Primate experiments at Columbia University came to public attention in October 2003, when CNN reported that a university veterinarian had approached its Institutional Animal Care and Use Committee about experiments being carried out there on baboons. [1]
The veterinarian complained about experiments being conducted by an assistant professor of neurology and neurosurgery, E. Sander Connolly, who was causing strokes in baboons by carefully removing their left eyeballs and using the empty eye sockets to reach a critical blood vessel to their brains, known as the internal carotid artery. A clamp temporarily was placed on this blood vessel until the stroke was induced, after which Connolly would test a potential neuroprotective drug. [2] Connolly developed this methodology to make more consistent stroke infarcts in primates, which would improve the detection of differences in stroke treatment groups, and "provide important information not obtainable in rodent models.". [2] Of note, a more extensive version of this operation, known as an orbitozygomatic osteotomy, is also performed in humans for treatment of certain brain tumors and vascular malformations. It does not result in blindness or permanent removal of the eye. It is done because it is deemed safer way to access the bottom portions of the brain rather than going through the brain.
In a letter to the National Institutes of Health, PETA described one experiment: "On September 19, 2001, baboon B777's left eye was removed, and a stroke was induced. The next morning, it was noted that the animal could not sit up, that he was leaning over, and that he could not eat. That evening, the baboon was still slouched over and was offered food but couldn't chew. On September 21, 2001, the record shows that the baboon was 'awake, but no movement, can't eat (chew), vomited in the a.m.' With no further notation about consulting with a veterinarian, the record reads, 'At 1:30 p.m. the animal died in the cage.'" [ citation needed ]
In a letter to PETA, neurologist Robert S. Hoffman stated that he regards such experiments to be a "blind alley," and that the baboons are "kept alive for either three or ten days after experiencing a major stroke and in a condition of profound disability. This is obviously as terrifying for animals as it is for humans unless one believes that animals are incapable of terror or other emotional distress". [3] According to the published stroke model by Connolly, animals are given a stroke and maintained on anesthesia and analgesia for 12–18 hours. Then, when anesthesia is removed, animals that are not self-caring are euthanized. All other animals may be kept alive for three days, in accordance with established ethical guidelines. Then, if animals are not self-caring, they are euthanized. Animals that are self-caring at 72 hours may be kept alive for up to 10 days. [2]
A USDA investigation of the Columbia baboons found "no indication that the experiments...violated federal guidelines." Further, the Dean of Research at Columbia's School of Medicine noted that Connolly stopped the experiments because of threats from animal rights activists, despite the fact that Connolly "remained convinced that his experiments were humane and potentially valuable." [1]
People for the Ethical Treatment of Animals is an American animal rights nonprofit organization based in Norfolk, Virginia, and led by Ingrid Newkirk, its international president. PETA says that its entities have more than 9 million members globally.
Primatology is the scientific study of primates. It is a diverse discipline at the boundary between mammalogy and anthropology, and researchers can be found in academic departments of anatomy, anthropology, biology, medicine, psychology, veterinary sciences and zoology, as well as in animal sanctuaries, biomedical research facilities, museums and zoos. Primatologists study both living and extinct primates in their natural habitats and in laboratories by conducting field studies and experiments in order to understand aspects of their evolution and behavior.
Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry. The focus of animal testing varies on a continuum from pure research, focusing on developing fundamental knowledge of an organism, to applied research, which may focus on answering some questions of great practical importance, such as finding a cure for a disease. Examples of applied research include testing disease treatments, breeding, defense research, and toxicology, including cosmetics testing. In education, animal testing is sometimes a component of biology or psychology courses. The practice is regulated to varying degrees in different countries.
Ingrid Elizabeth Newkirk is a British-American animal activist and the president of People for the Ethical Treatment of Animals (PETA), the world's largest animal rights organization. She is the author of several books, including The PETA Practical Guide to Animal Rights: Simple Acts of Kindness to Help Animals in Trouble (2009) and Animalkind: Remarkable Discoveries About Animals and Revolutionary New Ways to Show Them Compassion (2020). Newkirk has worked for the animal-protection movement since 1972.
Alexander Fernando Pacheco is an American animal rights activist. He is the founder of 600 Million Dogs, co-founder and former chairman of People for the Ethical Treatment of Animals (PETA) and a member of the advisory board of the Sea Shepherd Conservation Society.
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. There are three main types of animal models: Homologous, Isomorphic and Predictive. Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. Isomorphic animals share the same symptoms and treatments, only. Predictive models are similar to a particular human disease in only a couple of aspects. However, these are useful in isolating and making predictions about mechanisms of a set of disease features.
The Oregon National Primate Research Center (ONPRC) is one of seven federally funded National Primate Research Centers in the United States and has been affiliated with Oregon Health and Science University (OHSU) since 1998. The center is located on 200 acres (0.81 km2) of land in Hillsboro, Oregon. Originally known as the Oregon Regional Primate Research Center (ORPRC), it was the first of the original seven primate centers established by the National Institutes of Health (NIH). The research center is administered and funded by the National Center for Research Resources, receiving $11 million in federal grants annually.
The domestic or domesticatedrabbit—more commonly known as a pet rabbit, bunny, bun, or bunny rabbit—is the domesticated form of the European rabbit, a member of the lagomorph family. A male rabbit is known as a buck, a female is a doe, and a young rabbit is a kit, or kitten.
Zoopharmacognosy is a behaviour in which non-human animals self-medicate by selecting and ingesting or topically applying plants, soils and insects with medicinal properties, to prevent or reduce the harmful effects of pathogens, toxins, and even other animals. The term derives from Greek roots zoo ("animal"), pharmacon, and gnosy ("knowing").
In 1985, a raid took place at a laboratory belonging to the University of California, Riverside (UCR) that resulted in the removal of a monkey by the Animal Liberation Front (ALF). This monkey, called Britches, was a stump-tailed macaque who was born into a breeding colony at UCR. He was removed from his mother at birth, had his eyelids sewn shut, and had an electronic sonar device attached to his head—a Trisensor Aid, an experimental version of a blind travel aid, the Sonicguide—as part of a three-year sensory-deprivation study involving 24 infant monkeys. The experiments were designed to study the behavioral and neural development of monkeys reared with a sensory substitution device.
The Silver Spring monkeys were 17 wild-born macaque monkeys from the Philippines who were kept in the Institute for Behavioral Research in Silver Spring, Maryland. From 1981 until 1991, they became what one writer called the most famous lab animals in history, as a result of a battle between animal researchers, animal advocates, politicians, and the courts over whether to use them in research or release them to a sanctuary. Within the scientific community, the monkeys became known for their use in experiments into neuroplasticity—the ability of the adult primate brain to reorganize itself.
Edward Taub is a behavioral neuroscientist on the faculty at the University of Alabama at Birmingham. He is best known for his involvement in the Silver Spring monkeys case, for making discoveries in the area of neuroplasticity, and developing constraint-induced movement therapy; a family of techniques which helps the rehabilitation of people who have developed learned non-use as a result of suffering neurological injuries from a stroke or other cause.
Cambridge University primate experiments came to public attention in 2002 after the publication that year of material from a ten-month undercover investigation in 1998 by the British Union for the Abolition of Vivisection (BUAV). The experiments were being conducted on marmosets, and included the removal of parts of their brains intended to simulate the symptoms of stroke or Parkinson's disease. Some of the research was theoretical, aimed at advancing knowledge of the brain, while some of it was applied.
Unnecessary Fuss is a film produced by People for the Ethical Treatment of Animals (PETA), showing footage shot inside the University of Pennsylvania's Head Injury Clinic in Philadelphia. The raw footage was recorded by the laboratory researchers as they inflicted brain damage to baboons using a hydraulic device. The experiments were conducted as part of a research project into head injuries such as is caused in vehicle accidents.
Experiments involving non-human primates (NHPs) include toxicity testing for medical and non-medical substances; studies of infectious disease, such as HIV and hepatitis; neurological studies; behavior and cognition; reproduction; genetics; and xenotransplantation. Around 65,000 NHPs are used every year in the United States, and around 7,000 across the European Union. Most are purpose-bred, while some are caught in the wild.
Animal psychopathology is the study of mental or behavioral disorders in non-human animals.
The Washington National Primate Research Center (WaNPRC) is a federally-funded biomedical research facility located on the University of Washington's Seattle campus. The WaNPRC is part of a network of seven National Primate Research Centers which conduct biomedical research on primates. The center opened in 1961, and as of 2020, houses over 500 primates.
The Wisconsin National Primate Research Center (WNPRC) is a federally funded biomedical research facility located at the University of Wisconsin-Madison. The WNPRC is part of a network of seven National Primate Research Centers which conduct biomedical research on primates. As of 2020, the center houses approximately 1,600 animals.
A euthanasia solution is a drug-containing aqueous solution for intentionally ending life to either relieve pain and suffering or execute convicts. The drugs used in euthanasia solution do not only need to be safe to personnel, but they also need to have a rapid onset of action and minimize the possible pain felt by humans and animals. To satisfy these requirements, the active ingredients in the euthanasia solution are usually anaesthetics, respiratory depressants, cardiotoxic drugs and cytotoxic drugs.
