N-Desethylprotonitazene

Last updated

N-Desethylprotonitazene
N-Desethylprotonitazene structure.png
Clinical data
Routes of
administration 		Oral, intransal, vaporized
Legal status
Legal status
  • DE: Anlage II (Authorized trade only, not prescriptible)
Identifiers
  • N-Ethyl-2-(5-nitro-2-(4-propoxybenzyl)-1H-benzo[d]imidazol-1-yl)ethan-1-amine
PubChem CID
Chemical and physical data
Formula C21H26N4O3
Molar mass 382.464 g·mol−1
3D model (JSmol)
  • CCCOC1=CC=C(CC2=NC3=CC([N+]([O-])=O)=CC=C3N2CCNCC)C=C1
  • InChI=1S/C21H26N4O3/c1-3-13-28-18-8-5-16(6-9-18)14-21-23-19-15-17(25(26)27)7-10-20(19)24(21)12-11-22-4-2/h5-10,15,22H,3-4,11-14H2,1-2H3
  • Key:NPHUSRHIDKYNDO-UHFFFAOYSA-N

N-Desethylprotonitazene is a benzimidazole opioid with potent analgesic effects which has been sold as a designer drug. It was first identified in 2024 as an active metabolite of the closely related compound protonitazene, [1] [2] and was found to have less potency than it while still being more potent than fentanyl. [3] [4]

It was discovered in a drug sample from Chicago in June 2025. [3]

See also

References

  1. ↑ Ameline A, Gheddar L, Pichini S, Stove C, Aknouche F, Maruejouls C, et al. (Jul 2024). "In vitro characterization of protonitazene metabolites, using human liver microsomes, and first application to two urines collected from death cases". Clinica Chimica Acta; International Journal of Clinical Chemistry. 561 119764. Elsevier BV: 119764. doi:10.1016/j.cca.2024.119764. ISSN   0009-8981. PMID   38844019.
  2. ↑ De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, et al. (June 14, 2024). "In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids" (PDF). Archives of Toxicology. 98 (9). Springer Science and Business Media LLC: 2999–3018. Bibcode:2024ArTox..98.2999D. doi: 10.1007/s00204-024-03774-7 . ISSN   0340-5761. PMC   11324687 . PMID   38877156 . Retrieved July 19, 2025.
  3. 1 2 "Monographs". The Center for Forensic Science Research & Education. June 16, 2025. Retrieved July 19, 2025.
  4. ↑ "Substance Details N-desethyl protonitazene". United Nations : Office on Drugs and Crime. Retrieved July 19, 2025.
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