(S)-corytuberine synthase

(S)-corytuberine synthase
Identifiers
Organism	Coptis japonica
Symbol	CYP80G2
Alt. symbols	Corytuberine synthase
UniProt	A8CDR5
Other data
EC number	1.14.19.51
Search for Structures Swiss-model Domains InterPro

(S)-corytuberine synthase is a cytochrome P450 enzyme purified from the plant Coptis japonica (Japanese goldthread), ^[1] with EC number EC 1.14.19.51 and CYP Symbol CYP80G2 (Cytochrome P450, family 80, member G2), and catalyses an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis. ^[2]

References

1. Ikezawa N, Iwasa K, Sato F (April 2008). "Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells". The Journal of Biological Chemistry. 283 (14): 8810–21. Bibcode:2008JBiCh.283.8810I. doi: 10.1074/jbc.M705082200 . PMID   18230623.
2. Meelaph T, Kobtrakul K, Chansilpa NN, Han Y, Rani D, De-Eknamkul W, Vimolmangkang S (August 2018). "Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine". ACS Omega. 3 (8): 8794–8802. doi: 10.1021/acsomega.8b00827 . PMC   6644620 . PMID   31459012.