Bordetella parapertussis

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Bordetella parapertussis
Scientific classification Red Pencil Icon.png
Domain: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
B. parapertussis
Binomial name
Bordetella parapertussis
(Eldering and Kendrick 1938) Moreno-López 1952

Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian respiratory tract. [1] Pertussis caused by B. parapertussis manifests with similar symptoms to B. pertussis -derived disease, but in general tends to be less severe. [2] Immunity derived from B. pertussis does not protect against infection by B. parapertussis, however, because the O-antigen is found only on B. parapertussis. This antigen protects B. parapertussis against antibodies specific to B. pertussis, so the bacteria are free to colonize the host's lungs without being subject to attack by previous antibodies. These findings suggest B. parapertussis evolved in a host population that had already developed immunity to B. pertussis, where being able to evade B. pertussis immunity was an advantage. [3]

<i>Bordetella</i> genus of bacteria

Bordetella is a genus of small, Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described ; are sometimes referred to as the 'classical species'. One of these is also motile.

<i>Bordetella pertussis</i> species of bacterium

Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. Unlike B. bronchiseptica, B. pertussis is not motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin, pertactin, fimbria, and tracheal cytotoxin.

Two lineages of B. parapertussis have been described. The first infects humans and is responsible for a minority of cases of the disease pertussis (also known as whooping cough). [4] The second, ovine, lineage causes chronic nonprogressive pneumonia in sheep. [5] Both lineages are thought to have evolved from a B. bronchiseptica -like ancestor. [6] This disease can be symptomatic or asymptomatic and may predispose hosts to secondary infection. [7]

Pneumonia inflammatory condition of the lung

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli. Typically symptoms include some combination of productive or dry cough, chest pain, fever, and trouble breathing. Severity is variable.

<i>Bordetella bronchiseptica</i> species of bacterium

Bordetella bronchiseptica is a small, Gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious bronchitis in dogs and other animals, but rarely infects humans. Closely related to B. pertussis—the obligate human pathogen that causes pertussis ; B. bronchiseptica can persist in the environment for extended periods.

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Immune system A biological system that protects an organism against disease

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity. In humans, the blood–brain barrier, blood–cerebrospinal fluid barrier, and similar fluid–brain barriers separate the peripheral immune system from the neuroimmune system, which protects the brain.

Infection invasion of a host by disease-causing organisms

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce. Infectious disease, also known as transmissible disease or communicable disease, is illness resulting from an infection.

<i>Streptococcus pyogenes</i> Species of bacterium

Streptococcus pyogenes is a species of Gram-positive bacterium in the genus Streptococcus. These bacteria are aerotolerant and an extracellular bacterium, made up of non-motile and non-sporing cocci. It is clinically important for humans. It is an infrequent, but usually pathogenic, part of the skin microbiota. It is the predominant species harboring the Lancefield group A antigen, and is often called group A streptococcus (GAS). However, both Streptococcus dysgalactiae and the Streptococcus anginosus group can possess group A antigen. Group A streptococci when grown on blood agar typically produces small zones of beta-hemolysis, a complete destruction of red blood cells. It is thus also called group A (beta-hemolytic) streptococcus (GABHS), and can make colonies greater than 5 mm in size.

Whooping cough human disease caused by the bacteria Bordetella pertussis

Whooping cough is a highly contagious bacterial disease. Initially, symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough. This is followed by weeks of severe coughing fits. Following a fit of coughing, a high-pitched whoop sound or gasp may occur as the person breathes in. The coughing may last for 10 or more weeks, hence the phrase "100-day cough". A person may cough so hard that they vomit, break ribs, or become very tired from the effort. Children less than one year old may have little or no cough and instead have periods where they do not breathe. The time between infection and the onset of symptoms is usually seven to ten days. Disease may occur in those who have been vaccinated, but symptoms are typically milder.

<i>Haemophilus influenzae</i> species of bacterium

Haemophilus influenzae is a Gram-negative, coccobacillary, facultatively anaerobic pathogenic bacterium belonging to the Pasteurellaceae family. H. influenzae was first described in 1892 by Richard Pfeiffer during an influenza pandemic.

<i>Onchocerca volvulus</i> species of parasitic nematode, cause of river blindness in humans

Onchocerca volvulus is a nematode that causes onchocerciasis, and is the second leading cause of blindness worldwide after trachoma. It is one of the twenty neglected tropical diseases listed by the World Health Organization (WHO), with elimination from certain countries expected by 2020.

Pertussis toxin

Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral infection, and autoimmunity.

Bartonellosis is an infectious disease produced by bacteria of the genus Bartonella. Bartonella species cause diseases such as Carrión´s disease, trench fever, cat-scratch disease, bacillary angiomatosis, peliosis hepatis, chronic bacteremia, endocarditis, chronic lymphadenopathy, and neurological disorders.

<i>Influenza C virus </i> genus of viruses

Influenza C virus is the species in the genus Influenzavirus C in the virus family Orthomyxoviridae, which like other influenza viruses, causes influenza.

Subclinical infection

A subclinical infection is an infection that, being subclinical, is nearly or completely asymptomatic. A subclinically infected person is thus an asymptomatic carrier of a microbe, intestinal parasite, or virus that usually is a pathogen causing illness, at least in some individuals. Many pathogens spread by being silently carried in this way by some of their host population. Such infections occur both in humans and nonhuman animals. An example of an asymptomatic infection is a mild common cold that is not noticed by the infected individual. Since subclinical infections often occur without eventual overt sign, their existence is only identified by microbiological culture or DNA techniques such as polymerase chain reaction.

<i>Sporothrix schenckii</i> species of fungus

Sporothrix schenckii is a fungus that can be found worldwide in the environment. The species is present in soil as well as in and on living and decomposing plant material such as peat moss. It can infect humans as well as animals and is the causative agent of sporotrichosis, commonly known as "rose handler's disease". The most common route of infection is the introduction of spores to the body through a cut or puncture wound in the skin. Infection commonly occurs in otherwise healthy individuals but is rarely life-threatening and can be treated with antifungals. In the environment it is found growing as filamentous hyphae. In host tissue it is found as a yeast. The transition between the hyphal and yeast forms is temperature dependent making S. schenckii a thermally dimorphic fungus.

The AB5 toxins are six-component protein complexes secreted by certain pathogenic bacteria known to cause human diseases such as cholera, dysentery, and hemolytic-uremic syndrome. One component is known as the A subunit, and the remaining five components are B subunits. All of these toxins share a similar structure and mechanism for entering targeted host cells. The B subunit is responsible for binding to receptors to open up a pathway for the A subunit to enter the cell. The A subunit is then able to use its catalytic machinery to take over the host cell's regular functions.

Lyme disease microbiology

Lyme disease, or borreliosis, is caused by spirochetal bacteria from the genus Borrelia, which has 52 known species. Three main species are the main causative agents of the disease in humans, while a number of others have been implicated as possibly pathogenic. Borrelia species in the species complex known to cause Lyme disease are collectively called Borrelia burgdorferisensu lato (s.l.) not to be confused with the single species in that complex Borrelia burgdorferi sensu stricto which is responsible for all cases of Lyme disease in North America.

Mycoplasma ovipneumoniae is a species of Mycoplasma bacteria that most commonly inhabits and affects ovine animals. M. ovipneumoniae is a respiratory pathogen of domestic sheep, domestic goats, bighorn sheep, mountain goats, and other caprinae that can both cause primary atypical pneumonia and also predispose infected animals to secondary pneumonia with other agents, including Mannheimia haemolytica. Several mechanisms are involved in the pathogenicity of M. ovipneumoniae, including altering macrophage activity, adhering to the ruminants' ciliated epithelium via its polysaccharide capsule, inducing the production of autoantibodies to cilary antigens, and suppressive activity on lymphocytes, all of which are important factors that contribute to the disease in sheep and other small ruminants. The bacterium also has the ability to act as a prediposing factor for other bacterial and viral infections.

A pneumococcal infection is an infection caused by the bacterium Streptococcus pneumoniae, which is also called the pneumococcus. S. pneumoniae is a common member of the bacterial flora colonizing the nose and throat of 5–10% of healthy adults and 20–40% of healthy children. However, it is also a cause of significant disease, being a leading cause of pneumonia, bacterial meningitis, and sepsis. The World Health Organization estimate that in 2005 pneumococcal infections were responsible for the death of 1.6 million children worldwide.

Tracheal cytotoxin

Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis and Neisseria gonorrhoeae.

<i>Influenza D virus </i>

Influenza D virus is a species in the virus genus Influenzavirus D in the family Orthomyxoviridae, that causes influenza.


  1. Ryan KJ; Ray CG, eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN   978-0-8385-8529-0.
  2. Heininger U, Stehr K, Schmitt-Grohé S, Lorenz C, Rost R, Christenson P, Uberall M, Cherry J (1994). "Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis". Pediatr Infect Dis J. 13 (4): 306–9. doi:10.1097/00006454-199404000-00011. PMID   8036048.
  3. Wolfe D, Goebel E, Bjornstad O, Restif O, Harvil E (2007). "The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity". Infection and Immunity. 75 (10): 4972–9. doi:10.1128/IAI.00763-07. PMC   2044517 . PMID   17698566.
  4. Cherry J (1996). "Historical review of pertussis and the classical vaccine". J Infect Dis. 174 Suppl 3: S259–63. doi:10.1093/infdis/174.supplement_3.s259. PMID   8896526.
  5. Porter J, Connor K, Donachie W (1994). "Isolation and characterization of Bordetella parapertussis-like bacteria from ovine lungs". Microbiology. 140 (2): 255–61. doi:10.1099/13500872-140-2-255. PMID   8180690.
  6. van der Zee A, Mooi F, Van Embden J, Musser J (1997). "Molecular evolution and host adaptation of Bordetella spp.: phylogenetic analysis using multilocus enzyme electrophoresis and typing with three insertion sequences". J Bacteriol. 179 (21): 6609–17. doi:10.1128/jb.179.21.6609-6617.1997. PMC   179586 . PMID   9352907.
  7. Porter J, Connor K, Krueger N, Hodgson J, Donachie W (1995). "Predisposition of specific pathogen-free lambs to Pasteurella haemolytica pneumonia by Bordetella parapertussis infection". J Comp Pathol. 112 (4): 381–9. doi:10.1016/S0021-9975(05)80019-2. PMID   7593760.