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18-Methylsegesterone acetate is a progestin medication of the 19-norprogesterone group which was never marketed. It was first described in a patent in 1997 and then in a literature paper in 2003. 18-Methyl-SGA is the C18 methyl or C13β ethyl derivative of segesterone acetate, and shows 3 to 10 times the progestogenic potency of SGA in bioassays. This is analogous to the case of the 19-nortestosterone progestin norethisterone and its 18-methyl derivative levonorgestrel, the latter showing substantially increased potency relative to the former similarly. As SGA is already one of the most potent progestins to have been developed, with 100-fold the potency of progesterone and 10-fold the potency of levonorgestrel in bioassays, 18-methyl-SGA is an extremely potent progestogen, among if not the most potent known.
Wang Yansi, courtesy name Jixian, was a Chinese orthodox Confucian and hermit during the Tang dynasty and Five Dynasties period. He was an adopted son and advisor to Wang Shenzhi, the first ruler of Min. Though most of his recommendations were ignored, he successfully convinced Wang Shenzhi against assuming imperial titles. After Wang Shenzhi's death, Wang Yansi went into retirement in the mountains when his adoptive brothers Wang Yanhan, Wang Yanbing and Wang Yanjun were engaged in fratricidal wars. Later in his life he taught Confucian classics and changed his name to Tang Yansi.
References
- ↑ Tsong at Ethnologue (18th ed., 2015)
- ↑ Jouni Filip Maho, 2009. New Updated Guthrie List Online
