Thomas Kailath (2012) – presented by President Barack Obama in 2014 for "transformative contributions to the fields of information and system science, for distinctive and sustained mentoring of young scholars, and for translation of scientific ideas into entrepreneurial ventures that have had a significant impact on industry"[11][12]
Abraham Mathai Nooranal, IES, IPS, UN International Civil Service, retired as Chief Security Advisor of United Nations Human Rights, Geneva, continuing as a Europe based Senior Consultant at the UN.
Barrister George Joseph (1887–1938) – lawyer and Indian independence activist. Remembered for his role in Home Rule agitation and Vaikom Satyagraha, and for his editorship of Motilal Nehru's The Independent and Mahatma Gandhi's Young India.
Advocate V.J Mathai – lawyer and Indian independence activist, Best known for being the first Indian to defeat a European in an election.
Academia
Scientists
Tessy Thomas (1963–) – Indian scientist and Director General of Aeronautical Systems and the former Project Director for Agni-IV missile in Defence Research and Development Organisation. She is the first woman scientist to head a missile project in India. She is known as the 'Missile Woman' of India.
George Varghese – Principal Researcher at Microsoft Research
Prof Joseph Vettukattil. Inventor AFR device, VASO, VB stent. Endowed chair Congenital Cardiology Research. First certified pediatric cardiologist UK. Structured multiplanar reformating of 3D echocardiography. First to do 3D printing from echocardiography and first in the world to do multimodality image integration.
A. J. John, Anaparambil – one of the founding leaders of Travancore State Congress. Former Chief Minister of Kerala.2nd Assembly (1952–53) (1951 election)
Rosamma Punnoose – independence activist, politician and lawyer and the first person to be sworn in as a member of the Kerala Legislative Assembly.
Archdeacon K. Koshy (1825–1899) – author of Pulleli Kunju (1882); the first novellike original work on a local theme, in Malayalam, and a number of other books
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