Etonitazepipne

Last updated

Etonitazepipne
Etonitazepipne.svg
Legal status
Legal status
Identifiers
  • 2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-piperidin-1-ylethyl)benzimidazole
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C23H28N4O3
Molar mass 408.502 g·mol−1
3D model (JSmol)
  • CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCCC4)C=CC(=C3)[N+](=O)[O-]
  • InChI=1S/C23H28N4O3/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25/h6-11,17H,2-5,12-16H2,1H3
  • Key:UMGXRAISFRUVKD-UHFFFAOYSA-N

Etonitazepipne (N-piperidino etonitazene) is a benzimidazole derivative with opioid effects around 100 times more potent than morphine, [1] [2] which has been sold over the internet as a designer drug. [3] [4] [5] [6]

See also

References

  1. ↑ Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen". Helvetica Chimica Acta. 43 (4): 1032–1046. doi:10.1002/hlca.19600430412.
  2. ↑ Berardinelli D, Taoussi O, Carlier J, Tini A, Zaami S, Sundermann T, et al. (July 2024). "In vitro, in vivo metabolism and quantification of the novel synthetic opioid N-piperidinyl etonitazene (etonitazepipne)". Clinical Chemistry and Laboratory Medicine. 62 (8): 1580–1590. doi:10.1515/cclm-2023-1360. PMID   38311816.
  3. ↑ "Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne". National Drug Early Warning System. Weekly Briefing (43). 9 July 2021.
  4. ↑ "Warnings Etonitazepipne". Knowdrugs.app. 9 August 2021.
  5. ↑ Vandeputte MM, Verougstraete N, Walther D, Glatfelter GC, Malfliet J, Baumann MH, et al. (June 2022). "First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass". Archives of Toxicology. 96 (6): 1865–1880. Bibcode:2022ArTox..96.1865V. doi:10.1007/s00204-022-03294-2. hdl: 1854/LU-8751259 . PMID   35449307. S2CID   253718213.
  6. ↑ Calello DP, Aldy K, Jefri M, Nguyen TT, Krotulski A, Logan B, et al. (September 2022). "Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose". Clinical Toxicology. 60 (9): 1067–1069. doi:10.1080/15563650.2022.2084406. PMC   9815205 . PMID   35708103.
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