Lithium lactate

Last updated
Lithium lactate
Lithium lactate.svg
Names
Other names
Lithium 2-hydroxypropanoate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.011.602 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 212-761-8
PubChem CID
  • InChI=1S/C3H6O3.Li/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1
    Key: GKQWYZBANWAFMQ-UHFFFAOYSA-M
  • [Li+].CC(C(=O)[O-])O
Properties
C
3H
5LiO
3 [1] [2]
Molar mass 96.01
AppearanceAmorphous solid
Density g/cm3
Melting point 300 °C (572 °F; 573 K)
Very soluble
Hazards
GHS labelling: [3]
GHS-pictogram-exclam.svg
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Related compounds
Other cations
Sodium lactate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Lithium lactate is a chemical compound, a salt of lithium and lactic acid with the formula CH3CH(OH)COOLi, [4] an amorphous solid, very soluble in water. [5]

Contents

Synthesis

Synthesis is by neutralization of lactic acid with lithium hydroxide:

LiOH + CH3CH(OH)COOH → CH3CH(OH)COOLi + H2O

Physical properties

Lithium lactate forms an amorphous solid.

It dissolves very well in water [6] and organic solvents.

The compound demonstrates optical isomerism.

Lithium lactate emits acrid smoke when heated to decomposition. [7]

Chemical properties

Lithium lactate reacts with triphosgene to obtain lactic acid-O-internal anhydride. [8] It can be used as a precursor to prepare Li4SiO4, [9] Li4Ti5O12/C [10] and other materials.

Use

Lithium lactate is part of drugs that promote the excretion of uric acid from the body. [11] This is linked to a historical use of lithium to help remove uric acid, but it was later shown that doses needed for it to work would be toxic. [12]

It is also used as a mood stabilizer. [13] [ failed verification ]

References

  1. ↑ "867-55-0 CAS | LITHIUM LACTATE | Laboratory Chemicals | Article No. 04444". Loba Chemie. Retrieved 17 January 2022.
  2. ↑ "27848-80-2 - L-(+)-Lactic acid lithium salt, Thermo Scientific - Lithium Lactate - J18160 - Alfa Aesar". Alfa Aesar . Retrieved 17 January 2022.
  3. ↑ "Lithium lactate". pubchem.ncbi.nlm.nih.gov. Retrieved 22 January 2022.
  4. ↑ "Lithium Lactate". American Elements . Retrieved 17 January 2022.
  5. ↑ "Lithium lactate". Sigma Aldrich . Retrieved 17 January 2022.
  6. ↑ Lewis, Robert A. (31 May 2016). Hawley's Condensed Chemical Dictionary. John Wiley & Sons. p. 840. ISBN   978-1-118-13515-0 . Retrieved 17 January 2022.
  7. ↑ Lewis, Richard J. (13 June 2008). Hazardous Chemicals Desk Reference. John Wiley & Sons. p. 844. ISBN   978-0-470-18024-2 . Retrieved 17 January 2022.
  8. ↑ Nölle, Roman; Schmiegel, Jan-Patrick; Winter, Martin; Placke, Tobias (14 January 2020). "Tailoring Electrolyte Additives with Synergistic Functional Moieties for Silicon Negative Electrode-Based Lithium Ion Batteries: A Case Study on Lactic Acid O-Carboxyanhydride" . Chemistry of Materials . 32 (1): 173–185. doi:10.1021/acs.chemmater.9b03173. ISSN   0897-4756. S2CID   213665815 . Retrieved 23 January 2022.
  9. ↑ Yang, Xinwei; Liu, Wenqiang; Sun, Jian; Hu, Yingchao; Wang, Wenyu; Chen, Hongqiang; Zhang, Yang; Li, Xian; Xu, Minghou (2016). "Preparation of Novel Li4SiO4 Sorbents with Superior Performance at Low CO2 Concentration" . ChemSusChem . 9 (13): 1607–1613. doi:10.1002/cssc.201501699. ISSN   1864-564X. PMID   27312486 . Retrieved 23 January 2022.
  10. ↑ Stenina, I. A.; Sobolev, A. N.; Kuz’mina, A. A.; Kulova, T. L.; Yaroslavtsev, A. B. (1 August 2019). "Effect of the Carbon Source on the Electrochemical Properties of Li4Ti5O12/C Composites Prepared by Solid-State Synthesis" . Inorganic Materials. 55 (8): 803–809. doi:10.1134/S0020168519080156. ISSN   1608-3172. S2CID   201715779 . Retrieved 23 January 2022.
  11. ↑ Handler, J. S. (October 1, 1960). "The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy". The Journal of Clinical Investigation. 39 (10): 1526–1532. doi:10.1172/JCI104172. ISSN   0021-9738. PMC   441887 . PMID   13711188.
  12. ↑ Marmol F (December 2008). "Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 32 (8): 1761–1771. doi:10.1016/j.pnpbp.2008.08.012. PMID   18789369. S2CID   25861243.
  13. ↑ Wang, Quan; Xu, Xinxiu; Li, Jun; Liu, Jing; Gu, Haifeng; Zhang, Ru; Chen, Jiekai; Kuang, Yin; Fei, Jian; Jiang, Cong; Wang, Ping; Pei, Duanqing; Ding, Sheng; Xie, Xin (July 5, 2011). "Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells". Cell Research. 21 (10): 1424–1435. doi:10.1038/cr.2011.108. ISSN   1748-7838. PMC   3193456 . PMID   21727907.
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