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Formula | C23H28N4O3 |
Molar mass | 408.502 g·mol−1 |
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Isotonitazepyne (N-pyrrolidino-isotonitazene, NPI) is a benzimidazole derivative with potent opioid effects, which has been sold as a designer drug over the internet. It was first identified by the drug checking service CanTEST in Australia in September 2024, [1] [2] and then later in Netherlands in May 2025, [3] and in Finland in early 2025. [4] Its in vitro potency is approximately 1000 times that of morphine. [5] One sample of counterfeit oxycodone pills were found to contain between 3.3 to 3.5 mg of NPI per pill. [2]
This section is not exhaustive and does not include information for all countries with laws covering isotonitazepyne.
It is specifically listed as an illegal drug in the US state of Virginia. [6]
Since 15 January 2025 it is covered by the UK's generic definition on 2-benzyl benzimidazole derived opioids [7] [8] because it contains the backbone with only the following modifications: [9]