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Other names | Isolator |
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Uses | Inert atmosphere work Hazardous materials work |
Related items | Desiccator Schlenk line |
A glovebox (or glove box) is a sealed container that is designed to allow one to manipulate objects where a separate atmosphere is desired. Built into the sides of the glovebox are gloves arranged in such a way that the user can place their hands into the gloves and perform tasks inside the box without breaking containment. Part or all of the box is usually transparent to allow the user to see what is being manipulated. Two types of gloveboxes exist. The first allows a person to work with hazardous substances, such as radioactive materials or infectious disease agents, and the second allows manipulation of substances that must be contained within a very high purity inert atmosphere, such as argon or nitrogen. It is also possible to use a glovebox for manipulation of items in a vacuum chamber.
The gas in a glovebox is pumped through a series of treatment devices which remove solvents, water and oxygen from the gas. Copper metal (or some other finely divided metal) is commonly used to remove oxygen, this oxygen removing column is normally regenerated by passing a hydrogen/nitrogen mixture through it while it is heated: the water formed is passed out of the box with the excess hydrogen and nitrogen. It is common to use molecular sieves to remove water by absorbing it in the molecular sieves' pores. Such a box is often used by organometallic chemists to transfer dry solids from one container to another container.
An alternative to using a glovebox for air sensitive work is to employ Schlenk methods using a Schlenk line. One disadvantage of working in a glovebox is that organic solvents will attack the plastic seals. As a result, the box will start to leak and water and oxygen can then enter the box. Another disadvantage of a glovebox is that oxygen and water can diffuse through the plastic gloves. Also, coordinating solvents, such as tetrahydrofuran and dichloromethane, can bind irreversibly to the copper catalyst, reducing its effectiveness. One way to prolong the lifespan of the glovebox and catalyst is to turn off circulation when using solvents, followed by purging when work involving solvents is finished.
Inert atmosphere gloveboxes are typically kept at a higher pressure than the surrounding air, so that any microscopic leaks are mostly leaking inert gas out of the box instead of letting air in.
At the now-deactivated Rocky Flats Plant, which manufactured plutonium triggers, also called "pits", production facilities consisted of linked stainless steel gloveboxes up to 64 feet, or 20 meters, in length, which contained the equipment which forged and machined the trigger parts. The gloves were lead-lined. Other materials used in the gloveboxes included acrylic viewing windows and Benelex shielding composed of wood fiber and plastic which shielded against neutron radiation. Manipulation of the lead-lined gloves was onerous work.
Some gloveboxes for radioactive work are under inert conditions, for instance, one nitrogen-filled box contains an argon-filled box. The argon box is fitted with a gas treatment system to keep the gas very pure to enable electrochemical experiments in molten salts. [1]
Gloveboxes are also used in the biological sciences when dealing with anaerobes or high-biosafety level pathogens.
Gloveboxes used for hazardous materials are generally maintained at a lower pressure than the surrounding atmosphere, so that microscopic leaks result in air intake rather than hazard outflow. Gloveboxes used for hazardous materials generally incorporate HEPA filters into the exhaust, to keep the hazard contained.
Argon is a chemical element; it has symbol Ar and atomic number 18. It is in group 18 of the periodic table and is a noble gas. Argon is the third most abundant gas in Earth's atmosphere, at 0.934%. It is more than twice as abundant as water vapor, 23 times as abundant as carbon dioxide, and more than 500 times as abundant as neon. Argon is the most abundant noble gas in Earth's crust, comprising 0.00015% of the crust.
A substance is pyrophoric if it ignites spontaneously in air at or below 54 °C (129 °F) or within 5 minutes after coming into contact with air. Examples are organolithium compounds and triethylborane. Pyrophoric materials are often water-reactive as well and will ignite when they contact water or humid air. They can be handled safely in atmospheres of argon or nitrogen. Class D fire extinguishers are designated for use in fires involving pyrophoric materials. A related concept is hypergolicity, in which two compounds spontaneously ignite when mixed.
An inert gas is a gas that does not readily undergo chemical reactions with other chemical substances and therefore does not readily form chemical compounds. The noble gases often do not react with many substances and were historically referred to as the inert gases. Inert gases are used generally to avoid unwanted chemical reactions degrading a sample. These undesirable chemical reactions are often oxidation and hydrolysis reactions with the oxygen and moisture in air. The term inert gas is context-dependent because several of the noble gases can be made to react under certain conditions.
Bottled gas is a term used for substances which are gaseous at standard temperature and pressure (STP) and have been compressed and stored in carbon steel, stainless steel, aluminum, or composite containers known as gas cylinders.
A hermetic seal is any type of sealing that makes a given object airtight. The term originally applied to airtight glass containers, but as technology advanced it applied to a larger category of materials, including rubber and plastics. Hermetic seals are essential to the correct and safe functionality of many electronic and healthcare products. Used technically, it is stated in conjunction with a specific test method and conditions of use.
Shielding gases are inert or semi-inert gases that are commonly used in several welding processes, most notably gas metal arc welding and gas tungsten arc welding. Their purpose is to protect the weld area from oxygen, and water vapour. Depending on the materials being welded, these atmospheric gases can reduce the quality of the weld or make the welding more difficult. Other arc welding processes use alternative methods of protecting the weld from the atmosphere as well – shielded metal arc welding, for example, uses an electrode covered in a flux that produces carbon dioxide when consumed, a semi-inert gas that is an acceptable shielding gas for welding steel.
Degassing, also known as degasification, is the removal of dissolved gases from liquids, especially water or aqueous solutions. There are numerous methods for removing gases from liquids.
Shielded nuclear radiation containment chambers are commonly referred to as hot cells. The word "hot" refers to radioactivity. Hot cells are used in both the nuclear-energy and the nuclear-medicines industries. They are required to protect individuals from radioactive isotopes by providing a safe containment box in which they can control and manipulate the equipment required.
A packaging gas is used to pack sensitive materials such as food into a modified atmosphere environment. The gas used is usually inert, or of a nature that protects the integrity of the packaged goods, inhibiting unwanted chemical reactions such as food spoilage or oxidation. Some may also serve as a propellant for aerosol sprays like cans of whipped cream. For packaging food, the use of various gases is approved by regulatory organisations.
Inert gas asphyxiation is a form of asphyxiation which results from breathing a physiologically inert gas in the absence of oxygen, or a low amount of oxygen, rather than atmospheric air. Examples of physiologically inert gases, which have caused accidental or deliberate death by this mechanism, are argon, helium, nitrogen and methane. The term "physiologically inert" is used to indicate a gas which has no toxic or anesthetic properties and does not act upon the heart or hemoglobin. Instead, the gas acts as a simple diluent to reduce the oxygen concentration in inspired gas and blood to dangerously low levels, thereby eventually depriving all cells in the body of oxygen.
The Schlenk line is a commonly used chemistry apparatus developed by Wilhelm Schlenk. It consists of a dual manifold with several ports. One manifold is connected to a source of purified inert gas, while the other is connected to a vacuum pump. The inert-gas line is vented through an oil bubbler, while solvent vapors and gaseous reaction products are prevented from contaminating the vacuum pump by a liquid-nitrogen or dry-ice/acetone cold trap. Special stopcocks or Teflon taps allow vacuum or inert gas to be selected without the need for placing the sample on a separate line.
An asphyxiant gas, also known as a simple asphyxiant, is a nontoxic or minimally toxic gas which reduces or displaces the normal oxygen concentration in breathing air. Breathing of oxygen-depleted air can lead to death by asphyxiation (suffocation). Because asphyxiant gases are relatively inert and odorless, their presence in high concentration may not be noticed, except in the case of carbon dioxide (hypercapnia).
Air sensitivity is a term used, particularly in chemistry, to denote the reactivity of chemical compounds with some constituent of air. Most often, reactions occur with atmospheric oxygen (O2) or water vapor (H2O), although reactions with the other constituents of air such as carbon monoxide (CO), carbon dioxide (CO2), and nitrogen (N2) are also possible.
A Schlenk flask, or Schlenk tube, is a reaction vessel typically used in air-sensitive chemistry, invented by Wilhelm Schlenk. It has a side arm fitted with a PTFE or ground glass stopcock, which allows the vessel to be evacuated or filled with gases. These flasks are often connected to Schlenk lines, which allow both operations to be done easily.
A drying tube or guard tube is a tube-like piece of apparatus used to house a disposable solid desiccant, wherein at one end the tube-like structure terminates in a ground glass joint for use in connecting the drying tube to a reaction vessel, for the purpose of keeping the vessel free of moisture.
Air-free techniques refer to a range of manipulations in the chemistry laboratory for the handling of compounds that are air-sensitive. These techniques prevent the compounds from reacting with components of air, usually water and oxygen; less commonly carbon dioxide and nitrogen. A common theme among these techniques is the use of a fine (100–10−3 Torr) or high (10−3–10−6 Torr) vacuum to remove air, and the use of an inert gas: preferably argon, but often nitrogen.
In chemistry, the term chemically inert is used to describe a substance that is not chemically reactive. From a thermodynamic perspective, a substance is inert, or nonlabile, if it is thermodynamically unstable yet decomposes at a slow, or negligible rate.
A cryogenic gas plant is an industrial facility that creates molecular oxygen, molecular nitrogen, argon, krypton, helium, and xenon at relatively high purity. As air is made up of nitrogen, the most common gas in the atmosphere, at 78%, with oxygen at 19%, and argon at 1%, with trace gasses making up the rest, cryogenic gas plants separate air inside a distillation column at cryogenic temperatures to produce high purity gasses such as argon, nitrogen, oxygen, and many more with 1 ppm or less impurities. The process is based on the general theory of the Hampson-Linde cycle of air separation, which was invented by Carl von Linde in 1895.
The Microgravity Science Glovebox (MSG) is a glovebox aboard the International Space Station (ISS). It provides a safe contained environment for research with liquids, combustion and hazardous materials in the microgravity conditions of the ISS. Without the MSG, many types of hands-on investigations would be impossible or severely limited on board the Station. The Microgravity Science Glovebox (MSG) occupies a floor-to-ceiling rack inside the Destiny module of the ISS. It is more than twice as large as gloveboxes flown on the Space Shuttle and could contain larger investigations that are about twice the size of an airline carry-on bag. A follow-on sister facility, managed by the same group at Marshall Space Flight Center, is intended to further support biological experiments with the Life Sciences Glovebox.
Weld purging is the act of removing, from the vicinity of the joint; oxygen, water vapour and any other gases or vapours that might oxidize or contaminate a welding joint as it is being welded and immediately after welding.