Brodmann area 49

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Brodmann area 49
Identifiers
FMA 81152
Anatomical terminology

In the rodent, the parasubiculum is a retrohippocampal isocortical structure, and a major component of the subicular complex. It receives numerous subcortical and cortical inputs, and sends major projections to the superficial layers of the entorhinal cortex. [1]

Contents

The parasubicular area is a transitional zone between the presubiculum and the entorhinal area in the mouse (Paxinos-2001), the rat (Swanson, 1998) and the primate. [2] Defined on the basis of cytoarchitecture, it is more similar to the presubiculum than to the entorhinal area, [2] however electrophysiological evidence suggests a similarity with the entorhinal cortex. [3] [4] Specifically, cells in this area are modulated by local theta rhythm, and display theta-frequency membrane potential oscillations. [3] [5] Furthermore, cells in the parasubiculum, and neighboring presubiculum, fire in relation to the animal's location in space, suggesting properties similar to place cells. It is postulated that this area may play an integral role in spatial navigation and the integration of head-directional information. [5] [6]

See also

References

  1. ↑ Witter, M. P.; Amaral, D. G. (1995). "Hippocampal Formation". In Watson, C.; Paxinos, G. (eds.). The rat brain in stereotaxic coordinates (3 ed.).
  2. 1 2 Zilles, K.; Wree, A.; Dausch, N. D. (1990). "Anatomy of the neocortex. Neurochemical organization". The Cerebral Cortex of the Rat. Cambridge: MIT Press.
  3. 1 2 Glasgow, Stephen D.; Chapman, C. Andrew (June 2007). "Local Generation of Theta-Frequency EEG Activity in the Parasubiculum". Journal of Neurophysiology. 97 (6): 3868–3879. doi:10.1152/jn.01306.2006. ISSN   0022-3077.
  4. ↑ Funahashi, M.; Stewart, M. (1997). "Presubicular and parasubicular cortical neurons of the rat: electrophysiological and morphological properties". Hippocampus. 7 (2): 117–29.
  5. 1 2 Taube, J. S. (1995). "Place cells recorded in the parasubiculum of freely moving rats". Hippocampus. 5 (6): 569–583.
  6. ↑ Chrobak, J. J.; Buzsáki, G. (1994). "Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat". Journal of Neuroscience. 14 (10): 6160–6170.
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