PLCD3

PLCD3
Identifiers
Aliases	PLCD3 , PLC-delta-3, phospholipase C delta 3
External IDs	OMIM: 608795; MGI: 107451; HomoloGene: 14858; GeneCards: PLCD3; OMA:PLCD3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 45,108,959 bp [1] End 45,133,354 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 66.71 cM Start 102,961,130 bp [2] End 102,992,484 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon muscle of thigh apex of heart gastric mucosa Descending thoracic aorta right coronary artery buccal mucosa cell left adrenal cortex ascending aorta gastrocnemius muscle Top expressed in neural layer of retina gastrula decidua vestibular membrane of cochlear duct otolith organ utricle morula lip epithelium of lens sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity signal transducer activity metal ion binding phosphoric diester hydrolase activity phosphatidylinositol phospholipase C activity protein binding Cellular component cytosol plasma membrane cleavage furrow membrane cytoplasm intracellular anatomical structure Biological process angiogenesis lipid catabolic process intracellular signal transduction labyrinthine layer blood vessel development inositol phosphate metabolic process regulation of cell population proliferation lipid metabolism signal transduction inositol trisphosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113026 72469 Ensembl ENSG00000161714 ENSMUSG00000020937 UniProt Q8N3E9 Q8K2J0 RefSeq (mRNA) NM_133373 NM_152813 NM_001361706 RefSeq (protein) NP_588614 NP_690026 NP_001348635 Location (UCSC) Chr 17: 45.11 – 45.13 Mb Chr 11: 102.96 – 102.99 Mb PubMed search [3] [4]
Wikidata
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1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP₃). Diacylglycerol and IP₃ mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca²⁺ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000161714 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020937 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 209–10. doi:10.1159/000015469. PMID   10702670. S2CID   87171791.
6. Ghosh S, Pawelczyk T, Lowenstein JM (Mar 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expression and Purification. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID   9056492.
7. "Entrez Gene: PLCD3 phospholipase C, delta 3".

Further reading

• Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (Dec 1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". The Journal of Clinical Investigation. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC   329852 . PMID   1979339.
• Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (Sep 1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". European Journal of Immunology. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID   7589147. S2CID   20562627.
• Chen P, Mayne M, Power C, Nath A (Sep 1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". The Journal of Biological Chemistry. 272 (36): 22385–8. doi: 10.1074/jbc.272.36.22385 . PMID   9278385.
• Pawełczyk T, Matecki A (1998). "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3". Acta Biochimica Polonica. 44 (2): 221–9. doi: 10.18388/abp.1997_4417 . PMID   9360711.
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID   9730685. S2CID   19529677.
• Pawelczyk T, Matecki A (Oct 1998). "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium". European Journal of Biochemistry. 257 (1): 169–77. doi: 10.1046/j.1432-1327.1998.2570169.x . PMID   9799116.
• Pawelczyk T, Matecki A (Jun 1999). "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes". European Journal of Biochemistry. 262 (2): 291–8. doi: 10.1046/j.1432-1327.1999.00388.x . PMID   10336610.
• Haughey NJ, Holden CP, Nath A, Geiger JD (Oct 1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". Journal of Neurochemistry. 73 (4): 1363–74. doi: 10.1046/j.1471-4159.1999.0731363.x . PMID   10501179. S2CID   25410140.
• Mayne M, Holden CP, Nath A, Geiger JD (Jun 2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology. 164 (12): 6538–42. doi: 10.4049/jimmunol.164.12.6538 . PMID   10843712.
• Lin FG, Cheng HF, Lee IF, Kao HJ, Loh SH, Lee WH (Aug 2001). "Downregulation of phospholipase C delta3 by cAMP and calcium". Biochemical and Biophysical Research Communications. 286 (2): 274–80. doi:10.1006/bbrc.2001.5371. PMID   11500033.
• Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W (Feb 2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". The Journal of Biological Chemistry. 277 (5): 3568–75. doi: 10.1074/jbc.M109705200 . PMID   11706040.
• Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi: 10.1093/dnares/8.6.319 . PMID   11853319.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (Nov 2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID   12482669.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.