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Peritonitis is inflammation of the localized or generalized peritoneum, the lining of the inner wall of the abdomen and cover of the abdominal organs. Symptoms may include severe pain, swelling of the abdomen, fever, or weight loss. One part or the entire abdomen may be tender. Complications may include shock and acute respiratory distress syndrome.
Enterococcus is a large genus of lactic acid bacteria of the phylum Firmicutes. Enterococci are gram-positive cocci that often occur in pairs (diplococci) or short chains, and are difficult to distinguish from streptococci on physical characteristics alone. Two species are common commensal organisms in the intestines of humans: E. faecalis (90–95%) and E. faecium (5–10%). Rare clusters of infections occur with other species, including E. casseliflavus, E. gallinarum, and E. raffinosus.
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). The term can also refer more generally to any organic molecule that contains amino sugar substructures. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.
A blood culture is a medical laboratory test used to detect bacteria or fungi in a person's blood. Under normal conditions, the blood does not contain microorganisms: their presence can indicate a bloodstream infection such as bacteremia or fungemia, which in severe cases may result in sepsis. By culturing the blood, microbes can be identified and tested for resistance to antimicrobial drugs, which allows clinicians to provide an effective treatment.
Escherichia is a genus of Gram-negative, non-spore-forming, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae. In those species which are inhabitants of the gastrointestinal tracts of warm-blooded animals, Escherichia species provide a portion of the microbially derived vitamin K for their host. A number of the species of Escherichia are pathogenic. The genus is named after Theodor Escherich, the discoverer of Escherichia coli. Escherichia are facultative aerobes, with both aerobic and anaerobic growth, and an optimum temperature of 37 °C. Escherichia are usually motile by flagella, produce gas from fermentable carbohydrates, and do not decarboxylate lysine or hydrolyze arginine. Species include E. albertii, E. fergusonii, E. hermannii, E. marmotae and most notably, the model organism and clinically relevant E. coli. Shimwellia blattae was formerly classified in this genus.
Tigecycline, sold under the brand name Tygacil, is an tetracycline antibiotic medication for a number of bacterial infections. It is a glycylcycline administered intravenously. It was developed in response to the growing rate of antibiotic resistant bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include Gram-positive and Gram-negative organisms, including those of multi-drug resistance.
Ampicillin/sulbactam is a fixed-dose combination medication of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist. The first, developed in 1987 and marketed in the United States under the brand name Unasyn, generic only outside the United States, is an intravenous antibiotic. The second, an oral form called sultamicillin, is marketed under the brand name Ampictam outside the United States. And generic only in the United States, ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.
Peptostreptococcus is a genus of anaerobic, Gram-positive, non-spore forming bacteria. The cells are small, spherical, and can occur in short chains, in pairs or individually. They typically move using cilia. Peptostreptococcus are slow-growing bacteria with increasing resistance to antimicrobial drugs. Peptostreptococcus is a normal inhabitant of the healthy lower reproductive tract of women.
Gemella morbillorum is a species of bacteria within the genus Gemella. It is a facultative anaerobic Gram positive coccus usually preferring capnophilic or microaerophilic environments. From its discovery in 1917 until 1988, it was known as Streptococcus morbillorum. The name change followed closer examination with DNA filter hybridization which found it was very close to the species Gemella haemolysans.
The Peptostreptococcaceae are a family of Gram-positive bacteria in the class Clostridia.
Oritavancin, sold under the brand name Orbactiv among others, is a semisynthetic glycopeptide antibiotic medication for the treatment of serious Gram-positive bacterial infections. Its chemical structure as a lipoglycopeptide is similar to vancomycin.
Enterobacter cloacae is a clinically significant Gram-negative, facultatively-anaerobic, rod-shaped bacterium.
Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. It was synthesized in order to create an antibiotic with a broader spectrum. It is often grouped with the second-generation cephalosporins. Cefoxitin requires a prescription and as of 2010 is sold under the brand name Mefoxin by Bioniche Pharma, LLC. The generic version of cefoxitin is known as cefoxitin sodium.
Etest is a way of determining antimicrobial sensitivity by placing a strip impregnated with antimicrobials onto an agar plate. A strain of bacterium or fungus will not grow near a concentration of antibiotic or antifungal if it is sensitive. For some microbial and antimicrobial combinations, the results can be used to determine a minimum inhibitory concentration (MIC). Etest is a proprietary system manufactured by bioMérieux. It is a laboratory test used in healthcare settings to help guide physicians by indicating what concentration of antimicrobial could successfully be used to treat patients' infections.
Anaerobic infections are caused by anaerobic bacteria. Obligately anaerobic bacteria do not grow on solid media in room air ; facultatively anaerobic bacteria can grow in the presence or absence of air. Microaerophilic bacteria do not grow at all aerobically or grow poorly, but grow better under 10% carbon dioxide or anaerobically. Anaerobic bacteria can be divided into strict anaerobes that can not grow in the presence of more than 0.5% oxygen and moderate anaerobic bacteria that are able of growing between 2 and 8% oxygen. Anaerobic bacteria usually do not possess catalase, but some can generate superoxide dismutase which protects them from oxygen.
Infections caused by exposure to ionizing radiation can be extremely dangerous, and are of public and government concern. Numerous studies have demonstrated that the susceptibility of organisms to systemic infection increased following exposure to ionizing radiation. The risk of systemic infection is higher when the organism has a combined injury, such as a conventional blast, thermal burn, or radiation burn. There is a direct quantitative relationship between the magnitude of the neutropenia that develops after exposure to radiation and the increased risk of developing infection. Because no controlled studies of therapeutic intervention in humans are available, almost all of the current information is based on animal research.
Peptoniphilus is a genus of bacteria in the phylum Bacillota (Bacteria).
Anaerococcus is a genus of bacteria. Its type species is Anaerococcus prevotii. These bacteria are Gram-positive and strictly anaerobic. The genus Anaerococcus was proposed in 2001. Its genome was sequenced in August 2009. The genus Anaerococcus is one of six genera classified within the group GPAC. These six genera are found in the human body as part of the commensal human microbiota.
Granulicatella adiacens is a fastidious Gram-positive cocci and is part of the nutritionally variant streptococci (NVS). Like other constituents of the NVS, it can cause bacteremia and infective endocarditis (IE), with significant morbidity and mortality. NVS has less often been implicated in a variety of other infections, including those of the orbit, nasolacrimal duct and breast implants. It is a commensal of the human mouth, genital, and intestinal tracts, although it is rarely implicated in infections, in part due to it being a fastidious organism and rarely being identified in the laboratory environment. However, its identification has become more frequent with use of commercial mediums and automated identification systems. Because it has been difficult to identify, it has been considered one of the causes of culture negative IE. Identifying G. adiacens can allow more appropriate selection of antibiotics, especially when susceptibility testing is not available.
Sydney "Sid" Martin Finegold was an American physician, medical school professor, and medical researcher, specializing in anaerobic bacteriology.
References
- 1 2 "Finegoldia". LPSN . Retrieved 2016-01-06.
- ↑ Murdoch, D. A; Shah, H. N (1999-10-01). "Reclassification of Peptostreptococcus magnus (Prevot 1933) Holdeman and Moore 1972 as Finegoldia magna comb. nov. and Peptostreptococcus micros (Prevot 1933) Smith 1957 as Micromonas micros comb. nov". Anaerobe. 5 (5): 555–559. doi:10.1006/anae.1999.0197.
- 1 2 3 John e. Bennett, MD; Raphael Dolin, MD; Martin j. Blaser, MD (2014-08-28). "Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli". Mandell, Douglas, and Bennett's principles and practice of infectious diseases. ISBN 978-1-4557-4801-3.
- ↑ de Moreuil, Claire; Héry-Arnaud, Geneviève; David, Charles-Henri; Provost, Bastien; Mondine, Philippe; Alavi, Zarrin; de Saint Martin, Luc; Bezon, Eric; Berre, Rozenn Le (2015-04-01). "Finegoldia magna, not a well-known infectious agent of bacteriemic post-sternotomy mediastinitis". Anaerobe. 32: 32–33. doi:10.1016/j.anaerobe.2014.11.012. PMID 25448620.
- 1 2 Veloo, A. C. M.; Welling, G. W.; Degener, J. E. (2011-03-01). "Antimicrobial Susceptibility of Clinically Relevant Gram-Positive Anaerobic Cocci Collected over a Three-Year Period in the Netherlands". Antimicrobial Agents and Chemotherapy. 55 (3): 1199–1203. doi:10.1128/AAC.01771-09. ISSN 0066-4804. PMC 3067104 . PMID 21189338.
- ↑ Brazier, J. S.; Hall, V.; Morris, T. E.; Gal, M.; Duerden, B. I. (2003-08-01). "Antibiotic susceptibilities of Gram-positive anaerobic cocci: results of a sentinel study in England and Wales". Journal of Antimicrobial Chemotherapy. 52 (2): 224–228. doi: 10.1093/jac/dkg316 . ISSN 0305-7453. PMID 12837734.