Benzodioxolefentanyl

Last updated
Benzodioxolefentanyl
Benzodioxolefentanyl structure.png
Legal status
Legal status
Identifiers
  • N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]-2H-1,3-benzodioxole-5-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C27H28N2O3
Molar mass 428.532 g·mol−1
3D model (JSmol)
  • c3cc1OCOc1cc3C(=O)N(c4ccccc4)C2CCN(CC2)CCc5ccccc5
  • InChI=1S/C27H28N2O3/c30-27(22-11-12-25-26(19-22)32-20-31-25)29(23-9-5-2-6-10-23)24-14-17-28(18-15-24)16-13-21-7-3-1-4-8-21/h1-12,19,24H,13-18,20H2
  • Key:ZFAAZMIOHJNKGD-UHFFFAOYSA-N

Benzodioxolefentanyl is an opioid analgesic that is an analog of fentanyl and has been sold as a designer drug. [2] [3]

Contents

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. [4] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week. [5]

In the United States, fentanyl-related substances are Schedule I controlled substances. [1] Benzodioxolefentanyl was banned in Sweden in July 2017, [6] and in Finland in September 2017. [7]

See also

References

  1. 1 2 Drug Enforcement Administration, Department of Justice (2018). "Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order". Federal Register. 83 (25): 5188–92. PMID   29932611.
  2. ↑ European Project Response. Analytical Report Benzodioxole-F. National Forensic Laboratory, Slovenia. 14 September 2016
  3. ↑ Pierzynski HG. Tips for Interpreting GC-MS Fragmentation of Unknown Substituted Fentanyls. Cayman Chemical, 23 August 2017
  4. ↑ Mounteney J, Giraudon I, Denissov G, Griffiths P (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe" . The International Journal on Drug Policy. 26 (7): 626–31. doi:10.1016/j.drugpo.2015.04.003. PMID   25976511.
  5. ↑ Armenian P, Vo KT, Barr-Walker J, Lynch KL (October 2017). "Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review" (PDF). Neuropharmacology. 134 (Pt A): 121–132. doi:10.1016/j.neuropharm.2017.10.016. PMID   29042317. S2CID   21404877.
  6. ↑ The Public Health Agency of Sweden. Tretton nya ämnen klassas som narkotika eller hälsofarlig vara. 28 July 2017
  7. ↑ European Commission. Notification detail. Government Decree amending Annex IV to the Government Decree on substances, preparations and plants to be classified as narcotics The following 9 new substances are classified: 4-chloro-isobutyrfentanyl, 4-Fluoro-isobutyrfentanyl, 3-phenylpropanoylfentanyl, benzodioxole fentanyl, benzoyl fentanyl, cyclopentyl fentanyl, cyclopropyl fentanyl, methoxyacetyl fentanyl and tetramethylcyclopropyane fentanyl. 12 September 2017
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