PAQR5

Last updated
PAQR5
Identifiers
Aliases PAQR5 , MPRG, progestin and adipoQ receptor family member 5
External IDs MGI: 1921340 HomoloGene: 9788 GeneCards: PAQR5
Gene location (Human)
Ideogram human chromosome 15.svg
Chr. Chromosome 15 (human) [1]
Human chromosome 15 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 15q23Start69,298,947 bp [1]
End69,407,780 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

54852

74090

Ensembl

ENSG00000137819

ENSMUSG00000032278

UniProt

Q9NXK6

Q9DCU0

RefSeq (mRNA)

NM_001104554
NM_017705

NM_028748

RefSeq (protein)

NP_001098024
NP_060175

NP_083024

Location (UCSC) Chr 15: 69.3 – 69.41 Mb Chr 9: 61.95 – 62.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Membrane progesterone receptor gamma (mPRγ), or progestin and adipoQ receptor 5 (PAQR5), is a protein that in humans is encoded by the PAQR5 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene Basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

See also

Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Unlike the progesterone receptor (PR), a nuclear receptor which mediates its effects via genomic mechanisms, mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades. The mPRs mediate important physiological functions in male and female reproductive tracts, liver, neuroendocrine tissues, and the immune system as well as in breast and ovarian cancer.

The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled receptor family. It includes at least 11 receptors (PAQR1–PAQR11), including the adiponectin (adipoQ) receptors (AdipoRs), the membrane progesterone receptors (mPRs), and others.

Related Research Articles

GUCY2D protein-coding gene in the species Homo sapiens

Retinal guanylyl cyclase 1 also known as guanylate cyclase 2D, retinal is an enzyme that in humans is encoded by the GUCY2D gene.

Adiponectin receptor 1 protein-coding gene in the species Homo sapiens

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene. It is a member of the progestin and adipoQ receptor family (PAQR), and is also known as PAQR1.

CELSR2 protein-coding gene in the species Homo sapiens

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.

GPR19 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene.

GPR158 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.

OR10Q1 protein-coding gene in the species Homo sapiens

Olfactory receptor 10Q1 is a protein that in humans is encoded by the OR10Q1 gene.

OR4Q3 protein-coding gene in the species Homo sapiens

Olfactory receptor 4Q3 is a protein that in humans is encoded by the OR4Q3 gene.

PAQR8 protein-coding gene in the species Homo sapiens

Membrane progesterone receptor beta (mPRβ), or progestin and adipoQ receptor 8 (PAQR8), is a protein that in humans is encoded by the PAQR8 gene.

MCOLN2 protein-coding gene in the species Homo sapiens

Mucolipin-2 also known as TRPML2 is a protein that in humans is encoded by the MCOLN2 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

Adiponectin receptor 2 protein-coding gene in the species Homo sapiens

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.

TAS2R42 protein-coding gene in the species Homo sapiens

Taste receptor, type 2, member 42 is a protein that in humans is encoded by the TAS2R42 gene.

GFRA4 protein-coding gene in the species Homo sapiens

GDNF family receptor alpha-4 (GFRα4), also known as the persephin receptor, is a protein that in humans is encoded by the GFRA4 gene.

PAQR7 protein-coding gene in the species Homo sapiens

Membrane progesterone receptor alpha (mPRα), or progestin and adipoQ receptor 7 (PAQR7), is a protein that in humans is encoded by the PAQR7 gene.

Srp receptor alpha subunit protein-coding gene in the species Homo sapiens

SRP receptor alpha subunit is a protein that in humans is encoded by the SRPRA gene.

IL17RD protein-coding gene in the species Homo sapiens

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.

PAQR9 protein-coding gene in the species Homo sapiens

Membrane progesterone receptor epsilon (mPRɛ), or progestin and adipoQ receptor 9 (PAQR9), is a protein that in humans is encoded by the PAQR9 gene.

PAQR6 protein-coding gene in the species Homo sapiens

Membrane progesterone receptor delta (mPRδ), or progestin and adipoQ receptor 6 (PAQR6), is a protein that in humans is encoded by the PAQR6 gene.

PGRMC2 protein-coding gene in the species Homo sapiens

Progesterone receptor membrane component 2 is a protein which is encoded by the PGRMC2 gene. It has been detected in the placenta, liver, and spermatozoa, among other areas.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137819 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032278 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: PAQR5 progestin and adipoQ receptor family member V".


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.