Isotocyanozene

Last updated

Isotocyanozene
Isotocyanazene structure.png
Identifiers
  • 1-[2-(diethylamino)ethyl]-2-[(4-prop-2-yloxyphenyl)methyl]benzimidazole-5-carbonitrile
Chemical and physical data
Formula C24H30N4O
Molar mass 390.531 g·mol−1
3D model (JSmol)
  • CC(C)Oc1ccc(cc1)Cc1nc2cc(ccc2n1CCN(CC)CC)C#N
  • InChI=InChI=1S/C24H30N4O/c1-5-27(6-2)13-14-28-23-12-9-20(17-25)15-22(23)26-24(28)16-19-7-10-21(11-8-19)29-18(3)4/h7-12,15,18H,5-6,13-14,16H2,1-4H3
  • Key:PCHKHUKJPIKAGU-UHFFFAOYSA-N

Isotocyanozene (5-cyano-isotodesnitazene) is a benzimidazole opioid analogue of isotonitazene which has been sold as a designer drug. It was first prospectively observed in a toxicological sample in the Scotland, United Kingdom in 2025, and was presumed to have opioid effects. [1] It has been identified by the drug checking service CanTEST, Australia in September 2025 as an expected 'opioid' sample, and then later as an expected 'benzodiazepine' sample. [2] [3] The relative activity of this nitro to cyano substituted analogue is unknown, although the corresponding ethoxy derivative etocyanozene is known to be more potent than etodesnitazene but significantly less potent than etonitazene itself.

See also

References

  1. McHenry RD, Dunlop LC, Hudson S, Walters M, Dear JW, Lowe DJ (July 2025). "Isotocyanozene: detection of the 5-cyano analog of isotonitazene in human biological samples". Clinical Toxicology. 63 (9). Philadelphia, Pa.: 691–692. doi:10.1080/15563650.2025.2528990. PMID   40625206.
  2. CanTEST Health and drug checking service, Canberra (September 2025). "Community Notice 22nd of September 2025: Isotocyanozene found in 'opioid' capsule". Instagram, official account of CanTEST.{{cite web}}: CS1 maint: multiple names: authors list (link)
  3. "Isotocyanozene found in 'opioid' capsule - The Know". 2025-09-22. Retrieved 2025-09-23.