| Lederbergvirus | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Uroviricota |
| Class: | Caudoviricetes |
| Order: | Caudovirales |
| Family: | Podoviridae |
| Genus: | Lederbergvirus |
Lederbergvirus (synonyms P22-like viruses, P22-like phages, P22likevirus) is a genus of viruses in the order Caudovirales , in the family Podoviridae . Bacteria serve as natural hosts, with transmission achieved through passive diffusion. There are six species in this genus. [1] [2] [3]
The following six species are assigned to the genus: [2]
Lederbergviruses are nonenveloped, with a head and tail. The head is icosahedral with T=7 symmetry, with a diameter of approximately 60 to 65 nm. The tail is non-contractile with six prominent tail spikes. [1]
| Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
|---|---|---|---|---|---|
| Lederbergvirus | Head-Tail | T=7 | Non-enveloped | Linear | Monopartite |
Several species have been fully sequenced. They range between 38k and 42k nucleotides, with 58 to 72 proteins. Complete genomes, as well as several similar unclassified strains are available from [3]
Viral replication is cytoplasmic. The virus attaches to the host cell using its terminal fibers, and ejects the viral DNA into the host periplasm. DNA-templated transcription is the method of transcription. Once the viral genes have been replicated, new virions are assembled in the host's cytoplasm, and mature virions are released via lysis and holin/endolysin/spanin proteins. [1]
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Lederbergvirus | Bacteria | None | Injection | Lysis | Cytoplasm | Cytoplasm | Passive diffusion |
According to ICTV's 1996 report, the genus P22likevirus was first accepted under the name P22-like phages, assigned only to family Podoviridae . The whole family was moved to the newly created order Caudovirales in 1998, and the genus was renamed to P22-like viruses in ICTV's seventh report in 1999. In 2012, the genus was renamed again, this time to P22likevirus. [2] The genus was later renamed to Lederbergvirus.
Podoviridae is a family of bacteriophage in the order Caudovirales often associated with T-7 like phages. There are 130 species in this family, assigned to 3 subfamilies and 52 genera. This family is characterized by having very short, noncontractile tails. Podoviradae are largely understudied and most new isolates are of the phicbkviruses genus, a group of giant viruses that appear to be Caulobacter specific.
Caudoviricetes is a class of viruses known as the tailed bacteriophages. Under the Baltimore classification scheme, the Caudoviricetes are group I viruses as they have double stranded DNA (dsDNA) genomes, which can be anywhere from 18,000 base pairs to 500,000 base pairs in length. The virus particles have a distinct shape; each virion has an icosahedral head that contains the viral genome, and is attached to a flexible tail by a connector protein. The order encompasses a wide range of viruses, many containing genes of similar nucleotide sequence and function. However, some tailed bacteriophage genomes can vary quite significantly in nucleotide sequence, even among the same genus. Due to their characteristic structure and possession of potentially homologous genes, it is believed these bacteriophages possess a common origin.
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Ravinvirus is a genus of viruses in the order Caudovirales, in the family Siphoviridae. Bacteria serve as natural hosts, with transmission achieved through passive diffusion. There is only one species in this genus: Escherichia virus N15.
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