Aluminium hydroxide

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Aluminium hydroxide
Gibbsite-crystal-3D-balls.png
Hydroxid hlinity.PNG
Names
Preferred IUPAC name
Aluminium hydroxide
Systematic IUPAC name
Trihydroxidoaluminium
Other names
  • Aluminic acid
  • Aluminic hydroxide
  • Alumanetriol
  • Aluminium(III) hydroxide
  • Aluminium hydroxide
  • Aluminium trihydroxide
  • Hydrated alumina
  • Orthoaluminic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.040.433 OOjs UI icon edit-ltr-progressive.svg
KEGG
PubChem CID
RTECS number
  • BD0940000
UNII
  • InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3 Yes check.svgY
    Key: WNROFYMDJYEPJX-UHFFFAOYSA-K
    A02AB02 ( WHO ) (algeldrate) X mark.svgN
  • InChI=1/Al.3H2O/h;3*1H2/q+3;;;/p-3
    Key: WNROFYMDJYEPJX-DFZHHIFOAJ
  • [OH-].[OH-].[OH-].[Al+3]
Properties [1] [2]
Al(OH)3
Molar mass 78.003 g·mol−1
AppearanceWhite amorphous powder
Density 2.42 g/cm3, solid
Melting point 300 °C (572 °F; 573 K)
0.0001 g/(100 mL)
3×10−34
Solubility soluble in acids and alkalis
Acidity (pKa)>7
Isoelectric point 7.7
Thermochemistry [3]
−1277 kJ·mol−1
Pharmacology [4]
A02AB01 ( WHO )
Hazards
GHS labelling:
no GHS pictograms
no hazard statements
P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313
NFPA 704 (fire diamond)
NFPA 704.svgHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
0
0
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
>5000 mg/kg (rat, oral)
Safety data sheet (SDS) External MSDS
Related compounds
Other anions
None
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)

Aluminium hydroxide, Al(OH)3, is found in nature as the mineral gibbsite (also known as hydrargillite) and its three much rarer polymorphs: bayerite, doyleite, and nordstrandite. Aluminium hydroxide is amphoteric, i.e., it has both basic and acidic properties. Closely related are aluminium oxide hydroxide, AlO(OH), and aluminium oxide or alumina (Al2O3), the latter of which is also amphoteric. These compounds together are the major components of the aluminium ore bauxite. Aluminium hydroxide also forms a gelatinous precipitate in water.

Structure

Al(OH)3 is built up of double layers of hydroxyl groups with aluminium ions occupying two-thirds of the octahedral holes between the two layers. [5] [6] Four polymorphs are recognized. [7] All feature layers of octahedral aluminium hydroxide units, with hydrogen bonds between the layers. The polymorphs differ in terms of the stacking of the layers. All forms of Al(OH)3 crystals are hexagonal [ disputed ]:

Hydrargillite, once thought to be aluminium hydroxide, is an aluminium phosphate. Nonetheless, both gibbsite and hydrargillite refer to the same polymorphism of aluminium hydroxide, with gibbsite used most commonly in the United States and hydrargillite used more often in Europe. Hydrargillite is named after the Greek words for water (hydra) and clay (argylles).[ citation needed ]

Properties

Aluminium hydroxide is amphoteric. In acid, it acts as a Brønsted–Lowry base. It neutralizes the acid, yielding a salt: [9]

3 HCl + Al(OH)3 → AlCl3 + 3 H2O

In bases, it acts as a Lewis acid by binding hydroxide ions: [9]

Al(OH)3 + OH[Al(OH)4]

Production

Red mud reservoirs (this one in Stade, Germany) contain the corrosive residues from the production of aluminium hydroxide. Butzflethermoor Rotschlammdeponie Luftaufnahmen 2012-05-by-RaBoe-478-1.jpg
Red mud reservoirs (this one in Stade, Germany) contain the corrosive residues from the production of aluminium hydroxide.

Virtually all the aluminium hydroxide used commercially is manufactured by the Bayer process [10] which involves dissolving bauxite in sodium hydroxide at temperatures up to 270 °C (518 °F). The waste solid, bauxite tailings, is removed and aluminium hydroxide is precipitated from the remaining solution of sodium aluminate. This aluminium hydroxide can be converted to aluminium oxide or alumina by calcination.[ citation needed ]

The residue or bauxite tailings, which is mostly iron oxide, is highly caustic due to residual sodium hydroxide. It was historically stored in lagoons; this led to the Ajka alumina plant accident in 2010 in Hungary, where a dam bursting led to the drowning of nine people. An additional 122 sought treatment for chemical burns. The mud contaminated 40 square kilometres (15 sq mi) of land and reached the Danube. While the mud was considered non-toxic due to low levels of heavy metals, the associated slurry had a pH of 13. [11]

Uses

Filler and fire retardant

Aluminium hydroxide finds use as a fire retardant filler for polymer applications. It is selected for these applications because it is colorless (like most polymers), inexpensive, and has good fire retardant properties. [12] Magnesium hydroxide and mixtures of huntite and hydromagnesite are used similarly. [13] [14] [15] [16] [17] It decomposes at about 180 °C (356 °F), absorbing a considerable amount of heat in the process and giving off water vapour.

In addition to behaving as a fire retardant, it is very effective as a smoke suppressant in a wide range of polymers, most especially in polyesters, acrylics, ethylene vinyl acetate, epoxies, polyvinyl chloride (PVC) and rubber. [18]

Aluminium hydroxide is used as filler in some artificial stone compound material, often in acrylic resin.[ citation needed ]

Precursor to Al compounds

Aluminium hydroxide is a feedstock for the manufacture of other aluminium compounds: calcined aluminas, aluminium sulfate, polyaluminium chloride, aluminium chloride, zeolites, sodium aluminate, activated alumina, and aluminium nitrate. [6]

Freshly precipitated aluminium hydroxide forms gels, which are the basis for the application of aluminium salts as flocculants in water purification. This gel crystallizes with time. Aluminium hydroxide gels can be dehydrated (e.g. using water-miscible non-aqueous solvents like ethanol) to form an amorphous aluminium hydroxide powder, which is readily soluble in acids. Heating converts it to activated aluminas, which are used as desiccants, adsorbent in gas purification, and catalyst supports. [12]

Pharmaceutical

Under the generic name "algeldrate", aluminium hydroxide is used as an antacid in humans and animals (mainly cats and dogs). It is preferred over other alternatives such as sodium bicarbonate because Al(OH)3, being insoluble, does not increase the pH of stomach above 7 and hence, does not trigger secretion of excess acid by the stomach. Brand names include Alu-Cap, Aludrox, Gaviscon or Pepsamar. It reacts with excess acid in the stomach, reducing the acidity of the stomach content, [19] [20] which may relieve the symptoms of ulcers, heartburn or dyspepsia. Such products can cause constipation, because the aluminium ions inhibit the contractions of smooth muscle cells in the gastrointestinal tract, slowing peristalsis and lengthening the time needed for stool to pass through the colon. [21] Some such products are formulated to minimize such effects through the inclusion of equal concentrations of magnesium hydroxide or magnesium carbonate, which have counterbalancing laxative effects. [22]

This compound is also used to control hyperphosphatemia (elevated phosphate, or phosphorus, levels in the blood) in people and animals suffering from kidney failure. Normally, the kidneys filter excess phosphate out from the blood, but kidney failure can cause phosphate to accumulate. The aluminium salt, when ingested, binds to phosphate in the intestines and reduce the amount of phosphorus that can be absorbed. [23] [24]

Precipitated aluminium hydroxide is included as an adjuvant in some vaccines (e.g. anthrax vaccine). One of the well-known brands of aluminium hydroxide adjuvant is Alhydrogel, made by Brenntag Biosector. [25] [ full citation needed ][ dead link ] Since it absorbs protein well, it also functions to stabilize vaccines by preventing the proteins in the vaccine from precipitating or sticking to the walls of the container during storage. Aluminium hydroxide is sometimes called "alum", a term generally reserved for one of several sulfates.[ citation needed ]

Vaccine formulations containing aluminium hydroxide stimulate the immune system by inducing the release of uric acid, an immunological danger signal. This strongly attracts certain types of monocytes which differentiate into dendritic cells. The dendritic cells pick up the antigen, carry it to lymph nodes, and stimulate T cells and B cells. [26] It appears to contribute to induction of a good Th2 response, so is useful for immunizing against pathogens that are blocked by antibodies. However, it has little capacity to stimulate cellular (Th1) immune responses, important for protection against many pathogens, [27] nor is it useful when the antigen is peptide-based. [28]

Safety

In the 1960s and 1970s it was speculated that aluminium was related to various neurological disorders, including Alzheimer's disease. [29] [30] Since then, multiple epidemiological studies have found no connection between exposure to environmental or swallowed aluminium and neurological disorders, though injected aluminium was not looked at in these studies. [31] [32] [33]

Neural disorders were found in experiments on mice motivated by Gulf War illness (GWI). Aluminium hydroxide injected in doses equivalent to those administered to the United States military, showed increased reactive astrocytes, increased apoptosis of motor neurons and microglial proliferation within the spinal cord and cortex. [34]

Related Research Articles

<span class="mw-page-title-main">Aluminium</span> Chemical element, symbol Al and atomic number 13

Aluminium is a chemical element; it has symbol Al and atomic number 13. Aluminium has a density lower than that of other common metals, about one-third that of steel. It has a great affinity towards oxygen, forming a protective layer of oxide on the surface when exposed to air. Aluminium visually resembles silver, both in its color and in its great ability to reflect light. It is soft, nonmagnetic, and ductile. It has one stable isotope, 27Al, which is highly abundant, making aluminium the twelfth-most common element in the universe. The radioactivity of 26Al is used in radiometric dating.

<span class="mw-page-title-main">Bauxite</span> Sedimentary rock rich in aluminium

Bauxite is a sedimentary rock with a relatively high aluminium content. It is the world's main source of aluminium and gallium. Bauxite consists mostly of the aluminium minerals gibbsite (Al(OH)3), boehmite (γ-AlO(OH)) and diaspore (α-AlO(OH)), mixed with the two iron oxides goethite (FeO(OH)) and haematite (Fe2O3), the aluminium clay mineral kaolinite (Al2Si2O5(OH)4) and small amounts of anatase (TiO2) and ilmenite (FeTiO3 or FeO.TiO2). Bauxite appears dull in luster and is reddish-brown, white, or tan.

<span class="mw-page-title-main">Hydroxide</span> Chemical compound

Hydroxide is a diatomic anion with chemical formula OH. It consists of an oxygen and hydrogen atom held together by a single covalent bond, and carries a negative electric charge. It is an important but usually minor constituent of water. It functions as a base, a ligand, a nucleophile, and a catalyst. The hydroxide ion forms salts, some of which dissociate in aqueous solution, liberating solvated hydroxide ions. Sodium hydroxide is a multi-million-ton per annum commodity chemical. The corresponding electrically neutral compound HO is the hydroxyl radical. The corresponding covalently bound group –OH of atoms is the hydroxy group. Both the hydroxide ion and hydroxy group are nucleophiles and can act as catalysts in organic chemistry.

<span class="mw-page-title-main">Sodium hydroxide</span> Chemical compound with formula NaOH

Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations Na+ and hydroxide anions OH.

<span class="mw-page-title-main">Aluminium oxide</span> Chemical compound with formula Al2O3

Aluminium oxide (or aluminium(III) oxide) is a chemical compound of aluminium and oxygen with the chemical formula Al2O3. It is the most commonly occurring of several aluminium oxides, and specifically identified as aluminium oxide. It is commonly called alumina and may also be called aloxide, aloxite, or alundum in various forms and applications. It occurs naturally in its crystalline polymorphic phase α-Al2O3 as the mineral corundum, varieties of which form the precious gemstones ruby and sapphire. Al2O3 is significant in its use to produce aluminium metal, as an abrasive owing to its hardness, and as a refractory material owing to its high melting point.

<span class="mw-page-title-main">Gibbsite</span> Form of aluminium hydroxide, mineral

Gibbsite, Al(OH)3, is one of the mineral forms of aluminium hydroxide. It is often designated as γ-Al(OH)3 (but sometimes as α-Al(OH)3). It is also sometimes called hydrargillite (or hydrargyllite).

<span class="mw-page-title-main">Magnesium hydroxide</span> Inorganic compound of formula Mg(OH)2

Magnesium hydroxide is an inorganic compound with the chemical formula Mg(OH)2. It occurs in nature as the mineral brucite. It is a white solid with low solubility in water (Ksp = 5.61×10−12). Magnesium hydroxide is a common component of antacids, such as milk of magnesia.

<span class="mw-page-title-main">Brucite</span> Magnesium hydroxide mineral

Brucite is the mineral form of magnesium hydroxide, with the chemical formula Mg(OH)2. It is a common alteration product of periclase in marble; a low-temperature hydrothermal vein mineral in metamorphosed limestones and chlorite schists; and formed during serpentinization of dunites. Brucite is often found in association with serpentine, calcite, aragonite, dolomite, magnesite, hydromagnesite, artinite, talc and chrysotile.

The Bayer process is the principal industrial means of refining bauxite to produce alumina (aluminium oxide) and was developed by Carl Josef Bayer. Bauxite, the most important ore of aluminium, contains only 30–60% aluminium oxide (Al2O3), the rest being a mixture of silica, various iron oxides, and titanium dioxide. The aluminium oxide must be further purified before it can be refined into aluminium metal.

Aluminium chlorohydrate is a group of water-soluble, specific aluminium salts having the general formula AlnCl3nm(OH)m. It is used in cosmetics as an antiperspirant and as a coagulant in water purification.

<span class="mw-page-title-main">Boehmite</span> Mineral

Boehmite or böhmite is an aluminium oxide hydroxide mineral, a component of the aluminium ore bauxite. It is dimorphous with diaspore. It crystallizes in the orthorhombic dipyramidal system and is typically massive in habit. It is white with tints of yellow, green, brown or red due to impurities. It has a vitreous to pearly luster, a Mohs hardness of 3 to 3.5 and a specific gravity of 3.00 to 3.07. It is colorless in thin section, optically biaxial positive with refractive indices of nα = 1.644 – 1.648, nβ = 1.654 – 1.657 and nγ = 1.661 – 1.668.

<span class="mw-page-title-main">Aluminium sulfate</span> Chemical compound

Aluminium sulfate is a salt with the formula Al2(SO4)3. It is soluble in water and is mainly used as a coagulating agent (promoting particle collision by neutralizing charge) in the purification of drinking water and wastewater treatment plants, and also in paper manufacturing.

<span class="mw-page-title-main">Sodium aluminate</span> Chemical compound

Sodium aluminate is an inorganic chemical that is used as an effective source of aluminium hydroxide for many industrial and technical applications. Pure sodium aluminate (anhydrous) is a white crystalline solid having a formula variously given as NaAlO2, NaAl(OH)4 (hydrated), Na2O·Al2O3, or Na2Al2O4. Commercial sodium aluminate is available as a solution or a solid.
Other related compounds, sometimes called sodium aluminate, prepared by reaction of Na2O and Al2O3 are Na5AlO4 which contains discrete AlO45− anions, Na7Al3O8 and Na17Al5O16 which contain complex polymeric anions, and NaAl11O17, once mistakenly believed to be β-alumina, a phase of aluminium oxide.

<span class="mw-page-title-main">Hydromagnesite</span> Hydrated hydroxy-carbonate mineral of magnesium

Hydromagnesite is a hydrated magnesium carbonate mineral with the formula Mg5(CO3)4(OH)2·4H2O.

In chemistry, an aluminate is a compound containing an oxyanion of aluminium, such as sodium aluminate. In the naming of inorganic compounds, it is a suffix that indicates a polyatomic anion with a central aluminium atom.

<span class="mw-page-title-main">Fire retardant</span> Substance reducing flammability

A fire retardant is a substance that is used to slow down or stop the spread of fire or reduce its intensity. This is commonly accomplished by chemical reactions that reduce the flammability of fuels or delay their combustion. Fire retardants may also cool the fuel through physical action or endothermic chemical reactions. Fire retardants are available as powder, to be mixed with water, as fire-fighting foams and fire-retardant gels. Fire retardants are also available as coatings or sprays to be applied to an object.

Carl Josef Bayer was an chemist from Austria-Hungary who invented the Bayer process of extracting alumina from bauxite, essential to this day to the economical production of aluminium.

Aluminium hydroxide oxide or aluminium oxyhydroxide, AlO(OH) is found as one of two well defined crystalline phases, which are also known as the minerals boehmite and diaspore. The minerals are important constituents of the aluminium ore, bauxite.

<span class="mw-page-title-main">Red mud</span> Waste product from the production of alumina

Red mud, now more frequently termed bauxite residue, is an industrial waste generated during the processing of bauxite into alumina using the Bayer process. It is composed of various oxide compounds, including the iron oxides which give its red colour. Over 95% of the alumina produced globally is through the Bayer process; for every tonne of alumina produced, approximately 1 to 1.5 tonnes of red mud are also produced. Annual production of alumina in 2020 was over 133 million tonnes resulting in the generation of over 175 million tonnes of red mud.

<span class="mw-page-title-main">Aluminium compounds</span>

Aluminium (British and IUPAC spellings) or aluminum (North American spelling) combines characteristics of pre- and post-transition metals. Since it has few available electrons for metallic bonding, like its heavier group 13 congeners, it has the characteristic physical properties of a post-transition metal, with longer-than-expected interatomic distances. Furthermore, as Al3+ is a small and highly charged cation, it is strongly polarizing and aluminium compounds tend towards covalency; this behaviour is similar to that of beryllium (Be2+), an example of a diagonal relationship. However, unlike all other post-transition metals, the underlying core under aluminium's valence shell is that of the preceding noble gas, whereas for gallium and indium it is that of the preceding noble gas plus a filled d-subshell, and for thallium and nihonium it is that of the preceding noble gas plus filled d- and f-subshells. Hence, aluminium does not suffer the effects of incomplete shielding of valence electrons by inner electrons from the nucleus that its heavier congeners do. Aluminium's electropositive behavior, high affinity for oxygen, and highly negative standard electrode potential are all more similar to those of scandium, yttrium, lanthanum, and actinium, which have ds2 configurations of three valence electrons outside a noble gas core: aluminium is the most electropositive metal in its group. Aluminium also bears minor similarities to the metalloid boron in the same group; AlX3 compounds are valence isoelectronic to BX3 compounds (they have the same valence electronic structure), and both behave as Lewis acids and readily form adducts. Additionally, one of the main motifs of boron chemistry is regular icosahedral structures, and aluminium forms an important part of many icosahedral quasicrystal alloys, including the Al–Zn–Mg class.

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