Clofuperol

Last updated
Clofluperol
Clofluperol.svg
Clinical data
Other namesSeperidol, R9298
Identifiers
  • 4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H22ClF4NO2
Molar mass 443.87 g·mol−1
3D model (JSmol)
  • C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
  • InChI=1S/C22H22ClF4NO2/c23-19-8-5-16(14-18(19)22(25,26)27)21(30)9-12-28(13-10-21)11-1-2-20(29)15-3-6-17(24)7-4-15/h3-8,14,30H,1-2,9-13H2
  • Key:LZFSKNPPWIFMFL-UHFFFAOYSA-N

Clofluperol is a neuroleptic tranquilizer of the butyrophenone class. It has the same aromatic piperidinol moiety that is present in penfluridol and fluperamide. The structure can be seen to be a sort of hybrid between that of trifluperidol and haloperidol.

Like penfluridol, clofuperol seems to share the property that it is a long-acting antipsychotic. [1]

Patent: [2] Pharmacology: [3] [4] Mass spectroscopy: [5]

References

  1. ↑ Bobon J, Pinchard A, Goffioul F, Devroye A, Bobon DP, Korn M. Neuroleptiques à longue durée d'action. I. Etude pilote du clofluperol (R9298) [Long-acting neuroleptics. I. Pilot study of clofluperol (R9298)]. Acta Neurol Psychiatr Belg. 1968 Feb;68(2):128-36. French. PMID 4972601.
  2. ↑ GB1141664 idem Paul Adriaan Jan Janssen, US3518276 (1970 to Janssen Pharmaceutica Nv).
  3. ↑ Janssen PA, Allewijn FT. The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity. Arzneimittelforschung. 1969 Feb;19(2):199-208. PMID 5818759.
  4. ↑ Mishkinsky J, Khazen K, Givant Y, Dikstein S. Sulman FG: Mammotropic and neuroleptic effects of butyrophenones in the rat. Arch Int Pharmacodyn Ther. 1969 May;179(1):94-105. PMID 5388566.
  5. ↑ Blessington, 8., Org. Mass. Spectrom., 1971, 5, 1113.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.