Date | 9 January 2015 |
---|---|
Venue | Funeral |
Location | Tete Province, Mozambique |
Coordinates | 15°44′13″S32°46′19″E / 15.737°S 32.772°E [1] |
Cause | Contaminated beer, Burkholderia gladioli , bongkrekic acid, toxoflavin. |
First reporter | Radio Mozambique |
Deaths | 75 |
Non-fatal injuries | More than 230 [2] |
On 9 January 2015, 75 people died and 230 were made ill after drinking contaminated beer at a funeral in Mozambique. All of the people affected had consumed the local beer, pombe , on 9 January, which had been inadvertently contaminated by the bacterium Burkholderia gladioli which produced the toxic compound bongkrekic acid. [2]
Early speculation on the source of the illness by Mozambique officials blamed crocodile bile. A Forbes article opposed this hypothesis and instead pointed to the toxic flowering plant foxglove as the likely source of the poison. [3] [4] Only in November 2015 was it determined that the deaths and illnesses were a result of bacterial contamination of the beer. [5]
Radio Mozambique reported that 69 people had died from the villages of Chitima and Songo, both in Tete Province. Following a funeral, 196 were hospitalized on 9 January in the western part of the country. Those affected had consumed homemade pombe beer, a traditional fermented beverage made of sorghum, bran, corn, and sugar with Schizosaccharomyces pombe yeast, a different yeast than those used in Western-style brewing. [6]
The first reported dead on the following day included the drink stand owner, two of her relatives, and four neighbors. Paula Bernardo, director of Health, Women, and Social Action in the Cahora Bassa region, said that area hospitals were flooded with people suffering from cramps and diarrhea and that more people had died. [6] As of 12 January, 169 people remained hospitalized, but that number dropped to 35 on 13 January. [7] President Armando Guebuza announced three days of national mourning. [8]
Early reports suggested the beer had been poisoned with "crocodile bile", known and sold by local practitioners as "nduru". [9] [10] An alternative early theory, presented in Forbes magazine online, suggested the active ingredient in such poisonings was perhaps a cardiac glycoside, such as digitalis. Digitalis purpurea , the variety of foxglove flower which is the normal source of digitalis, has become common in the area after introduction by European settlers; the foxglove species that is native to Africa, Ceratotheca triloba , resembles the poisonous plant but does not contain digitalis. [6]
In the Forbes article, David Kroll surmises that while crocodile bile is reputed by local villagers to be highly toxic, this is almost certainly false. Crocodile bile resembles mammalian bile which is universally found in the digestive tract of all higher animals. Mice experimentally fed extracts of the bile did not die, and local crocodile farms dried and sold the bile for export to the Far East for use in traditional Chinese medicine. [6] Kroll cites Norman Z. Nyazema, a researcher into traditional practices and culture of Africa, who suggested that organophosphate pesticides may instead be to blame, though the cause of the deaths would remain a mystery until forensic testing was complete. [11]
Samples of the beer, blood, and suspicious objects found within the drum were sent for analysis to the National Laboratory in Maputo. [8] The investigation into the cause of the poisoning eventually turned up the presence of the bacterium Burkholderia gladioli and two toxins which it produced, bongkrekic acid and toxoflavin, in both the beer and the corn flour that was used to help brew it, and concluded that these were responsible for the deaths and illnesses. The investigative team determined that flood-damaged corn flour that had begun to rot had been offered to the brewer in the mistaken belief that, while unfit for use as food, it was still suitable for use in brewing. [5]
Beer is an alcoholic beverage produced by the brewing and fermentation of starches from cereal grain—most commonly malted barley, although wheat, maize (corn), rice, and oats are also used. The grain is mashed to convert starch in the grain to sugars, which dissolve in water to form wort. Fermentation of the wort by yeast produces ethanol and carbonation in the beer. Beer is one of the oldest alcoholic drinks in the world, the most widely consumed, and the third most popular drink after water and tea. Most modern beer is brewed with hops, which add bitterness and other flavours and act as a natural preservative and stabilising agent. Other flavouring agents, such as gruit, herbs, or fruits, may be included or used instead of hops. In commercial brewing, natural carbonation is often replaced with forced carbonation.
Digitalis is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves.
Hops are the flowers of the hop plant Humulus lupulus, a member of the Cannabaceae family of flowering plants. They are used primarily as a bittering, flavouring, and stability agent in beer, to which, in addition to bitterness, they impart floral, fruity, or citrus flavours and aromas. Hops are also used for various purposes in other beverages and herbal medicine. The hops plants have separate female and male plants, and only female plants are used for commercial production. The hop plant is a vigorous climbing herbaceous perennial, usually trained to grow up strings in a field called a hopfield, hop garden, or hop yard when grown commercially. Many different varieties of hops are grown by farmers around the world, with different types used for particular styles of beer.
Kombucha is a fermented, lightly effervescent, sweetened black tea drink. Sometimes the beverage is called kombucha tea to distinguish it from the culture of bacteria and yeast. Juice, spices, fruit or other flavorings are often added.
Foodborne illness is any illness resulting from the contamination of food by pathogenic bacteria, viruses, or parasites, as well as prions, and toxins such as aflatoxins in peanuts, poisonous mushrooms, and various species of beans that have not been boiled for at least 10 minutes.
Pruno, also known as prison hooch or prison wine, is a term used in the United States to describe an improvised alcoholic beverage. It is variously made from apples, oranges, fruit cocktail, fruit juices, hard candy, sugar, high fructose syrup, and possibly other ingredients, including crumbled bread. Bread is incorrectly thought to contain yeast for the pruno to ferment. Pruno originated in US prisons, where it can be produced with the limited selection of equipment and ingredients available to inmates. It can be made using only a plastic bag, hot running water, and a towel or sock to conceal the pulp during fermentation. The end result has been described as a "bile-flavored wine cooler". Depending on the time spent fermenting, the sugar content, and the quality of the ingredients and preparation, pruno's alcohol content by volume can range from as low as 2% to as high as 14%.
Digitalis purpurea, the foxglove or common foxglove, is a toxic species of flowering plant in the plantain family Plantaginaceae, native to and widespread throughout most of temperate Europe. It has also naturalized in parts of North America, as well as some other temperate regions. The plant is a popular garden subject, with many cultivars available. It is the original source of the heart medicine digoxin. This biennial plant grows as a rosette of leaves in the first year after sowing, before flowering and then dying in the second year. It generally produces enough seeds so that new plants will continue to grow in a garden setting.
Chhaang or chhyang is a Nepalese and Tibetan alcoholic beverage popular in parts of the eastern Himalayas among the Yakkha, Limbu, Dura, Newar, Sunuwar, Rai, Bhutia, Gurung, Magar, Sherpa, Tamang, Tharus and Lepcha communities. Among the Lepcha, it is called Chi. It is also known as jaarh in Nepal.
Beer in Africa, especially lager, is produced commercially in most African countries, and indigenous people also make varieties of beer. Beer is served in various locales, from neighbourhood shebeens to upscale bars. Many countries have standardized beer bottle sizes, which are cleaned and re-used, so when buying beer at a store, people often must pay a deposit on the bottle and the price of the beer. An alternative to glass-bottle beers is local beer sold in tetra-pak style paper cartons.
Bongkrek acid is a respiratory toxin produced in fermented coconut or corn contaminated by the bacterium Burkholderia gladioli pathovar cocovenenans. It is a highly toxic, heat-stable, colorless, odorless, and highly unsaturated tricarboxylic acid that inhibits the ADP/ATP translocase, also called the mitochondrial ADP/ATP carrier, preventing ATP from leaving the mitochondria to provide metabolic energy to the rest of the cell. Bongkrek acid, when consumed through contaminated foods, mainly targets the liver, brain, and kidneys along with symptoms that include vomiting, diarrhea, urinary retention, abdominal pain, and excessive sweating. Most of the outbreaks are found in Indonesia and China where fermented coconut and corn-based foods are consumed.
Burkholderia gladioli is a species of aerobic gram-negative rod-shaped bacteria that causes disease in both humans and plants. It can also live in symbiosis with plants and fungi and is found in soil, water, the rhizosphere, and in the microbiome of many animals. It was formerly known as Pseudomonas marginata.
Millet beer, also known as Bantu beer, malwa, pombe "Tchouk" or opaque beer, is an alcoholic beverage made from malted millet that is common throughout Africa. Its production process varies across regions and in the southern parts of Africa is more commonly known as umqombothi. Millet beer varies in taste and alcoholic content between ethnic groups. It is served in calabash gourds.
Changaa or Chang'aa is a traditional home-brewed spirit, popular in Kenya. It is made by fermentation and distillation from grains like millet, maize and sorghum, and is very potent.
Digoxin toxicity, also known as digoxin poisoning, is a type of poisoning that occurs in people who take too much of the medication digoxin or eat plants such as foxglove that contain a similar substance. Symptoms are typically vague. They may include vomiting, loss of appetite, confusion, blurred vision, changes in color perception, and decreased energy. Potential complications include an irregular heartbeat, which can be either too fast or too slow.
Methanol toxicity is poisoning from methanol, characteristically via ingestion. Symptoms may include an altered/decreased level of consciousness, poor or no coordination, vomiting, abdominal pain, and a specific smell on the breath. Decreased vision may start as early as twelve hours after exposure. Long-term outcomes may include blindness and kidney failure. Blindness may occur after drinking as little as 10 mL; death may occur after drinking quantities over 15 mL.
The following lists events that happened during 2015 in the Republic of Mozambique.
Erythrophleine is a complex alkaloid and ester of tricyclic diterpene acids derived from many of the plants in the genus erythrophleum. A highly toxic compound, it is most commonly known for its use in West African trials by ordeal. Exposure to erythrophleine can quickly lead to ataxia, dyspnea, heart paralysis, and sudden death. Visible effects of erythrophleine poisoning include induced terror, labored and irregular breathing, convulsions, urination, and vomiting.
In 1900, more than 6,000 people in England were poisoned by arsenic-tainted beer, with more than 70 of the affected dying as a result. The food safety crisis was caused by arsenic entering the supply chain through impure sugar which had been made with contaminated sulphuric acid. The illness was prevalent across the Midlands and North West England, with Manchester being the most heavily affected.