Rickettsia conorii

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Rickettsia conorii
Rickettsia conorii in Vero.gif
Rickettsia conorii observed in Vero cells (red rods; magnification ×1,000) [1]
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species group: Spotted fever group
Species:
R. conorii
Binomial name
Rickettsia conorii
Brumpt 1932 [2]

Rickettsia conorii is a Gram-negative, obligate intracellular bacterium of the genus Rickettsia that causes human disease called boutonneuse fever, Mediterranean spotted fever, Israeli tick typhus, Astrakhan spotted fever, Kenya tick typhus, Indian tick typhus, or other names that designate the locality of occurrence while having distinct clinical features. [3] [4] It is a member of the spotted fever group and the most geographically dispersed species in the group, recognized in most of the regions bordering on the Mediterranean Sea and Black Sea, Israel, Kenya, and other parts of North, Central, and South Africa, and India. [3] The prevailing vector is the brown dog tick, Rhipicephalus sanguineus . The bacterium was isolated by Emile Brumpt in 1932 [5] and named after A. Conor, who in collaboration with A. Bruch, provided the first description of boutonneuse fever in Tunisia in 1910. [6]

The genome of the bacterium has been sequenced and four subspecies have been identified. [7] [8] [9] [10] [11]

Genomes of intracellular or parasitic bacteria undergo massive reduction compared to their free-living relatives. Examples include Rickettsia for alpha proteobacteria, T. whipplei for Actinobacteria, Mycoplasma for Firmicutes (the low G+C content Gram-positive), and Wigglesworthia and Buchnera for gamma proteobacteria. [12]

Some of the largest virions like Megavirus chilensis, Pandoravirus, Pithovirus and mimivirus are comparable in size to miniature bacteria like T. whipplei and Rickettsia conorii.

Related Research Articles

<i>Rickettsia</i> Genus of bacteria

Rickettsia is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci, bacilli, or threads. The term "rickettsia" has nothing to do with rickets ; the bacterial genus Rickettsia instead was named after Howard Taylor Ricketts, in honor of his pioneering work on tick-borne spotted fever.

<span class="mw-page-title-main">Boutonneuse fever</span> Medical condition

Boutonneuse fever is a fever as a result of a rickettsial infection caused by the bacterium Rickettsia conorii and transmitted by the dog tick Rhipicephalus sanguineus. Boutonneuse fever can be seen in many places around the world, although it is endemic in countries surrounding the Mediterranean Sea. This disease was first described in Tunisia in 1910 by Conor and Bruch and was named boutonneuse due to its papular skin-rash characteristics.

Mediterranean fever may refer to:

<i>Rickettsia rickettsii</i> Species of bacterium

Rickettsia rickettsii is a Gram-negative, intracellular, coccobacillus bacterium that is around 0.8 to 2.0 μm long. R. rickettsii is the causative agent of Rocky Mountain spotted fever. R. rickettsii is one of the most pathogenic Rickettsia strains. It affects a large majority of the Western Hemisphere and small portions of the Eastern Hemisphere.

A rickettsiosis is a disease caused by intracellular bacteria.

Bartonella quintana, originally known as Rochalimaea quintana, and "Rickettsia quintana", is a bacterium transmitted by the human body louse that causes trench fever. This bacterial species caused outbreaks of trench fever affecting 1 million soldiers in Europe during World War I.

<i>Orientia tsutsugamushi</i> Species of bacterium

Orientia tsutsugamushi is a mite-borne bacterium belonging to the family Rickettsiaceae and is responsible for a disease called scrub typhus in humans. It is a natural and an obligate intracellular parasite of mites belonging to the family Trombiculidae. With a genome of only 2.0–2.7 Mb, it has the most repeated DNA sequences among bacterial genomes sequenced so far. The disease, scrub typhus, occurs when infected mite larvae accidentally bite humans. Primarily indicated by undifferentiated febrile illnesses, the infection can be complicated and often fatal.

<i>Rhipicephalus sanguineus</i> Species of species of tick found worldwide

Rhipicephalus sanguineus, commonly called the brown dog tick, kennel tick, or pantropical dog tick, is a species of tick found worldwide, but more commonly in warmer climates. This species is unusual among ticks in that its entire lifecycle can be completed indoors. The brown dog tick is easily recognized by its reddish-brown color, elongated body shape, and hexagonal basis capituli. Adults are 2.28 to 3.18 mm in length and 1.11 to 1.68 mm in width. They do not have ornamentation on their backs.

<span class="mw-page-title-main">African tick bite fever</span> Medical condition

African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may include fever, headache, muscle pain, and a rash. At the site of the bite there is typically a red skin sore with a dark center. The onset of symptoms usually occurs 4–10 days after the bite. Complications are rare but may include joint inflammation. Some people do not develop symptoms.

Rickettsia australis is a bacterium that causes a medical condition called Queensland tick typhus. The probable vectors are the tick species, Ixodes holocyclus and Ixodes tasmani. Small marsupials are suspected reservoirs of this bacterium.

North Asian tick typhus also known as Siberian tick typhus, is a condition characterized by a maculopapular rash.

Rickettsia helvetica, previously known as the Swiss agent, is a bacterium found in Dermacentor reticulatus and other ticks, which has been implicated as a suspected but unconfirmed human pathogen. First recognized in 1979 in Ixodes ricinus ticks in Switzerland as a new member of the spotted fever group of Rickettsia, the R. helvetica bacterium was eventually isolated in 1993. Although R. helvetica was initially thought to be harmless in humans and many animal species, some individual case reports suggest that it may be capable of causing a nonspecific fever in humans. In 1997, a man living in eastern France seroconverted to Rickettsia 4 weeks after onset of an unexplained febrile illness. In 2010, a case report indicated that tick-borne R. helvetica can also cause meningitis in humans.

Rickettsia felis is a species of bacterium, the pathogen that causes cat-flea typhus in humans, also known as flea-borne spotted fever. Rickettsia felis also is regarded as the causative organism of many cases of illnesses generally classed as fevers of unknown origin in humans in Africa.

Rickettsia honei is a species of Rickettsia.

<i>Rickettsia sibirica</i> Species of bacterium

Rickettsia sibirica is a species of Rickettsia. This bacterium is the etiologic agent of North Asian tick typhus, which is also known as Siberian tick typhus. The ticks that transmit it are primarily various species of Dermacentor and Haemaphysalis.

Rickettsia japonica is a species of Rickettsia. It can cause Japanese spotted fever.

Rickettsia heilongjiangensis is a species of gram negative Alphaproteobacteria, within the spotted fever group, being carried by ticks. It is pathogenic.

Rickettsia massiliae is a tick-borne pathogenic spotted fever group Rickettsia species.

"Tropheryma whipplei" is a bacterium that is the causative organism of Whipple's disease, and rarely, endocarditis.

References

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  2. Skerman, VBD; McGowan, V; Sneath, PHA, eds. (1989). Approved Lists of Bacterial Names (amended ed.). Washington, DC: American Society for Microbiology.
  3. 1 2 Yu, XJ; Walker, DH (2005). "Genus I. Rickettsia da Rocha-Lima 1916, 567AL". In Brenner, DJ; Krieg, NR; Staley, JT; et al. (eds.). Bergey's Manual of Systematic Bacteriology, Volume 2, Part C (2nd ed.). New York: Springer. doi:10.1007/0-387-29298-5_28.
  4. Parola, P; Paddock, CD; Raoult, D (2005). "Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts". Clin Microbiol Rev. 18 (4): 719–756. doi:10.1128/CMR.18.4.719-756.2005. PMC   1265907 . PMID   16223955.
  5. Brumpt, E (1932). "Longevité du virus de la fièvre boutonneuse (Rickettsia conorii, n. sp.) chez la tique Rhipicephalus sanguineus". C. R. Soc. Biol. 110: 1119–1202.
  6. Conor, A & A Bruch (1910). "Une fièvre éruptive observée en Tunisie". Bull Soc Pathol Exot Filial. 8: 492–496.
  7. Zhu Y, Fournier PE, Eremeeva M, Raoult D (2005). "Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii". BMC Microbiol. 5: 11. doi:10.1186/1471-2180-5-11. PMC   1079849 . PMID   15766388.
  8. Ogata H, Audic S, Renesto-Audiffren P, et al. (September 2001). "Mechanisms of evolution in Rickettsia conorii and R. prowazekii". Science. 293 (5537): 2093–8. Bibcode:2001Sci...293.2093O. doi:10.1126/science.1061471. PMID   11557893. S2CID   35985908.
  9. Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (June 2012). "Genome sequence of Rickettsia conorii subsp. indica, the agent of Indian tick typhus". J. Bacteriol. 194 (12): 3288–9. doi:10.1128/JB.00462-12. PMC   3370856 . PMID   22628514.
  10. Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (September 2012). "Genome sequence of Rickettsia conorii subsp. caspia, the agent of Astrakhan fever". J. Bacteriol. 194 (17): 4763–4. doi:10.1128/JB.00992-12. PMC   3415478 . PMID   22887666.
  11. Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (September 2012). "Genome sequence of Rickettsia conorii subsp. israelensis, the agent of Israeli spotted fever". J. Bacteriol. 194 (18): 5130–1. doi:10.1128/JB.01118-12. PMC   3430316 . PMID   22933760.
  12. Raoult, Didier; Ogata, Hiroyuki; Audic, Stéphane; Robert, Catherine; Suhre, Karsten; Drancourt, Michel; Claverie, Jean-Michel (2003). "Tropheryma whipplei Twist: A Human Pathogenic Actinobacteria with a Reduced Genome". Genome Research. 13 (8): 1800–1809. doi:10.1101/gr.1474603. PMC   403771 . PMID   12902375.

Further reading