Bracovirus

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Bracovirus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Viriform
Family: Polydnaviriformidae
Genus:Bracoviriform
Synonyms

Bracoviriform

  • BracoviriformICTV 2021
  • BracovirusICTV 1990
  • PolydnavirusICTV 1984

Bracovirus is a genus of viruses, in the family Polydnaviridae . Bracoviruses are an ancient symbiotic virus contained in parasitic braconid wasps that evolved off of the nudivirus about 190 million years ago and has been evolving at least 100 million years. [1] It is one of two genera belonging to the Polydnaviridae family, Ichnovirus being the other genus. There are 32 species in this genus. [2] [3]

Contents

Symbiosis

Parasitoid wasps in the subfamilies Microgastrinae, Miracinae, Cheloninae, Cardiochilinae, Khoikhoiinae, and Mendesellinae are the natural hosts for Bracoviruses, though the virus does not cause disease in these wasps. Instead, the wasps are themselves parasites of lepidoptera. The wasp injects one or more eggs into its lepidoptera host along with a quantity of virus. The virus does not replicate inside the wasp's host, but expression of viral genes prevents its immune system from killing the wasp's egg and causes other physiological alterations that ultimately cause the parasitized host to die. [2] Studies conducted on Cotesia congregata have shown that male wasps do contain proviral sequences of DNA, but the females are the ones responsible for the amplification of the viral DNA. [4]

Taxonomy

The genus Bracovirus contains the following 32 species; ICTV version 1999a-2020: [5]

The genus Bracoviriform contains the following 31 species starting ICTV version 2021 [3]

Structure

Viruses in Bracovirus are enveloped, with prolate ellipsoid and cylindrical geometries. Genomes are circular and segmented, around 2.0-31kb in length. The genome of the virus is enveloped with 35 double stranded DNA (dsDNA) all of which are circular. [2] [4]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
BracovirusProlate ellipsoidEnvelopedCircularSegmented

Life cycle

Viral replication is nuclear. DNA-templated transcription is the method of transcription. The virus exits the host cell by nuclear pore export. Transmission routes are parental. [2]

The replication of the Bracoviriform occurs within the ovaries of a parasitic wasps in calyx cells and is maintained by vertical transmission and to go into further detail the packaged genome of dsDNA is replicated inside of the wasp ovaries by development of the sequences of the virus from proviral segments in the tandem arrays in the wasp genome. The development of the sequences of Bracoviriform shows head-to-head and tail-to-tail sequences, which is unexpected, given that it has evolved from the nudivirus [4] The research conducted on Cotesia congregata shows that the viral genome contains one to three proviral segments. [4]

The virus like particle is transmitted into a lepidopteran host (a caterpillar) and infects and manipulates the physiology of the caterpillar so that it can be used as a living incubator for wasp larvae. When this happens the virus disrupts the caterpillar's immune system causing paralysis and inhibiting the pupating of the host. The arresting of the host increases the chance of success of the wasp larva developing successfully. [1]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
BracoviriformParasitoid wasps (Braconidae)Hemocytes; fat bodiesUnknownLysis; buddingNucleusNucleusUnknown

[2]

Related Research Articles

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<i>Polydnaviriformidae</i> Family of viruses

Polydnaviriformidae ( PDV) is a family of insect viriforms; members are known as polydnaviruses. There are two genera in the family: Bracoform and Ichnoviriform. Polydnaviruses form a symbiotic relationship with parasitoid wasps. Ichnoviriforms (IV) occur in Ichneumonid wasps and Bracoviriforms (BV) in Braconid wasps. The larvae of wasps in both of those groups are themselves parasitic on Lepidoptera, and the polydnaviruses are important in circumventing the immune response of their parasitized hosts. Little or no sequence homology exists between BV and IV, suggesting that the two genera have been evolving independently for a long time.

<span class="mw-page-title-main">Braconidae</span> Family of wasps

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<i>Cotesia congregata</i> Species of wasp

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Ichnovirus is a genus of viruses, in the family Polydnaviridae. Parasitoid wasps serve as hosts, and these wasps are themselves parasitoids of Lepidoptera. There are 21 species in this genus.

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References

  1. 1 2 "Oldest Viruses Infected Insects 300 Million Years Ago". Live Science . 12 September 2011.
  2. 1 2 3 4 5 "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. 1 2 "Virus Taxonomy: 2022 Release". International Committee on Taxonomy of Viruses (ICTV). March 2023. Retrieved 15 August 2023.
  4. 1 2 3 4 Louis, F.; Bezier, A.; Periquet, G.; Ferras, C.; Drezen, J.-M.; Dupuy, C. (2013). "The Bracovirus Genome of the Parasitoid Wasp Cotesia congregata is Amplified within 13 Replication Units, Including Sequences Not Packaged in the Particles" (PDF). Journal of Virology. 87 (17): 9649–9660. doi:10.1128/JVI.00886-13. PMC   3754133 . PMID   23804644.
  5. ↑ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2020. Retrieved 15 August 2023.
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