Ethyleneoxynitazene

Last updated

Tetrahydrofuranitazene
Tetrahydrofuranitazene structure.png
Identifiers
  • 2-(2-((2,3-dihydrobenzofuran-5-yl)methyl)-5-nitro-1H-benzo[d]imidazol-1-yl)-N,N-diethylethan-1-amine
PubChem CID
Chemical and physical data
Formula C22H26N4O3
Molar mass 394.475 g·mol−1
3D model (JSmol)
  • CCN(CC)CCN1C(CC2=CC=C(OCC3)C3=C2)=NC4=CC([N+]([O-])=O)=CC=C14
  • InChI=1S/C22H26N4O3/c1-3-24(4-2)10-11-25-20-7-6-18(26(27)28)15-19(20)23-22(25)14-16-5-8-21-17(13-16)9-12-29-21/h5-8,13,15H,3-4,9-12,14H2,1-2H3
  • Key:IPSJQZUMCSELFZ-UHFFFAOYSA-N

Ethyleneoxynitazene (Tetrahydrofuranitazene) is a benzimidazole derivative which has been sold as a designer drug over the internet and has opioid effects, though with lower potency than etonitazene itself [1] It is an analogue of etonitazene where the 4-ethoxy group attached to the benzyl ring has been cyclised round to the 3-position to form a 2,3-dihydrobenzofuran ring system. It was first reported in Estonia in February 2023, [2] subsequently in the UK in late 2023 [3] and in China July 1st. [4]

See also

References

  1. ↑ Gatch MB, Hill RD, Sundar M, Shetty RA (July 2025). "Discriminative stimulus and antinociceptive effects of sixteen nitazene analogs in rodents". Neuropharmacology. 272 110416: 110416. doi:10.1016/j.neuropharm.2025.110416. PMID   40120927.{{cite journal}}: CS1 maint: article number as page number (link)
  2. ↑ "New psychoactive substances - the current situation in Europe" (PDF). European Drug Report. European Union Drugs Agency (EUDA). 2024.
  3. ↑ "Third addendum to ACMD report on the use and harms of 2-benzyl benzimidazole ('nitazene') and piperidine benzimidazolone ('brorphine-like') opioids" (PDF). Advisory Council on the Misuse of Drugs. 15 December 2023.
  4. ↑ "Reddit - Dive into anything". www.reddit.com. Retrieved 2024-10-16.



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