gd.3H2O/h;3*1H2/q+3;;;/p-3
    Key: ILCLBMDYDXDUJO-UHFFFAOYSA-K
  • [OH-].[OH-].[OH-].[Gd+3]
Properties
Gd(OH)3
Molar mass 208.3 g/mol
AppearanceWhite solid
Melting point 307 °C (585 °F; 580 K) [1] (decomposes)
Insoluble
Structure
Hexagonal [2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Gadolinium(III) hydroxide is a chemical compound with the formula Gd(OH)3. Its nanoparticles has a potential use for layering various drugs, such as diclofenac, ibuprofen, and naproxen.

Contents

Production and properties

Gadolinium(III) hydroxide can be produced in various ways such as the reaction of gadolinium(III) nitrate and sodium hydroxide: [1]

Gd(NO3)3 + NaOH → Gd(OH)3 + NaNO3

If this compound is heated to 307 °C, it decomposes to gadolinium(III) oxide-hydroxide(GdOOH), which in turn decomposes to gadolinium(III) oxide if continually heated. [1]

Uses

Gadolinium(III) hydroxide has no commercial uses. However, gadolinium(III) hydroxide nanoparticles have gained interest as a coating agent for various anti-inflammatory drugs such as diclofenac, ibuprofen, and naproxen [3] due to their property to be non-cytotoxic. [4] The nanoparticles are produced by adding base anion exchange resin to gadolinium(III) nitrate. [2]

Related Research Articles

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References

  1. 1 2 3 Logvinenko, V.; Bakovets, V.; Trushnikova, L. (2014). "Dehydroxylation kinetics of gadolinium hydroxide". Journal of Thermal Analysis and Calorimetry. 115 (1): 517–521. doi:10.1007/s10973-013-3274-1. S2CID   97056121.
  2. 1 2 Y. Kobayashi; H. Morimoto; T. Nakagawa; Y. Kubota; K.Gonda; N. Ohuchi (2016). "Fabrication of gadolinium hydroxide nanoparticles using ion-exchange resin and their MRI property". Journal of Asian Ceramic Societies. 4 (1): 138–142. doi: 10.1016/j.jascer.2016.01.005 . S2CID   101542680.
  3. Yadong Xu; Alvaro Goyanes; Yuwei Wang; Andrew J. Weston; Po-Wah So; Carlos F. G. C. Geraldes; Andrew M. Fogg; Abdul W. Basit; Gareth R. Williams (2018). "Layered gadolinium hydroxides for simultaneous drug delivery and imaging". Dalton Transactions. 47 (9): 3166–3177. doi:10.1039/C7DT03729E. PMID   29355263. S2CID   3577750.
  4. Hemmer, Eva; Kohl, Yvonne; Colquhoun, Victoria; Thielecke, Hagen; Soga, Kohei; Mathur, Sanjay (2010). "Probing Cytotoxicity of Gadolinium Hydroxide Nanostructures". The Journal of Physical Chemistry B. 114 (12): 4358–4365. doi:10.1021/jp911607h. PMID   20218658.