Klebsiella granulomatis | |
---|---|
Scientific classification | |
Domain: | Bacteria |
Phylum: | Pseudomonadota |
Class: | Gammaproteobacteria |
Order: | Enterobacterales |
Family: | Enterobacteriaceae |
Genus: | Klebsiella |
Species: | K. granulomatis |
Binomial name | |
Klebsiella granulomatis (Aragão and Vianna 1913) Carter et al. 1999 | |
Klebsiella granulomatis is a Gram-negative, rod-shaped bacterium of the genus Klebsiella [1] known to cause the sexually transmitted infection granuloma inguinale (or donovanosis). It was formerly called Calymmatobacterium granulomatis. [2]
It is a non-motile aerobic bacillus with a non-sporulated capsule measuring 0.5 to 2.0 μm. [3] [4] It is biochemically characterised by being as catalase-positive, phenylalanine deaminase-negative, citrate test-positive, and urease-positive. [5] Among its virulence factors are its capsule, endotoxins, siderophores, antimicrobial resistance and antigenic phase variation. [6]
The incubation period lasts around 50 days, may vary between 1 and 12 weeks. [7]
This rare form of genital ulceration is on the verge of being eradicated worldwide. There are currently alarming figures in areas such as India, Papua New Guinea, the Caribbean, South America, Zambia, Zimbabwe, South Africa and Australia. [8]
Thanks to the recognition as a public health problem and appropriate control measures such as the implementation of better health service provisions, the incidence of this microorganism in countries such as Papua New Guinea, South Africa, India and the Caribbean has decreased significantly. [8]
Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. Most people who are infected have no symptoms. When symptoms do appear they may occur only several weeks after infection; the incubation period between exposure and being able to infect others is thought to be on the order of two to six weeks. Symptoms in women may include vaginal discharge or burning with urination. Symptoms in men may include discharge from the penis, burning with urination, or pain and swelling of one or both testicles. The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy.
Lymphogranuloma venereum is a sexually transmitted infection caused by the invasive serovars L1, L2, L2a, L2b, or L3 of Chlamydia trachomatis.
Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results in small raised pink lesions with a dimple in the center. They may become itchy or sore, and occur singularly or in groups. Any area of the skin may be affected, with abdomen, legs, arms, neck, genital area, and face being the most common. Onset of the lesions is around seven weeks after infection. They usually go away within a year without scarring.
Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis characterized by genital ulcers. It is endemic in many less-developed regions. It is also known as donovanosis, granuloma genitoinguinale, granuloma inguinale tropicum, granuloma venereum, granuloma venereum genitoinguinale, lupoid form of groin ulceration, serpiginous ulceration of the groin, ulcerating granuloma of the pudendum, and ulcerating sclerosing granuloma. Oral manifestations are also notably seen. The lesions of oral cavity are usually secondary to active genital lesions.
The infrahyoid muscles, or strap muscles, are a group of four pairs of muscles in the anterior (frontal) part of the neck. The four infrahyoid muscles are the sternohyoid, sternothyroid, thyrohyoid and omohyoid muscles.
The viridans streptococci are a large group of commensal streptococcal Gram-positive bacteria species that are α-hemolytic, producing a green coloration on blood agar plates, although some species in this group are actually γ-hemolytic, meaning they produce no change on blood agar. The pseudo-taxonomic term "Streptococcus viridans" is often used to refer to this group of species, but writers who do not like to use the pseudotaxonomic term prefer the terms viridans streptococci, viridans group streptococci (VGS), or viridans streptococcal species.
The nasolacrimal duct carries tears from the lacrimal sac of the eye into the nasal cavity. The duct begins in the eye socket between the maxillary and lacrimal bones, from where it passes downwards and backwards. The opening of the nasolacrimal duct into the inferior nasal meatus of the nasal cavity is partially covered by a mucosal fold.
Klebsiella is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.
The bacterial capsule is a large structure common to many bacteria. It is a polysaccharide layer that lies outside the cell envelope, and is thus deemed part of the outer envelope of a bacterial cell. It is a well-organized layer, not easily washed off, and it can be the cause of various diseases.
Mycoplasmataceae is a family of bacteria in the order Mycoplasmatales. This family consists of the genera Mycoplasma and Ureaplasma.
Coliform bacteria are defined as either motile or non-motile Gram-negative non-spore forming bacilli that possess β-galactosidase to produce acids and gases under their optimal growth temperature of 35–37 °C. They can be aerobes or facultative aerobes, and are a commonly used indicator of low sanitary quality of foods, milk, and water. Coliforms can be found in the aquatic environment, in soil and on vegetation; they are universally present in large numbers in the feces of warm-blooded animals as they are known to inhabit the gastrointestinal system. While coliform bacteria are not normally causes of serious illness, they are easy to culture, and their presence is used to infer that other pathogenic organisms of fecal origin may be present in a sample, or that said sample is not safe to consume. Such pathogens include disease-causing bacteria, viruses, or protozoa and many multicellular parasites.
The chordae tendineae or tendinous cords, colloquially known as the heart strings, are inelastic cords of fibrous connective tissue that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart.
Venereology is a branch of medicine that is concerned with the study and treatment of sexually transmitted diseases (STDs). The name derives from Roman goddess Venus, associated with love, beauty and fertility. A physician specializing in venereology is called a venereologist. In many areas of the world, the specialty is usually combined with dermatology.
The bare area of the liver is a large triangular area on the diaphragmatic surface of the liver. It is the only part of the liver with no peritoneal covering, although it is still covered by Glisson's capsule. It is attached directly to the diaphragm by loose connective tissue. The bare area of the liver is relevant to the portacaval anastomosis, encloses the right extraperitoneal subphrenic space, and can be a site of spread of infection from the abdominal cavity to the thoracic cavity
Lieutenant Colonel Charles Donovan was an Irish physician, parasitologist and entomologist who served as a medical officer in the Indian Medical Service. He is best remembered for his discoveries of Leishmania donovani as the causative agent of visceral leishmaniasis, and Klebsiella granulomatis as that of donovanosis. The son of a judge in India, he was born in Calcutta and completed his primary education in India, and continued secondary school in Cork, Ireland. He graduated in medicine from Queen's College, Cork and joined the Indian Medical Service. He participated in British expeditions to Mandalay in Burma, Royapuram and Mangalore in India, Afghanistan, and finally Madras, where he spent the rest of his service. He was professor at Madras Medical College from 1898 until his retirement in 1919.
In most terrestrial mammals, the scrotum or scrotal sac is a part of the external male genitalia located at the base of the penis that consists of a suspended dual-chambered sac of skin and smooth muscle. The scrotum contains the external spermatic fascia, testicles, epididymides, and vasa deferentia. It is a distention of the perineum and carries some abdominal tissues into its cavity including the testicular artery, testicular vein, and pampiniform plexus. The perineal raphe is a small, vertical, slightly raised ridge of scrotal skin under which is found the scrotal septum. It appears as a thin longitudinal line that runs front to back over the entire scrotum. In humans, the scrotum becomes covered with pubic hair at puberty. The scrotum will usually tighten during penile erection and when exposed to cold temperatures. One testis is typically lower than the other to avoid compression in the event of an impact.
A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, oral sex, or sometimes manual sex. STIs often do not initially cause symptoms, which results in a risk of passing the infection on to others. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility.
Combinatio nova, abbreviated comb. nov., is Latin for "new combination". It is used in taxonomic biology literature when a new name is introduced based on a pre-existing name. The term should not be confused with species nova, used for a previously unnamed species.
Nasolacrimal duct obstruction is the obstruction of the nasolacrimal duct and may be either congenital or acquired. Obstruction of the nasolacrimal duct leads to the excess overflow of tears called epiphora.
Palpable purpura is characterized by firm, elevated hemorrhagic plaques or papules that can measure several centimeters in diameter. These are typically found on dependent surfaces, like the back of a recumbent patient or the lower legs. The center of a lesion may become ulcerative, pustular, vesicular, necrotic, or nodular. They tend to be asymptomatic, but when nodular or ulcerative, they can become tender. Palpable purpura is the most common cutaneous lesion among individuals with inflammatory vascular injury, whereas nonpalpable purpura typically indicates bleeding caused by a platelet or coagulation disorder.