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Methamphetamine in the United States is regulated under Schedule II of the Controlled Substances Act. It is approved for pharmacological use in the treatment of attention deficit hyperactivity disorder, narcolepsy, and treatment-resistant obesity, but it is primarily used as a recreational drug. In 2012, 16,000 prescriptions for methamphetamine were filled, approximately 1.2 million Americans reported using it in the past year, and 440,000 reported using the drug in the past month. [2]
Until the 1980s, the methamphetamine market in the United States was dominated by outlaw motorcycle gangs, namely the Hells Angels. [3] [4] [5] [6] [7] Before the late 2000s, much of the methamphetamine consumed in the US was manufactured domestically by amateur chemists in meth labs. They manufactured it from common household drugs and chemicals such as lye, lithium, and ammonia.
But after the Combat Methamphetamine Epidemic Act of 2005 went into effect in 2006, the Drug Enforcement Administration reported a sharp decline in domestic methamphetamine production and consumption. [8] As a result, the amount of methamphetamine seized, the amount of domestic drug labs shut down, and the number of associated deaths and emergency room visits also declined. [9]
However, since then, drug cartels have become the dominant producer of methamphetamine consumed in the US. They manufacture the product in clandestine facilities in Mexico and smuggle it across the border into the country. Deaths linked to methamphetamine overdoses quadrupled between 2011 and 2017. [10] [11] As of 2020 [update] , there are nine cartels involved in this process, with the Sinaloa Cartel being the dominant and the Jalisco New Generation Cartel coming in second. [12]
In 2020, the U.S. state of Oregon decriminalized small amounts of methamphetamine. [13]
During the early 1960s, amphetamine was sold in the U.S. as an over-the-counter medicine in the form of an inhaler, until the U.S. Food and Drug Administration restricted its sale to physician prescriptions. In announcing the new rules, FDA Commissioner George P. Larrick told reporters that the FDA had received 153 reports of meth use in 1964, almost three times the 54 cases from 1963, and only five a year in 1960, 1961 and 1962. [14]
In 1970, methamphetamine was regulated in the Controlled Substances Act, and a public education campaign was mounted against it. [15]
In the 1980s, drug treatment counselors saw increased use of the drug among men who have sex with men. Mexican drug manufacturers began bringing methamphetamine north of the border, and forms of methamphetamine that could be smoked were introduced. [15]
In 1983, laws were passed in the United States prohibiting possession of precursors and equipment for methamphetamine production. In 1986, the U.S. government passed the Federal Controlled Substance Analogue Enforcement Act in an attempt to curb the growing use of designer drugs. Despite this, use of methamphetamine expanded from its initial base in California throughout the rural United States, especially through the Midwest and South. [16] "Government officials in a majority of U.S. counties now report that meth is their counties’ most serious drug problem. Meth use is said to be particularly rampant in the American western states, where the substance is in high demand. States like Montana, South Dakota, Idaho, Colorado and Arizona have all launched extensive efforts – both private and public – to fight the meth menace." [17]
Since 1989, five U.S. federal laws and dozens of state laws have been imposed in an attempt to curb the production of methamphetamine. Methamphetamine can be produced in home laboratories using pseudoephedrine or ephedrine, which, at the time, were the active ingredients in over-the-counter drugs such as Sudafed and Contac. Preventive legal strategies of the past 17 years have steadily increased restrictions to the distribution of pseudoephedrine/ephedrine-containing products. [18] As a result "pharmaceutical companies and retailers such as Target, Walgreens, CVS, Kroger and Winn-Dixie have restricted sales of pseudoephedrine-containing products. Purchasers have been limited to buying small quantities and required to show I.D. to purchase them." [17]
In the 1990s, new ways to synthesize methamphetamine appeared. Some new versions were reported to be four to six times stronger. Greatest use was seen in the Southwest and West United States, but methamphetamine use began and grew in the rural Midwest. Rural locations become ideal for cooking of methamphetamine because of geographic isolation and an available supply of ephedrine, pseudoephedrine and anhydrous ammonia. [15]
Attorney General Janet Reno was very outspoken in warning mayors, police chiefs and the Judicial and Executive branches of the Federal government and as a Florida States' Attorney about the dangers of meth (-amphetamines) as early as 1996 and before. She was reported by the Orlando Sentinel as commenting that illegal trafficking in methamphetamine, a dangerous and powerful stimulant, had been spreading rapidly across the United States. [19] She appeared at the 68th session of the United States Conference of Mayors Winter Meeting in Washington, D.C., in 2000 with President Clinton and others to discuss social and law enforcement dangers of the drug nationally, especially in medium-sized and rural communities in order to deal with "the rapidly emerging issue of meth in America, discuss the unique needs of smaller and mid-sized communities to deal with the crisis, and develop prevention, treatment and interdiction strategies for meth which can then be applied to cities of all sizes as the methamphetamine crisis spreads across the nation." [20]
As a result of the U.S. Combat Methamphetamine Epidemic Act of 2005 (CMEA), which was passed as an amendment to the renewal of the USA PATRIOT Act, [17] there are restrictions on the amount of pseudoephedrine and ephedrine one may purchase in a specified time period and further requirements that these products must be stored in order to prevent theft. [18] "The CMEA requires record-keeping and identification of all sales and reports to law enforcement of any "suspicious" transactions. Purchasers are limited to "3.6 grams of pseudoephedrine base" per day and 9 grams per month. (Buying more than that is a federal misdemeanor.)" [17] Increasingly strict restrictions have resulted in the reformulation of many over-the-counter drugs, and some, such as Actifed, have been discontinued entirely in the United States.
In 1996, Congress passed the Comprehensive Methamphetamine Control Act, which regulates mail order and chemical companies selling precursor chemicals. For example, people purchasing large quantities of red phosphorus, iodine and hydrochloric gas were required to document that they intended them for legitimate purposes. Law enforcement agents were allowed to track large mail order purchases of pseudoephedrine, another precursor chemical. Chemical supply companies could be prosecuted for selling chemicals to people who make methamphetamine. [15]
By 2000, in the Inland Northwest, and in much of the West United States, methamphetamine was the favored hard drug, surpassing crack and cocaine as the stimulant of choice, as it offered 3.5 times more potency, and a much longer half life. Heroin use was also being surpassed with methamphetamine, which unlike heroin, is not severely cut and reduced in potency with other additive substances. The crystalline form of methamphetamine contained at least 80 percent purity. [15] [21]
The Illinois Methamphetamine Precursor Control Act was passed into state law in 2005 and came into effect in 2006.
Methamphetamine is FDA approved for the treatment of ADHD and exogenous obesity. It is dispensed in the USA under the trademark name "Desoxyn" [22] and manufactured by Ovation Pharmaceuticals. [23]
The levorotary form of methamphetamine, called levomethamphetamine, is an over-the-counter drug used in nasal decongestants inhalers. [24]
In 2020, voters in Oregon approved a law decriminalizing possession of small amounts of methamphetamine, making Oregon the first U.S. state to decriminalize methamphetamine. [25] [26]
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The Drug Enforcement Administration (DEA) is tasked with combating illegal meth production, distribution and use. The seized quantities of meth can give an idea about its changing popularity through the time.
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Meth lab waste is toxic and extremely hazardous, making cleanup a major problem for authorities and property owners. Common wastes include discarded chemical containers (acid, drain cleaner, iodine, rubbing alcohol, starter fluid, toluene, etc.), chemical-stained cloth and coffee filters, glassware and baking dishes, hoses, lithium batteries, propane tanks, and pseudoephedrine blister packs. [29] [30] According to the US Department of Justice, a meth lab "produces 5 to 7 pounds of toxic waste for every pound of methamphetamine produced. Operators often dispose of this waste improperly, simply by dumping it near the laboratory. This can cause contamination of the soil and nearby water supplies." [29]
Operators of meth labs have been prosecuted for environmental crimes.
Doses of 200 mg or more of methamphetamine are considered lethal. [31] Symptoms of methamphetamine toxicity include difficulty breathing, agitation, heart attack, high body temperature, seizures, stroke, and in extreme cases, coma. [32] There are no standalone drugs to reverse methamphetamine toxicity but benzodiazepines are generally used to manage the physical symptoms of toxicity, while antipsychotic drugs such as olanzapine and haloperidol are used to manage the psychological effects. [33] Harm reduction strategies for preventing meth overdoses include not injecting it and avoiding mixing it with other illicit drugs or prescription medications such as SSRIs, SNRIs and SNDRIs. [34] [35]
The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 and signed into law by President Richard Nixon. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs.
Pseudoephedrine, sold under the brand name Sudafed among others, is a sympathomimetic medication which is used as a decongestant to treat nasal congestion. It has also been used off-label for certain other indications, like treatment of low blood pressure. At higher doses, it may produce various additional effects, including psychostimulant, appetite suppressant, and performance-enhancing effects. In relation to this, non-medical use of pseudoephedrine has been encountered. The medication is taken by mouth.
Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in nasal congestion. It can be taken by mouth or by injection into a muscle, vein, or just under the skin. Onset with intravenous use is fast, while injection into a muscle can take 20 minutes, and by mouth can take an hour for effect. When given by injection it lasts about an hour and when taken by mouth it can last up to four hours.
The illegal drug trade, drug trafficking, or narcotrafficking is a global black market dedicated to the cultivation, manufacture, distribution and sale of prohibited drugs. Most jurisdictions prohibit trade, except under license, of many types of drugs through the use of drug prohibition laws. The think tank Global Financial Integrity's Transnational Crime and the Developing World report estimates the size of the global illicit drug market between US$426 and US$652 billion in 2014 alone. With a world GDP of US$78 trillion in the same year, the illegal drug trade may be estimated as nearly 1% of total global trade. Consumption of illegal drugs is widespread globally, and it remains very difficult for local authorities to reduce the rates of drug consumption.
Methcathinone is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration. It is usually snorted, but can be smoked, injected, or taken orally.
D-norpseudoephedrine, also known as cathine and (+)-norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which acts as a stimulant. Along with cathinone, it is found naturally in Catha edulis (khat), and contributes to its overall effects. It has approximately 7-10% the potency of amphetamine.
Clandestine chemistry is chemistry carried out in secret, and particularly in illegal drug laboratories. Larger labs are usually run by gangs or organized crime intending to produce for distribution on the black market. Smaller labs can be run by individual chemists working clandestinely in order to synthesize smaller amounts of controlled substances or simply out of a hobbyist interest in chemistry, often because of the difficulty in ascertaining the purity of other, illegally synthesized drugs obtained on the black market. The term clandestine lab is generally used in any situation involving the production of illicit compounds, regardless of whether the facilities being used qualify as a true laboratory.
Levmetamfetamine, also known as l-desoxyephedrine or levomethamphetamine, and commonly sold under the brand name Vicks VapoInhaler among others, is an optical isomer of methamphetamine primarily used as a topical nasal decongestant. It is used to treat nasal congestion from allergies and the common cold. It was first used medically as decongestant beginning in 1958 and has been used for such purposes, primarily in the United States, since then.
The Combat Methamphetamine Epidemic Act of 2005 (CMEA) is federal legislation enacted in the United States on March 9, 2006, to regulate, among other things, retail over-the-counter sales of following products because of their use in the manufacture of illegal drugs:
Methamphetamine is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth, is widely used. Methamphetamine is rarely prescribed over concerns involving its potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.
The drug policy in the United States is the activity of the federal government relating to the regulation of drugs. Starting in the early 1900s, the United States government began enforcing drug policies. These policies criminalized drugs such as opium, morphine, heroin, and cocaine outside of medical use. The drug policies put into place are enforced by the Food and Drug Administration and the Drug Enforcement Administration. Classification of Drugs are defined and enforced using the Controlled Substance Act, which lists different drugs into their respective substances based on its potential of abuse and potential for medical use. Four different categories of drugs are Alcohol, Cannabis, Opioids, and Stimulants.
The illegal drug trade in China is influenced by factors such as history, location, size, population, and current economic conditions. China has one-sixth of the world's population and a large and expanding economy. China's large land mass, close proximity to the Golden Triangle, Golden Crescent, and numerous coastal cities with large and modern port facilities make it an attractive transit center for drug traffickers. Opium has played an important role in the country's history since before the First and Second Opium Wars in the mid-19th century.
The Colima Cartel was a Mexican drug trafficking and methamphetamine producing cartel operating in Guadalajara, Jalisco. It was founded and led by José de Jesús Amezcua Contreras and supported by his brothers Adán and Luis.
The Sinaloa Cartel, also known as the Guzmán-Zambada Organization, the Federation, the Blood Alliance, or the Pacific Cartel, is a large, international organized crime syndicate based in the city of Culiacán, Sinaloa, Mexico that specializes in illegal drug trafficking and money laundering.
The U.S. state of Oregon has various policies restricting the production, sale, and use of different substances. In 2006, Oregon's per capita drug use exceeded the national average. The most used substances were marijuana, methamphetamine and illicit painkillers and stimulants.
The production, distribution, and sale of methamphetamine is restricted or illegal in many jurisdictions.
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.
The US federal government is an opponent of the illegal drug trade; however, state laws vary greatly and in some cases contradict federal laws.
Amphetamine and methamphetamine are central nervous system stimulants used to treat a variety of conditions. When used recreationally, they are colloquially known as "speed" or sometimes "crank". Amphetamine was first synthesized in 1887 in Germany by Romanian chemist Lazăr Edeleanu, who named it phenylisopropylamine. Around the same time, Japanese organic chemist Nagai Nagayoshi isolated ephedrine from the Chinese ephedra plant and later developed a method for ephedrine synthesis. Methamphetamine was synthesized from ephedrine in 1893 by Nagayoshi. Neither drug had a pharmacological use until 1934, when Smith, Kline & French began selling amphetamine as an inhaler under the trade name Benzedrine for congestion.
Amphetamine type stimulants (ATS) are a group of synthetic drugs that are chemical derivatives of the parent compound alpha-methylphenethylamine, also known as amphetamine. Common ATS includes amphetamine, methamphetamine, ephedrine, pseudoephedrine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxyethylamphetamine (MDEA). ATS when used illicitly has street names including ice, meth, crystal, crank, bennies, and speed. Within the group of amphetamine-type stimulants, there are also prescription drugs including mixed amphetamine salts, dextroamphetamine, and lisdexamfetamine.
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: CS1 maint: location (link)The Sinaloa Cartel maintains the widest national influence, with its most dominant positions along the West Coast, in the Midwest, and in the Northeast. The CJNG continues to be the Mexican TCO with second-most widespread domestic influence