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Fever or pyrexia in humans is a body temperature above the normal range due to an increase in the body's temperature set point in the hypothalamus. There is no single agreed-upon upper limit for normal temperature: sources use values ranging between 37.2 and 38.3 °C in humans. The increase in set point triggers increased muscle contractions and causes a feeling of cold or chills. This results in greater heat production and efforts to conserve heat. When the set point temperature returns to normal, a person feels hot, becomes flushed, and may begin to sweat. Rarely a fever may trigger a febrile seizure, with this being more common in young children. Fevers do not typically go higher than 41 to 42 °C.
Rickettsia is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci, bacilli, or threads. The genus was named after Howard Taylor Ricketts in honor of his pioneering work on tick-borne spotted fever.
Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a fever and headache, which is followed a few days later with the development of a rash. The rash is generally made up of small spots of bleeding and starts on the wrists and ankles. Other symptoms may include muscle pains and vomiting. Long-term complications following recovery may include hearing loss or loss of part of an arm or leg.
Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and occasionally a characteristic non-itchy rash known as erythema marginatum. The heart is involved in about half of the cases. Damage to the heart valves, known as rheumatic heart disease (RHD), usually occurs after repeated attacks but can sometimes occur after one. The damaged valves may result in heart failure, atrial fibrillation and infection of the valves.
The spotted hyena, also known as the laughing hyena, is a hyena species, currently classed as the sole extant member of the genus Crocuta, native to sub-Saharan Africa. It is listed as being of least concern by the IUCN due to its widespread range and large numbers estimated between 27,000 and 47,000 individuals. The species is, however, experiencing declines outside of protected areas due to habitat loss and poaching. Populations of Crocuta, usually considered a subspecies of Crocuta crocuta, known as cave hyenas, roamed across Eurasia for at least one million years until the end of the Late Pleistocene. The spotted hyena is the largest extant member of the Hyaenidae, and is further physically distinguished from other species by its vaguely bear-like build, rounded ears, less prominent mane, spotted pelt, more dual-purposed dentition, fewer nipples, and pseudo-penis. It is the only placental mammalian species where females have a pseudo-penis and lack an external vaginal opening.
Rickettsia rickettsii is a Gram-negative, intracellular, coccobacillus bacterium that was first discovered in 1902. Having a reduced genome, the bacterium harvests nutrients from its host cell to carry out respiration, making it an organoheterotroph. Maintenance of its genome is carried out through vertical gene transfer where specialization of the bacterium allows it to shuttle host sugars directly into its TCA cycle.
A petechia is a small red or purple spot that can appear on the skin, conjunctiva, retina, and mucous membranes which is caused by haemorrhage of capillaries. The word is derived from Italian petecchia, 'freckle,' of obscure origin. It refers to one of the three descriptive types of hematoma differentiated by size, the other two being ecchymosis and purpura. The term is typically used in the plural (petechiae), since a single petechia is seldom noticed or significant.
Rickettsialpox is a mite-borne infectious illness caused by bacteria of the genus Rickettsia. Physician Robert Huebner and self-trained entomologist Charles Pomerantz played major roles in identifying the cause of the disease after an outbreak in 1946 in a New York City apartment complex, documented in "The Alerting of Mr. Pomerantz," an article by medical writer Berton Roueché.
Chemical, biological (CB) — and sometimes radiological — warfare agents were assigned what is termed a military symbol by the U.S. military until the American chemical and biological weapons programs were terminated. Military symbols applied to the CB agent fill, and not to the entire weapon. A chemical or biological weapon designation would be, for example, "Aero-14/B", which could be filled with GB, VX, TGB, or with a biological modification kit – OU, NU, UL, etc. A CB weapon is an integrated device of (1) agent, (2) dissemination means, and (3) delivery system.
Erwin Oskar Ding-Schuler was a German surgeon and an officer in the Waffen-SS who attained the rank of Sturmbannführer (Major). He is notable for having performed experiments on inmates of the Buchenwald concentration camp.
African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may include fever, headache, muscle pain, and a rash. At the site of the bite there is typically a red skin sore with a dark center. The onset of symptoms usually occurs 4–10 days after the bite. Complications are rare but may include joint inflammation. Some people do not develop symptoms.
Queensland tick typhus is a zoonotic disease caused by the bacterium Rickettsia australis. It is transmitted by the ticks Ixodes holocyclus and Ixodes tasmani.
Rickettsia australis is a bacterium that causes a medical condition called Queensland tick typhus. The probable vectors are the tick species, Ixodes holocyclus and Ixodes tasmani. Small marsupials are suspected reservoirs of this bacterium.
North Asian tick typhus also known as Siberian tick typhus, is a condition characterized by a maculopapular rash.
Flinders Island spotted fever is a condition characterized by a rash in approximately 85% of cases.
Japanese spotted fever is a condition characterized by a rash that has early macules, and later, in some patients, petechiae.
Rickettsia aeschlimannii infection is a condition characterized by a rash of maculopapules.
Rickettsia felis is a species of bacterium, the pathogen that causes cat-flea typhus in humans, also known as flea-borne spotted fever. Rickettsia felis also is regarded as the causative organism of many cases of illnesses generally classed as fevers of unknown origin in humans in Africa.
Paul Fiset was a Canadian-American microbiologist and virologist. His research helped to develop one of the first successful Q fever vaccines, noted by The New York Times. Fiset was born in Quebec, Canada, and attended Laval University, where he earned a Doctor of Medicine degree in 1949. He subsequently attended Cambridge University, where he received a PhD degree in 1956. As a professor at the University of Maryland School of Medicine, he also researched other bacterial diseases such as typhus and Rocky Mountain spotted fever, in addition to Q fever.
References
- ↑ Gideon Guide to Outbreaks: 2019 edition , p. 1522, at Google Books
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ↑ Didier Raoult; Philippe Parola (2007). Rickettsial diseases. CRC Press. pp. 87–. ISBN 978-0-8493-7611-5 . Retrieved 23 May 2010.