Kobuvirus | |
---|---|
Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Pisuviricota |
Class: | Pisoniviricetes |
Order: | Picornavirales |
Family: | Picornaviridae |
Genus: | Kobuvirus |
Kobuvirus is a genus of viruses in the order Picornavirales , in the family Picornaviridae . Humans and cattle serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: gastroenteritis. [1] [2] The genus was named because of the virus particles' lumpy appearance by electron microscopy; "kobu" means "knob" in Japanese. [3]
Three species of the genus include Aichivirus A (formerly Aichi virus), Aichivirus B (formerly Bovine kobuvirus) and Aichivirus C (formerly Porcine kobuvirus) each possessing a single serotype. Canine kobuvirus belong to species Aichivirus A. [4] Aichi virus infects humans, [5] [6] while bovine kobuvirus, [7] porcine kobuvirus [8] [9] and canine kobuvirus, as suggested by their names, infects cattle, swine, dogs and cats.
In 2014 a novel caprine kobuvirus was characterised after isolation from a Korean black goat. [10]
Nucleic acid sequence analysis and RT-PCR are used prevalently as detection and genotyping methods of kobuvirus although, there are some other techniques such as EM, and ELISA. [11]
The genus contains the following species: [2]
Viruses in Kobuvirus are non-enveloped, with icosahedral and spherical geometries, and T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 8.25kb in length. [1] The molecular mass of a typical virion particle of this genus is typically eight to nine million. The virions of the viruses in this genus consist of capsids that are 27 to 30 nm in diameter. [5] The capsid is believed to consist of 12 capsomers and the capsid shell structure of these virions has a monolayer composition. [5] Using conventional electron microscopy, the structure of the capsid surface can be visualized. [5] [6] The virus particles contain a single species of ssRNA. These virions have a sedimentation coefficient of 140–165 S20w. The particles are described to be “relatively stable” in vitro (in comparison to other viruses) and stable in acidic conditions of pH 3.5. [6] They have also been found to be insensitive to treatment with some chemicals including chloroform, ether and non-ionic detergents. [6]
Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
---|---|---|---|---|---|
Kobuvirus | Icosahedral | Pseudo T=3 | Non-enveloped | Linear | Monopartite |
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. The virus exits the host cell by lysis, and viroporins. Human and cattle serve as the natural host. Transmission routes are fecal–oral. [1]
Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
---|---|---|---|---|---|---|---|
Kobuvirus | Humans | None | Cell receptor endocytosis | Lysis | Cytoplasm | Cytoplasm | Oral–fecal; blood |
The viruses in this genus have single-stranded, linear non-segmented, positive-sense RNA genomes with lengths of approximately 8.2–8.3 kb. [6] [7]
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Picornaviruses are a group of related nonenveloped RNA viruses which infect vertebrates including fish, mammals, and birds. They are viruses that represent a large family of small, positive-sense, single-stranded RNA viruses with a 30 nm icosahedral capsid. The viruses in this family can cause a range of diseases including the common cold, poliomyelitis, meningitis, hepatitis, and paralysis.
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Pseudoviridae is a family of viruses, which includes three genera.
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Erbovirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Horses serve as natural hosts. There is only one species in this genus: Erbovirus A. Diseases associated with this genus include: upper respiratory tract disease with viremia and fecal shedding. Viruses belonging to the genus Erbovirus have been isolated in horses with acute upper febrile respiratory disease. The structure of the Erbovirus virion is icosahedral, having a diameter of 27–30 nm.
Parechovirus is a genus of viruses in the family Picornaviridae. Humans, ferrets, and various rodents serve as natural hosts. The genus currently consists of six accepted species. Human parechoviruses may cause gastrointestinal or respiratory illness in infants, and they have been implicated in cases of myocarditis and encephalitis.
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Double-stranded RNA viruses are a polyphyletic group of viruses that have double-stranded genomes made of ribonucleic acid. The double-stranded genome is used to transcribe a positive-strand RNA by the viral RNA-dependent RNA polymerase (RdRp). The positive-strand RNA may be used as messenger RNA (mRNA) which can be translated into viral proteins by the host cell's ribosomes. The positive-strand RNA can also be replicated by the RdRp to create a new double-stranded viral genome.
Torovirus is a genus of enveloped, positive-strand RNA viruses in the order Nidovirales and family Tobaniviridae. They primarily infect vertebrates, especially cattle, pigs, and horses. Diseases associated with this genus include gastroenteritis, which commonly presents in mammals. Torovirus is the only genus in the monotypic subfamily Torovirinae. Torovirus is also a monotypic taxon, containing only one subgenus, Renitovirus.
A viral disease occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells.
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Vesivirus is a genus of viruses, in the family Caliciviridae. Swine, sea mammals, and felines serve as natural hosts. There are two species in this genus. Diseases associated with this genus include: respiratory disease, Feline calicivirus (FCV); conjunctivitis, and respiratory disease.
Aichivirus A formerly Aichi virus (AiV) is a small, round, cytopathic positive sense and ssRNA virus. It belongs to the genus Kobuvirus in the family Picornaviridae. Aichivirus A was originally identified after a 1989 outbreak of acute gastroenteritis in the Aichi Prefecture, and was likely linked to raw oyster per genetic analysis.
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