Isotodesnitazene

Last updated

Isotodesnitazene
Isotodesnitazene structure.png
Identifiers
  • 2-[(4-isopropoxyphenyl)methyl]-1-(2-diethylaminoethyl)benzimidazole
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C23H31N3O
Molar mass 365.521 g·mol−1
3D model (JSmol)
  • CCN(CC)CCN1C2=CC=CC=C2N=C1CC3=CC=C(C=C3)OC(C)C
  • InChI=1S/C23H31N3O/c1-5-25(6-2)15-16-26-22-10-8-7-9-21(22)24-23(26)17-19-11-13-20(14-12-19)27-18(3)4/h7-14,18H,5-6,15-17H2,1-4H3
  • Key:MXCQZQAWFBUAJT-UHFFFAOYSA-N

Isotodesnitazene is a benzimidazole derivative which has potent opioid effects, having approximately 75x the potency of morphine. While isotodesnitazene itself appears to have been only rarely sold as a designer drug, numerous closely related compounds such as metodesnitazene, etodesnitazene, protodesnitazene, butodesnitazene, isotonitazene, isotonitazepyne and isotocyanozene have all been sold on the illicit market, so the pharmacological and analytical properties of isotodesnitazene have also been studied in the expectation that it may similarly become prominent at some point. [1] [2] [3] [4] [5] [6]

See also

References

  1. ↑ Taoussi O, Berardinelli D, Zaami S, Tavoletta F, Basile G, Kronstrand R, et al. (July 2024). "Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene". Archives of Toxicology. 98 (7): 2101–2116. Bibcode:2024ArTox..98.2101T. doi:10.1007/s00204-024-03735-0. PMC   11169013 . PMID   38582802.
  2. ↑ De Vrieze LM, Stove CP, Vandeputte MM (August 2024). "Nitazene test strips: a laboratory evaluation". Harm Reduction Journal. 21 (1) 159. doi: 10.1186/s12954-024-01078-8 . PMC   11350930 . PMID   39198843.
  3. ↑ Gatch MB, Hill RD, Sundar M, Shetty RA (July 2025). "Discriminative stimulus and antinociceptive effects of sixteen nitazene analogs in rodents". Neuropharmacology. 272 110416. doi:10.1016/j.neuropharm.2025.110416. PMID   40120927.
  4. ↑ Wachełko O, Tusiewicz K, Szpot P, Zawadzki M (August 2025). "The UHPLC-MS/MS method for the determination of 26 synthetic benzimidazole opioids (nitazene analogs) with isomers separation". Journal of Pharmaceutical and Biomedical Analysis. 260 116796. doi:10.1016/j.jpba.2025.116796. PMID   40068235.
  5. ↑ Hardwick EK, Couch AN, Davidson JT (March 2026). "Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool". Rapid Communications in Mass Spectrometry. 40 (5) e70004. doi:10.1002/rcm.70004. PMID   41359886.
  6. ↑ Man N, Chrzanowska A, Sutherland R, Sadaphale V, Barratt M, Bruno R, et al. (2025). Availability of nitazenes for purchase in Australia and internationally via cryptomarkets, September 2021 - August 2025 (Report). UNSW Sydney. doi:10.26190/unsworks/31698.
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