Clonitazene

Clonitazene
Clinical data
Other names	Clonitazene
ATC code	none;
Legal status
Legal status	BR: Class A1 (Narcotic drugs); CA: Schedule I ; DE: Anlage I (Authorized scientific use only); UK: Class A ; US: Schedule I ;
Identifiers
	IUPAC name 2-[2-[(4-Chlorophenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine;
CAS Number	3861-76-5 ;
PubChem CID	62528 ;
DrugBank	DB01523 ;
ChemSpider	56301 ;
UNII	S90R21A2V2 ;
KEGG	D12668 ;
ChEMBL	ChEMBL2104616 ;
CompTox Dashboard (EPA)	DTXSID90191931 ;
Chemical and physical data
Formula	C20H23ClN4O2
Molar mass	386.88 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES [O-][N+](=O)c3ccc1c(nc(n1CCN(CC)CC)Cc2ccc(Cl)cc2)c3;
	InChI InChI=1S/C20H23ClN4O2/c1-3-23(4-2)11-12-24-19-10-9-17(25(26)27)14-18(19)22-20(24)13-15-5-7-16(21)8-6-15/h5-10,14H,3-4,11-13H2,1-2H3 ; Key:GPZLDQAEBHTMPG-UHFFFAOYSA-N ;
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Last updated October 09, 2025

Clonitazene is an opioid analgesic of approximately three times the potency of morphine.^[2] It is in the nitazene family of benzimidazoles related to etonitazene, an opioid of significantly higher potency. Clonitazene is not currently marketed. It is a controlled substance; in the United States it is a Schedule I Narcotic controlled substance with a DEA ACSCN of 9612 and an established manufacturing quota of 25 grams for 2022.

References

↑ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
↑ Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with basic substitutions]" [Synthesis of analgesically active benzimidazole derivatives with basic substitutions]. Experientia. 13 (10): 400–1. doi:10.1007/BF02161116. PMID 13473817. S2CID 32179439.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with basic substitutions]" [Synthesis of analgesically active benzimidazole derivatives with basic substitutions]. Experientia. 13 (10): 400–1. doi:10.1007/BF02161116. PMID 13473817. S2CID 32179439.

[1]

[2]

Clonitazene

See also

References