Poppy straw

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Poppy straw (left) and seeds (right) Poppies-seeds-dry.png
Poppy straw (left) and seeds (right)
Poppy seed heads, pods or capsules Mohn z06.jpg
Poppy seed heads, pods or capsules

Poppy straw (also known as opium straw, mowed opium straw, crushed poppy capsule, poppy chaff, or poppy husk) is derived from opium poppies ( Papaver somniferum ) that are harvested when fully mature and dried by mechanical means. Opium poppy straw is what remains after the seed pods have been harvested - that is, the dried stalks, stem and leaves of poppies grown for their seeds. [1] The field-dried leaves, stalk, and seed pod are then used in commercial manufacture of morphine or other poppy-alkaloid derived drugs, by first processing the material, separating the seeds, and then making concentrate of poppy straw [2] where no extraction using the traditional methods of latex extraction has been made. [3] The straw was originally considered an agricultural by-product of the mechanised poppy seed harvest, which was primarily grown for its edible and oil-producing seed. This changed in 1927 when János Kabay developed a chemical process to extract morphine from the crushed capsule. [2] Concentrated poppy straw, consisting mainly of the crushed capsule without the seeds, [4] soon became a valuable source of morphine. Today, concentrate of poppy straw is a major source of many opiates and other alkaloids. It is the source of 90% of the world supply of legal morphine (for medical and scientific use) [5] and in some countries it also is a source of illegal morphine, which could be processed into illegal heroin. [4]

Contents

The 1961 Single Convention on Narcotic Drugs defines poppy straw as "all parts (except the seeds) of the opium poppy, after mowing". [6]

Decorative dried flower producer/growers and wholesalers [7] hand-pick the decorative mature seeded pods/heads with or without the stalks for use in floral decorative arrangements. These are then mechanically dried at high temperatures in large kilns to render insects dead and the seeds unviable, so that the harvest consists almost entirely of the dried flowered seeded pods/heads (for ease of transport, artificial stems are added afterwards, e.g. bird seed wreath making, floral arrangements and wedding boutonnières or arts/craft projects). The seeds used for this market are chosen for the size and shape of the mature poppy seed pod/head and not alkaloid content.

Many varieties, strains, and cultivars of Papaver somniferum are in existence, and the alkaloid content can vary significantly. [8]

Harvesting

Traditional method: fruits are scored Afghanistan 16.jpg
Traditional method: fruits are scored
Traditional method of harvesting opium by hand, still in use today Harvesting opium.jpg
Traditional method of harvesting opium by hand, still in use today
Modern method; fruits are not scored Papaver somniferum field Tasmania.JPG
Modern method; fruits are not scored
Modern method: harvesting of poppy straw Mohn z11.jpg
Modern method: harvesting of poppy straw

Traditional harvesting of opium poppies to produce opiates involved the labor-intensive work of making shallow cuts in the immature fruits (seed pods) so that the latex would leak out and dry, then returning the following day to scrape off the dry latex, known as raw opium.

Harvesting of poppy straw is an alternative, largely mechanized, method. The plants are allowed to mature fully, then a machine is used to harvest the entire field. The ripe poppy seeds are separated out by threshing and winnowing, and the remainder is poppy straw. Poppy straw usually consists of only the above ground parts of the plant, but the roots may be harvested as well. Some producers mow the plants high, so that the harvest consists almost entirely of the fruits (seed pods), omitting the stalks, leaves, and roots. Poppy straw is then processed in a manner similar to opium to extract opiates and other alkaloids (see Morphine).

Avoiding the labor-intensive harvesting of opium by hand was the topic of research for almost 100 years. [9] This research was of notable interest in those countries where opium poppy was an important oilseed crop but where high labor costs made the harvesting of opium uneconomic. What was needed was a process that enabled commercial extraction of opiates from opium poppies directly rather than from (comparatively pure) opium.

By the 1940s, commercial production of morphine from poppy straw had spread from Hungary to Poland and finally to most countries where poppies are grown on a large scale primarily for their seeds. By 1950, about 10% of the poppy seed harvest of those countries was also yielding morphine. Based on average yields and the reported production of poppy seed in nine European countries, the potential production of morphine from those crops was estimated to be 148,800 kilograms (328,000 lb). However, in 1950 the actual production of morphine from poppy straw was reported to be 11,663 kilograms (25,713 lb). [10]

As of 1950, the average annual yield per hectare was estimated to be 675 kilograms (1,488 lb) poppy seed and 450 kilograms (990 lb) poppy straw (dry capsule chaff), which in turn was estimated to yield about 1.5 kilograms (3.3 lb) of morphine (in good years). [10]

Processing

The first commercial process by which opiates are extracted from poppy straw was invented in Hungary by János Kabay. [9] [11] This process, known as the "poppy straw method", [12] remains in use today. Kabay applied his new process initially to fields of opium poppies between the stages of flowering and maturity, while the fruits were green. This had several disadvantages: the immature poppy seeds could not be winnowed, so not only was the seed crop lost but their poppyseed oil interfered with the process; the abundant chlorophyll in the green plants also interfered; and an entire year's crop had to be processed in two months, as it reached the fruit stage. Kabay soon found that the process could be applied to poppy straw residue from the poppy seed harvest, thereby eliminating all these disadvantages.

Poppy straw is first pulverized, then washed as many as six to ten or more times in water which may have an acid added to increase solubility, to produce poppy straw concentrate (PSC, also known as concentrate of poppy straw, CPS). Dried, the concentrate is a beige to brown powder. It contains salts of various alkaloids, and can range from nine to 30 times the morphine concentration of poppy straw. Opium concentrates using solvents other than acidifed or plain water are often but not necessarily called PSC. [13]

Poppies of the Norman and Przemko strains contain much higher amounts of thebaine and oripavine and have morphine concentrations down to under 1% versus up to 26% in high-morphine strains. [14] At least one manufacturer, Tasmanian Alkaloids, produces both high-morphine and high-thebaine/oripavine types of poppy straw concentrate; the latter is used by pharmaceutical manufacturers to make semi-synthetic and synthetic opioids such as hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine, butorphanol and etorphine.

PSC is an alternative to bricks of opium as an alkaloid source in most but not all of the production methods that isolate alkaloids from the opium poppy. A notable exception is thebaine, which is present in far larger fractions in opium than in poppy straw. [15] Morphine, being a large fraction of the alkaloids found in mature poppy capsules, is produced commercially from either opium or concentrated poppy straw. [3] To extract morphine, PSC is dissolved in water and treated with other chemicals to obtain the next intermediate, calcium morphenate (or less frequently sodium morphenate), which is then further treated to purify the drug and convert it to the desired morphine salt or base. Processes for extracting other alkaloids, such as codeine and noscapine, use other pharmaceutical processes.

Poppy straw crops

Annual world production of opium and poppy straw, both legal and illegal, is tabulated by the United Nations Office on Drugs and Crime, and reported in its annual World Drug Report. The quantity of poppy straw produced is typically given as "opium equivalents". The 2002 World Drug Report estimate of the total world opium production, including opium equivalents of poppy straw, was 42,600 metric tons (41,900 long tons) in 1906/07 and 12,600 metric tons (12,400 long tons) in 2007. The 2007 production consisted of 8,870 metric tons (8,730 long tons) of illegal opium, 3,420 metric tons (3,370 long tons) of opium equivalent from legal poppy straw, and 300 metric tons (300 long tons) of legal opium. [5] Thus, over 90% of the world production of legal opiates, including medical morphine, now is produced from poppy straw.

With the establishment of poppy straw as the source of the majority of natural morphine and other opiates, much of the world production of opium is destined for illicit uses. In 1981 dried capsules being sold for decoration in Sweden were found to have been lanced 2 to 5 times with a tool having 3 to 4 blades and the opium scraped off. The morphine content of these capsules was 0.15 - 0.34%, comparable to domestic Swedish capsules not lanced. In India, poppy straw from lanced capsules had a morphine content of at least 0.2%. These levels of morphine obtained from "exhausted" plants suggests that for producers of licit opium, poppy straw may be a profitable second crop. [6]

As of 2005, India was the only country producing licit opium (opium gum) for both domestic use and export. Licit opium was produced also in Democratic People's Republic of Korea for domestic use, and in Japan for maintenance of the pertinent technology (small quantities). Opium poppies were grown principally for extraction of alkaloids (from poppy straw) in 9 other countries: Australia, China, France, Hungary, Slovakia, Spain, the Republic of Macedonia, Turkey, and the United Kingdom. China ceased producing licit opium after 2001. [16] Opium poppies grown principally for the seed crop, with licit poppy straw as a by-product, were produced in the Czech Republic, Serbia and Montenegro. Another 6 countries cultivated opium poppies solely for the poppy seed or horticultural purposes, without extraction of alkaloids from poppy straw: Austria, Estonia, Germany, Netherlands, Poland, and Ukraine. [17] Illicit production of Polish heroin and other products derived from poppy straw is an ongoing problem in Poland, although it isn't as serious as in the 1980s, after poppies containing high levels of opioid alkaloids were banned in 1990s. [4]

The production of licit opium in India was in accord with terms of the 1961 Single Convention on Narcotic Drugs. After the opium was harvested, the plants were allowed to mature and harvested for poppy seeds. The sale of poppy seeds delivered a significant proportion of the income from the licit opium crop. Unknown fractions of both the opium harvest and the poppy straw residue from the poppy seed harvest were diverted to illicit uses. [17]

The production of illegal opium from poppy straw is limited. It is reported primarily in clandestine laboratories in Moldova, the Russian Federation, and Ukraine, using domestic poppy straw. [4]

Derived products

A common method of producing laudanum involves dissolving the PSC or latex-derived opium in alcohol and either allowing the solution to sit for up to a week, being periodically agitated; using fresh alcohol to do multiple washes; or refluxing. The original patents for laudanum in various countries refer to soaking poppy straw with varying levels of pulverisation in plain water for a week then evaporating the water to obtain the gummy or powdery brown concentrate.

Recreational use

Poppy tea and its variants can be said to be an incomplete and/or relatively crude form of PSC aqueous solution.

Home-made poppy straw extracts including Kompot are widely used among IV drug users in eastern Europe, including Ukraine [18] [19] and Poland. [20]

Tracing of illicit drugs

Illegal heroin may be produced using poppy straw as a raw material. The alkaloid profiles of poppy straw and opium are similar, but preliminary research suggests they can be distinguished by relative quantities of alkaloids. [21] Based on the presence of the alkaloid oripavine in some opium poppies, it has been suggested that illegal heroin seized in Australia was produced from a legal poppy straw crop stolen in Tasmania a few years earlier. [22]

Related Research Articles

<span class="mw-page-title-main">Morphine</span> Pain medication of the opiate family

Morphine is a strong opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies. It is mainly used as an analgesic. There are numerous methods used to administer morphine: oral; sublingual; via inhalation; injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are available as MS-Contin, Kadian, and other brand names as well as generically.

<span class="mw-page-title-main">Opium</span> Dried latex obtained from the opium poppy

Opium is dried latex obtained from the seed capsules of the opium poppy Papaver somniferum. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated. The word meconium historically referred to related, weaker preparations made from other parts of the opium poppy or different species of poppies.

<span class="mw-page-title-main">Thebaine</span> Opiate alkaloid constituent of opium

Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai (Thebes), an ancient city in Upper Egypt. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine. While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum and can be converted industrially into a variety of compounds, including hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine, butorphanol and etorphine.

<span class="mw-page-title-main">Narcotic</span> Chemical substance with psycho-active properties

The term narcotic originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiates and opioids, commonly morphine and heroin, as well as derivatives of many of the compounds found within raw opium latex. The primary three are morphine, codeine, and thebaine.

<span class="mw-page-title-main">Poppy</span> Species of flowering plant in the family Papaveraceae

A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, Papaver somniferum, is the source of the narcotic drug mixture opium which contains powerful medicinal alkaloids such as morphine and has been used since ancient times as an analgesic and narcotic medicinal and recreational drug. It also produces edible seeds. Following the trench warfare in the poppy fields of Flanders, Belgium during World War I, poppies have become a symbol of remembrance of soldiers who have died during wartime, especially in the UK, Canada, Australia, New Zealand and other Commonwealth realms.

<i>Papaver somniferum</i> Species of flowering plant in the family Papaveraceae

Papaver somniferum, commonly known as the opium poppy or breadseed poppy, is a species of flowering plant in the family Papaveraceae. It is the species of plant from which both opium and poppy seeds are derived and is also a valuable ornamental plant grown in gardens. Its native range was east of the Mediterranean Sea, but now is obscured by ancient introductions and cultivation, being naturalized across much of Europe and Asia.

<span class="mw-page-title-main">Poppy tea</span> Herbal tea made out of poppy straw or poppy seeds

Poppy tea is an herbal tea infusion brewed from poppy straw or seeds of several species of poppy. The species most commonly used for this purpose is Papaver somniferum, which produces opium as a natural defense against predators. In the live flower, opium is released when the surface of the bulb, called the seed pod, is pierced or scraped. For the purpose of the tea, dried pods are more commonly used than the pods of the live flower. The walls of the dried pods contain opiate alkaloids, primarily consisting of morphine.

<span class="mw-page-title-main">Golden Triangle (Southeast Asia)</span> River confluence that is an opium-producing region in Southeast Asia

The Golden Triangle is the name given to one of Asia's two principal areas of illicit opium production. Its geographical limits are the area in which the borders of Myanmar, Thailand, and Laos meet at the confluence of the Ruak and the Mekong Rivers. The name "Golden Triangle" was coined by the CIA and is commonly used more broadly to refer to an area of approximately 950,000 square kilometres (367,000 sq mi) that overlaps the mountains of the four adjacent countries.

<span class="mw-page-title-main">Opium production in Afghanistan</span> Overview of illicit drug production in Afghanistan

Afghanistan has long had a history of opium poppy cultivation and harvest. As of 2021, Afghanistan's harvest produces more than 90% of illicit heroin globally, and more than 95% of the European supply. More land is used for opium in Afghanistan than is used for coca cultivation in Latin America. The country has been the world's leading illicit drug producer since 2001. In 2007, 93% of the non-pharmaceutical-grade opiates on the world market originated in Afghanistan. By 2019 Afghanistan still produced about 84% of the world market. This amounts to an export value of about US $4 billion, with a quarter being earned by opium farmers and the rest going to district officials, insurgents, warlords, and drug traffickers. In the seven years (1994–2000) prior to a Taliban opium ban, the Afghan farmers' share of gross income from opium was divided among 200,000 families.

Pantopon, also known as Opium Alkaloids Hydrochlorides, is a preparation of opiates made up of all of the alkaloids present in opium in their natural proportions as hydrochlorides salts. It can sometimes be tolerated by people who are allergic to morphine.

<span class="mw-page-title-main">Poppy seed</span> Edible oilseed obtained from poppy

Poppy seed is an oilseed obtained from the opium poppy. The tiny, kidney-shaped seeds have been harvested from dried seed pods by various civilizations for thousands of years. It is still widely used in many countries, especially in Central Europe and South Asia, where it is legally grown and sold in shops. The seeds are used whole or ground into meal as an ingredient in many foods – especially in pastry and bread – and they are pressed to yield poppyseed oil.

"Polish" heroin is a crude preparation of heroin made from poppy straw. It is an opiate, used recreationally as a psychoactive drug. Poppy straw, like opium, is harvested from the opium poppy. Polish heroin was used mainly in Central and Eastern Europe prior to the dissolution of the Soviet Union and the end of communist control of the countries of the Warsaw Pact or Eastern Bloc.

<i>Papaver bracteatum</i> Species of flowering plant

Papaver bracteatum, also known as the Iranian poppy or Persian poppy and the great scarlet poppy is a sturdy hardy perennial poppy with large deep red flowers up to 8 inches (20 cm) in diameter on stiff stalks up to 4 feet high with a prominent black spot near the base of the petals. It is closely related to the commonly cultivated oriental poppy, Papaver orientale and is sometimes recorded as the varietal form Papaver orientale var. bracteatum.

The Government Opium and Alkaloid Factories (GOAF) is an Indian government-owned organisation. Its headquarter is located in New Delhi. The overall supervision of the organisation comes under the purview of Department of Revenue, Ministry of Finance. There are two factories under this organisation - Government Opium and Alkaloid Works, Ghazipur (U.P.) and Government Opium and Alkaloid Works, Neemuch (M.P.).

Legal cultivation of opium for medicinal purposes is carried out in India, only in selected areas, under free licensing conditions. India is the world's largest manufacturer of legal opium for the pharmaceutical industry according to the CIA World Factbook. India is one among 12 countries in world where legal cultivation for medical use is permissible within the ambit of United Nations, Single Convention on Narcotic Drugs 1961. In India legal cultivation is done primarily in Madhya Pradesh, Rajasthan and Uttar Pradesh. Despite producing poppy for opium production India depends heavily on imports to meet need of Poppy seed for edible purposes and domestic Codeine demand for medical purposes . Opium is heavily imported from its top producing nations like Afghanistan. There is also an account of Opium black marketing in India.

<span class="mw-page-title-main">Opiate</span> Substance derived from opium

An opiate, is an alkaloid substance derived from opium It has a different meaning from the similar term opioid, used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain. Opiates are alkaloid compounds naturally found in the opium poppy plant Papaver somniferum. The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Most opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. Some, such as thebaine don't share the same effects and are not classified as controlled substances.

Extractas Bioscience (before called Tasmanian Alkaloids) is the largest opium poppy processing company in the Australian state of Tasmania. Approximately forty percent of the world's legal opiate crop is grown in Tasmania. Tasmanian Alkaloids was a subsidiary of the United States pharmaceutical company Johnson & Johnson, but was formerly—as of 1980—a subsidiary of Abbott Laboratories.

<i>Papaver glaucum</i> Species of flowering plant in the poppy family Papaveraceae

Papaver glaucum, the tulip poppy, Turkish tulip or Turkish red poppy, is a poppy found in the region of Anatolia.

<span class="mw-page-title-main">Tasmanian opium poppy farming industry</span>

The Tasmanian opium poppy farming industry was established in Tasmania in 1966.

<span class="mw-page-title-main">Salutaridinol</span> Chemical compound

Salutaridinol is a modified benzyltetrahydroisoquinoline alkaloid with the formula C19H23NO4. It is produced in the secondary metabolism of the opium poppy Papaver somniferum (Papaveraceae) as an intermediate in the biosynthetic pathway that generates morphine. As an isoquinoline alkaloid, it is fundamentally derived from tyrosine as part of the shikimate pathway of secondary metabolism. Salutaridinol is a product of the enzyme salutaridine: NADPH 7-oxidoreductase and the substrate for the enzyme salutaridinol 7-O-acetyltransferase, which are two of the four enzymes in the morphine biosynthesis pathway that generates morphine from (R)-reticuline. Salutaridinol's unique position adjacent to two of the four enzymes in the morphine biosynthesis pathway gives it an important role in enzymatic, genetic, and synthetic biology studies of morphine biosynthesis. Salutaridinol levels are indicative of the flux through the morphine biosynthesis pathway and the efficacy of both salutaridine: NADPH 7-oxidoreductase and salutaridinol 7-O-acetyltransferase.

References

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  2. 1 2 Bernáth, Jenő (1998). Poppy the genus Papaver (2000 eBook ed.). Amsterdam, the Netherlands: Harwood Academic Publishers. p. vii. ISBN   978-0-203-30418-1 . Retrieved 16 July 2015.
  3. 1 2 Freemantle, Michael (2005). "The Top Pharmaceuticals That Changed The World: Morphine". Chemical and Engineering News. 83 (25).
  4. 1 2 3 4 World Drug Report. United Nations Office on Drugs and Crime. 2009. p. 37.
  5. 1 2 "Achievements and unintended consequences of the international drug control system" (PDF). World Drug Report. United Nations Office on Drugs and Crime. 2008. p. 213.
  6. 1 2 Bruhn, J. G.; Nyman, U. (1981). "A note on the morphine content of lanced poppy capsules purchased as "dried flowers"". Bulletin on Narcotics. 33 (2): 41–44. PMID   6914204.
  7. ↑ "Image collection / RHS Gardening". Archived from the original on 2011-05-24. Retrieved 2011-03-07.
  8. ↑ "Bureau voor Medicinale Cannabis | Pagina niet gevonden" (PDF). Cannabisbureau.nl. 2013-03-19. Archived from the original (PDF) on 2013-01-20. Retrieved 2013-09-01.
  9. 1 2 Bayer, Istvan (1961). "Manufacture of alkaloids from the poppy plant in Hungary". Bulletin on Narcotics. 13 (1): 21–28.
  10. 1 2 Anonymous (1953). "The manufacture of morphine from poppy straw". Bulletin on Narcotics (3): 16–18.
  11. ↑ Bayer I (July 1987). "[János Kabay and the poppy straw process. Commemoration on the 50th anniversary of his death]". Acta Pharmaceutica Hungarica (in Hungarian). 57 (3–4): 105–10. PMID   3314338.
  12. ↑ "1. The world drug problem: A status report". World Drug Report. United Nations Office on Drugs and Crime. 2004.
  13. ↑ "Part IV, Statistical information on narcotic drugs" (PDF). International Narcotics Control Bureau, Technical Reports. 2008. Archived from the original (PDF) on 2012-03-01.
  14. ↑ "Production of thebaine and oripavine". US Patent US6376221. 2002.
  15. ↑ "Comments on the reported statistics on narcotic drugs - INCB" (PDF). Retrieved 2023-12-07.
  16. ↑ "ALTERNATIVE DEVELOPMENT - United Nations Office on Drugs and Crime" (PDF). 2001-01-12. Retrieved 2023-12-07.
  17. 1 2 "India" (PDF). United Nations Office on Drugs and Crime. September 2005. Retrieved 2009-12-16.
  18. ↑ Booth RE, Kennedy J, Brewster T, Semerik O (2003). "Drug injectors and dealers in Odesa, Ukraine". Journal of Psychoactive Drugs. 35 (4): 419–26. doi:10.1080/02791072.2003.10400488. PMID   14986870. S2CID   25325545.
  19. ↑ Dumchev KV, Soldyshev R, Qian HZ, Zezyulin OO, Chandler SD, Slobodyanyuk P, Moroz L, Schumacher JE (2009). "HIV and hepatitis C virus infections among hanka injection drug users in central Ukraine: a cross-sectional survey". Harm Reduction Journal. 6: 23. doi: 10.1186/1477-7517-6-23 . PMC   2741433 . PMID   19698166.
  20. ↑ Taracha E, Habrat B, Chmielewska K, Baran-Furga H (2005). "Excretion profile of opiates in dependent patients in relation to route of administration and type of drug measured in urine with immunoassay". Journal of Analytical Toxicology. 29 (1): 15–21. doi: 10.1093/jat/29.1.15 . PMID   15808008.
  21. ↑ Reid RG, Durham DG, Boyle SP, Low AS, Wangboonskul J (December 2007). "Differentiation of opium and poppy straw using capillary electrophoresis and pattern recognition techniques". Analytica Chimica Acta. 605 (1): 20–7. doi:10.1016/j.aca.2007.10.023. PMID   18022406.
  22. ↑ Odell LR, Skopec J, McCluskey A (March 2008). "Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin". Forensic Science International. 175 (2–3): 202–8. doi:10.1016/j.forsciint.2007.07.002. PMID   17765420.
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