Hippocalcin

HPCA
Identifiers
Aliases	HPCA , BDR2, DYT2, hippocalcin
External IDs	OMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.1 Start 32,885,994 bp [1] End 32,898,441 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 129,005,363 bp [2] End 129,015,829 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus middle frontal gyrus putamen nucleus accumbens external globus pallidus prefrontal cortex Region I of hippocampus proper Brodmann area 10 dorsolateral prefrontal cortex cingulate gyrus Top expressed in superior frontal gyrus olfactory tubercle hippocampus proper Region I of hippocampus proper nucleus accumbens globus pallidus primary motor cortex prefrontal cortex superior colliculus entorhinal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding actin binding calcium ion binding identical protein binding kinase binding Cellular component perikaryon dendrite membrane neuronal cell body membrane axon dendritic spine head dendrite cytoplasm cytosol extrinsic component of membrane cytoplasm membrane postsynapse glutamatergic synapse Biological process positive regulation of adenylate cyclase activity response to organic cyclic compound cellular response to monosodium glutamate negative regulation of guanylate cyclase activity positive regulation of phospholipase activity activation of phospholipase D activity brain development retina development in camera-type eye response to ketamine response to L-glutamate inner ear development response to Aroclor 1254 calcium-mediated signaling positive regulation of protein targeting to membrane cellular response to electrical stimulus cellular response to calcium ion regulation of voltage-gated calcium channel activity regulation of postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3208 15444 Ensembl ENSG00000121905 ENSMUSG00000028785 UniProt P84074 P84075 RefSeq (mRNA) NM_002143 NM_001130419 NM_010471 NM_001286081 NM_001286083 RefSeq (protein) NP_002134 NP_001123891 NP_001273010 NP_001273012 NP_034601 Location (UCSC) Chr 1: 32.89 – 32.9 Mb Chr 4: 129.01 – 129.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hippocalcin is a protein that in humans is encoded by the HPCA gene. ^{[5] [6]}

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. ^{[7] [8]} It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch. ^[9]

Processes

Hippocalcin takes part in the following processes:

• Activation of PLD1 and PLD2 expression
• Inhibition of apoptosis
• MAP kinase signalling
• Involved in long term depression in hippocampal neuron
• Required for normal spatial learning

Interactions

Hippocalcin interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)
• Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
• The b2 adaptin of the AP2 complex
• Calcium-dependent activator protein for secretion (CADPS)

References

1. GRCh38: Ensembl release 89: ENSG00000121905 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028785 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID   8166736.
6. Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene. 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID   9931466.
7. Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC   1887812 . PMID   17311005.
8. Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID   15046879. S2CID   24156457.
9. O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC   2173692 . PMID   14638856.

Further reading

• Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID   8387172. S2CID   4210072.
• Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. Neurol. Sci. 281 (1–2): 51–4. doi:10.1016/j.jns.2009.02.375. PMID   19332348. S2CID   13177773.
• Kobayashi M, Takamatsu K, Saitoh S, et al. (1992). "Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus". Biochem. Biophys. Res. Commun. 189 (1): 511–7. doi:10.1016/0006-291X(92)91587-G. PMID   1280427.
• Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC   1170366 . PMID   9427749.
• Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. doi: 10.1016/S0021-9258(17)46711-1 . PMID   8360179.
• Rudinskiy N, Kaneko YA, Beesen AA, et al. (2009). "Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons". J. Neurochem. 111 (2): 460–72. doi: 10.1111/j.1471-4159.2009.06344.x . PMID   19686238.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC   313967 . PMID   10899114.
• Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC   1222513 . PMID   11964161.
• O'Callaghan DW, Haynes LP, Burgoyne RD (2005). "High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate". Biochem. J. 391 (Pt 2): 231–8. doi:10.1042/BJ20051001. PMC   1276920 . PMID   16053445.
• O'Callaghan DW, Ivings L, Weiss JL, et al. (2002). "Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction". J. Biol. Chem. 277 (16): 14227–37. doi: 10.1074/jbc.M111750200 . PMID   11836243.
• Markova 0, Fitzgerald D, Stepanyuk A; et al. (2009). "Hippocalcin signaling via site-specific translocation in hippocampal neurons". Neurosci. Lett. 442 (2): 152–7. doi:10.1016/j.neulet.2008.06.089. PMC   2572729 . PMID   18634855.

External links

• NCS proteins