This is a list of television programs once broadcast by the American television network ABC that have ended their runs on the network.
| Title | Premiere date | Finale | Notes | Seasons |
|---|---|---|---|---|
| 12 O'Clock High | September 18, 1964 | January 13, 1967 | 3 | |
| 240-Robert | August 28, 1979 | March 21, 1981 | 2 | |
| 666 Park Avenue | September 30, 2012 | July 13, 2013 | 1 | |
| 77 Sunset Strip | October 10, 1958 | February 7, 1964 | 6 | |
| A Man Called Shenandoah | September 13, 1965 | May 16, 1966 | 1 | |
| Adventures in Paradise | October 5, 1959 | April 1, 1962 | 3 | |
| Alaska Daily | October 6, 2022 | March 30, 2023 | 1 | |
| The Alaskans | October 4, 1959 | June 19, 1960 | 1 | |
| Alias | September 30, 2001 | May 22, 2006 | 5 | |
| Alias Smith and Jones | January 5, 1971 | January 13, 1973 | 3 | |
| American Crime | March 5, 2015 | April 30, 2017 | 3 | |
| The Asphalt Jungle | April 2, 1961 | June 25, 1961 | 1 | |
| Automan | December 15, 1983 | April 2, 1984 | 1 | |
| The Avengers | October 2, 1966 | April 21, 1969 | Seasons 4–6 only; seasons 1–3 only aired on ITV. | 3 |
| B.A.D. Cats | January 4, 1980 | November 15, 1980 | 1 | |
| B.L. Stryker | February 13, 1989 | May 5, 1990 | 1 | |
| The Baker and the Beauty | April 13, 2020 | June 1, 2020 | 1 | |
| Barbary Coast | May 4, 1975 | January 9, 1976 | 1 | |
| Baretta | January 17, 1975 | May 18, 1978 | 4 | |
| Batman | January 12, 1966 | March 14, 1968 | 3 | |
| Battlestar Galactica | September 17, 1978 | April 29, 1979 | 1 | |
| Ben Casey | October 2, 1961 | March 21, 1966 | 5 | |
| Bert D'Angelo/Superstar | February 21, 1976 | July 10, 1976 | 1 | |
| Betrayal | September 29, 2013 | January 19, 2014 | 1 | |
| Big Shots | September 27, 2007 | January 24, 2008 | 1 | |
| Big Sky | November 17, 2020 | January 18, 2023 | 3 | |
| The Big Valley | September 15, 1965 | May 19, 1969 | 4 | |
| The Bionic Woman | January 14, 1976 | May 4, 1977 | Seasons 1–2 only; moved to NBC for season 3. | 2 |
| Birdland | January 5, 1994 | April 21, 1994 | 1 | |
| Black Box | April 24, 2014 | July 24, 2014 | 1 | |
| Blind Justice | March 8, 2005 | June 21, 2005 | 1 | |
| Blood & Oil | September 27, 2015 | December 13, 2015 | 1 | |
| Blue Light | January 12, 1966 | May 18, 1966 | 1 | |
| Blue Thunder | January 6, 1984 | April 16, 1984 | 1 | |
| Body of Proof | March 29, 2011 | May 28, 2013 | 3 | |
| Boston Legal | October 3, 2004 | December 8, 2008 | 5 | |
| Bourbon Street Beat | October 5, 1959 | July 4, 1960 | 1 | |
| Bronco | September 23, 1958 | April 30, 1962 | 4 | |
| Brothers & Sisters | September 24, 2006 | May 8, 2011 | 5 | |
| Buck James | September 27, 1987 | May 5, 1988 | 1 | |
| Burke's Law | September 20, 1963 | January 12, 1966 | 3 | |
| Bus Stop | October 1, 1961 | March 25, 1962 | 1 | |
| The Byrds of Paradise | March 3, 1994 | June 23, 1994 | 1 | |
| C-16: FBI | September 27, 1997 | July 2, 1998 | 1 | |
| Call to Glory | August 13, 1984 | June 30, 1985 | 1 | |
| Capital News | April 9, 1990 | April 30, 1990 | 1 | |
| Caribe | February 17, 1975 | May 12, 1975 | 1 | |
| Casablanca | September 27, 1955 | April 24, 1956 | 1 | |
| Cashmere Mafia | January 6, 2008 | February 20, 2008 | 1 | |
| Castle | March 9, 2009 | May 16, 2016 | 8 | |
| The Catch | March 24, 2016 | May 11, 2017 | 2 | |
| Charlie Grace | September 14, 1995 | October 19, 1995 | 1 | |
| Charlie's Angels | September 22, 1976 | June 24, 1981 | 5 | |
| Charlie's Angels | September 22, 2011 | November 10, 2011 | 1 | |
| Cheyenne | September 20, 1955 | December 17, 1962 | 7 | |
| China Beach | April 27, 1988 | July 22, 1991 | 4 | |
| Chopper One | January 17, 1974 | April 11, 1974 | 1 | |
| Civil Wars | November 20, 1991 | March 2, 1993 | 2 | |
| Code Red | November 1, 1981 | September 12, 1982 | 1 | |
| The Colbys | November 20, 1985 | March 26, 1987 | 2 | |
| Colt .45 | October 18, 1957 | September 27, 1960 | 3 | |
| Columbo | February 6, 1989 | January 30, 2003 | Seasons 8–10 only; seasons 1–7 aired on NBC. | 3 |
| Combat! | October 2, 1962 | March 14, 1967 | 5 | |
| Combat Hospital | June 21, 2011 | September 6, 2011 | Co-production with Global. | 1 |
| Commander in Chief | September 27, 2005 | June 14, 2006 | 1 | |
| The Commish | September 28, 1991 | January 11, 1996 | 5 | |
| The Company You Keep | February 19, 2023 | May 7, 2023 | 1 | |
| Conviction | October 3, 2016 | January 29, 2017 | 1 | |
| Cop Rock | September 26, 1990 | December 26, 1990 | 1 | |
| The Court | March 26, 2002 | April 9, 2002 | 1 | |
| Court Martial | January 8, 1966 | September 2, 1966 | Originally aired on ITV. | 1 |
| Covington Cross | August 25, 1992 | October 31, 1992 | 1 | |
| The Cowboys | February 6, 1974 | June 27, 1974 | 1 | |
| Cracker | September 18, 1997 | January 24, 1998 | 1 | |
| Crime with Father | August 31, 1951 | January 18, 1952 | 1 | |
| The Crossing | April 2, 2018 | June 9, 2018 | 1 | |
| Crossroads | September 14, 1992 | July 15, 1993 | 1 | |
| Cupid | September 26, 1998 | February 11, 1999 | 1 | |
| Cupid | March 31, 2009 | June 16, 2009 | 1 | |
| Custer | September 6, 1967 | December 27, 1967 | 1 | |
| Dan August | September 23, 1970 | April 8, 1971 | 1 | |
| The Dakotas | January 7, 1963 | May 13, 1963 | 1 | |
| Dangerous Minds | September 30, 1996 | March 15, 1997 | 1 | |
| Darkroom | November 27, 1981 | January 15, 1982 | 1 | |
| Day Break | November 15, 2006 | December 13, 2006 | 1 | |
| The Days | July 18, 2004 | August 22, 2004 | 1 | |
| Deception | March 11, 2018 | May 27, 2018 | 1 | |
| The Deep End | January 21, 2010 | February 25, 2010 | 1 | |
| Defying Gravity | August 2, 2009 | October 23, 2009 | 1 | |
| Designated Survivor | September 21, 2016 | May 16, 2018 | Seasons 1–2 only; moved to Netflix for season 3. | 2 |
| Desperate Housewives | October 3, 2004 | May 13, 2012 | 8 | |
| Detroit 1-8-7 | September 21, 2010 | March 20, 2011 | 1 | |
| Dirty Sexy Money | September 26, 2007 | August 8, 2009 | 2 | |
| Doc Elliot | October 10, 1973 | May 1, 1974 | 1 | |
| Doogie Howser, M.D. | September 19, 1989 | March 24, 1993 | 4 | |
| Dynasty | January 12, 1981 | May 11, 1989 | 9 | |
| Eastwick | September 23, 2009 | December 30, 2009 | 1 | |
| Eight Is Enough | March 15, 1977 | May 23, 1981 | 5 | |
| Eli Stone | January 31, 2008 | July 11, 2009 | 2 | |
| Elvis | February 6, 1990 | May 19, 1990 | 1 | |
| Emergence | September 24, 2019 | January 28, 2020 | 1 | |
| Equal Justice | March 27, 1990 | July 3, 1991 | 2 | |
| The Evidence | March 22, 2006 | July 1, 2006 | 1 | |
| Eyes | March 30, 2005 | April 27, 2005 | 1 | |
| The F.B.I. | September 19, 1965 | April 28, 1974 | 9 | |
| The Fall Guy | November 4, 1981 | May 2, 1986 | 5 | |
| Family | March 9, 1976 | June 25, 1980 | 5 | |
| The Family | March 3, 2016 | May 15, 2016 | 1 | |
| Fantasy Island | January 14, 1977 | May 19, 1984 | 7 | |
| Fantasy Island | September 26, 1998 | January 23, 1999 | 1 | |
| FBI: The Untold Stories | September 26, 1991 | June 1, 1993 | 2 | |
| The Feather & Father Gang | December 6, 1976 | July 30, 1977 | 1 | |
| The Felony Squad | September 12, 1966 | January 31, 1969 | 3 | |
| Finder of Lost Loves | September 22, 1984 | April 13, 1985 | 1 | |
| A Fine Romance | January 18, 1989 | March 2, 1989 | 1 | |
| Firehouse | January 17, 1974 | April 11, 1974 | 1 | |
| The Fix | March 18, 2019 | May 20, 2019 | 1 | |
| FlashForward | September 24, 2009 | May 27, 2010 | 1 | |
| Follow the Sun | September 17, 1961 | April 8, 1962 | 1 | |
| For Life | February 11, 2020 | February 24, 2021 | 2 | |
| For the People | March 13, 2018 | May 16, 2019 | 2 | |
| Forever | September 22, 2014 | May 5, 2015 | 1 | |
| The Forgotten | September 22, 2009 | July 3, 2010 | 1 | |
| The Fugitive | September 17, 1963 | August 29, 1967 | 4 | |
| Gabriel's Fire | September 12, 1990 | June 6, 1991 | 1 | |
| Galactica 1980 | January 27, 1980 | May 4, 1980 | 1 | |
| The Gallant Men | October 5, 1962 | March 30, 1963 | 1 | |
| The Gates | June 20, 2010 | September 19, 2010 | 1 | |
| GCB | March 4, 2012 | May 6, 2012 | 1 | |
| G.E. Summer Originals | July 3, 1956 | September 18, 1956 | 1 | |
| Get Christie Love! | January 22, 1974 | April 5, 1975 | 1 | |
| Gideon's Crossing | October 10, 2000 | April 16, 2001 | 1 | |
| Glitter | September 13, 1984 | December 25, 1984 | 1 | |
| Going to Extremes | September 1, 1992 | January 27, 1993 | 1 | |
| The Good Doctor | September 25, 2017 | May 21, 2024 | 7 | |
| Grand Hotel | June 17, 2019 | September 9, 2019 | 1 | |
| The Greatest American Hero | March 18, 1981 | February 3, 1983 | 3 | |
| The Green Hornet | September 9, 1966 | March 17, 1967 | 1 | |
| Griff | January 4, 1974 | February 3, 1983 | 1 | |
| Gun | April 12, 1997 | May 31, 1997 | 1 | |
| The Guns of Will Sonnett | September 8, 1967 | September 16, 1969 | 2 | |
| Happy Town | April 28, 2010 | July 1, 2010 | First 6 episodes only; the remaining 2 episodes only aired on ABC.com. | 1 |
| Hardcastle and McCormick | September 18, 1983 | May 5, 1986 | 3 | |
| The Hardy Boys/Nancy Drew Mysteries | January 30, 1977 | January 14, 1979 | 3 | |
| Hart to Hart | August 25, 1979 | May 22, 1984 | 5 | |
| Hawaiian Eye | October 7, 1959 | April 2, 1963 | 4 | |
| Hawaiian Heat | September 14, 1984 | December 21, 1984 | 1 | |
| Heart of the City | September 20, 1986 | January 10, 1987 | 1 | |
| High Incident | March 4, 1996 | May 8, 1997 | 2 | |
| Hollywood Beat | September 21, 1985 | November 23, 1985 | 1 | |
| Homefront | September 24, 1991 | April 26, 1993 | 2 | |
| Honey West | September 17, 1965 | April 8, 1966 | 1 | |
| Hong Kong | September 28, 1960 | March 29, 1961 | 1 | |
| Hooperman | September 23, 1987 | July 19, 1989 | 2 | |
| Hotel | September 21, 1983 | May 5, 1988 | 5 | |
| Hothouse | June 30, 1988 | August 25, 1988 | 1 | |
| How the West Was Won | January 19, 1976 | April 23, 1979 | 3 | |
| How to Get Away with Murder | September 25, 2014 | May 14, 2020 | 6 | |
| Human Target | July 20, 1992 | August 29, 1992 | 1 | |
| The Immortal | September 24, 1970 | January 14, 1971 | 1 | |
| In Justice | January 1, 2006 | March 31, 2006 | 1 | |
| The Insiders | September 25, 1985 | June 2, 1986 | 1 | |
| The Invaders | January 10, 1967 | March 26, 1968 | 2 | |
| Invasion | September 21, 2005 | May 17, 2006 | 1 | |
| Iron Horse | September 12, 1966 | January 6, 1968 | 2 | |
| It Takes a Thief | January 9, 1968 | March 24, 1970 | 3 | |
| Jack and Mike | September 16, 1986 | March 24, 1987 | 1 | |
| Jack's Place | May 26, 1992 | July 13, 1993 | 2 | |
| Karen Sisco | October 1, 2003 | December 3, 2003 | 1 | |
| Kevin (Probably) Saves the World | October 3, 2017 | March 6, 2018 | 1 | |
| Killer Women | January 7, 2014 | March 25, 2014 | 1 | |
| Kingdom Hospital | March 3, 2004 | July 15, 2004 | 1 | |
| King's Crossing | January 16, 1982 | February 27, 1982 | 1 | |
| Kings Row | September 13, 1955 | January 17, 1956 | 1 | |
| Knightwatch | November 10, 1988 | January 19, 1989 | 1 | |
| Kolchak: The Night Stalker | September 13, 1974 | March 28, 1975 | 1 | |
| Kung Fu | October 14, 1972 | April 26, 1975 | 3 | |
| L.A. Dragnet | February 2, 2003 | May 5, 2004 | 2 | |
| Lady Blue | April 15, 1985 | January 25, 1986 | 1 | |
| Land of the Giants | September 22, 1968 | March 22, 1970 | 2 | |
| Lash of the West | January 4, 1953 | April 26, 1953 | 1 | |
| Last Resort | September 27, 2012 | January 24, 2013 | 1 | |
| Lawman | October 5, 1958 | June 24, 1962 | 4 | |
| The Legend of Jesse James | September 13, 1965 | May 9, 1966 | 1 | |
| Life as We Know It | October 7, 2004 | January 20, 2005 | 1 | |
| Life Goes On | September 12, 1989 | May 23, 1993 | 4 | |
| Life on Mars | October 9, 2008 | April 1, 2009 | 1 | |
| Line of Fire | December 2, 2003 | May 30, 2004 | 1 | |
| Lois & Clark: The New Adventures of Superman | September 12, 1993 | June 14, 1997 | 4 | |
| The Lone Ranger | September 15, 1949 | June 6, 1957 | 5 | |
| Lost | September 22, 2004 | May 23, 2010 | 6 | |
| Lottery! | September 9, 1983 | June 14, 1984 | 1 | |
| The Love Boat | September 24, 1977 | May 24, 1986 | 9 | |
| Lucan | September 12, 1977 | December 4, 1978 | 2 | |
| Lucky 7 | September 24, 2013 | October 1, 2013 | 1 | |
| MacGruder and Loud | January 20, 1985 | April 30, 1985 | 1 | |
| MacGyver | September 29, 1985 | May 21, 1992 | 7 | |
| Marcus Welby, M.D. | September 23, 1969 | July 29, 1976 | 7 | |
| Marvel's Agent Carter | January 6, 2015 | March 1, 2016 | 2 | |
| Marvel's Agents of S.H.I.E.L.D. | September 24, 2013 | August 12, 2020 | 7 | |
| Marvel's Inhumans | September 29, 2017 | November 10, 2017 | 1 | |
| Masquerade | December 15, 1983 | April 27, 1984 | 1 | |
| Masters of Science Fiction | August 4, 2007 | August 25, 2007 | 1 | |
| Matlock | November 5, 1992 | May 7, 1995 | Seasons 7–9 only; seasons 1–6 aired on NBC. | 3 |
| Matt Helm | September 20, 1975 | January 3, 1976 | 1 | |
| Matt Houston | September 26, 1982 | July 19, 1985 | 3 | |
| Matt Lincoln | September 24, 1970 | January 14, 1971 | 1 | |
| Maverick | September 22, 1957 | April 22, 1962 | 5 | |
| Max Headroom | March 31, 1987 | May 5, 1988 | 2 | |
| McKenna | September 15, 1994 | July 20, 1995 | 1 | |
| MDs | September 25, 2002 | December 11, 2002 | 1 | |
| Men in Trees | September 12, 2006 | June 11, 2008 | 2 | |
| Me and Mom | April 15, 1985 | May 17, 1985 | 1 | |
| A Million Little Things | September 26, 2018 | May 3, 2023 | 5 | |
| Mind Games | February 25, 2014 | March 25, 2014 | 1 | |
| Miracles | January 27, 2003 | December 26, 2003 | 1 | |
| Missing | March 15, 2012 | May 17, 2012 | 1 | |
| Missing Persons | August 30, 1993 | February 17, 1994 | 1 | |
| Mission: Impossible | October 23, 1988 | February 24, 1990 | 2 | |
| Mistresses | June 3, 2013 | September 6, 2016 | 4 | |
| Mobile One | September 12, 1975 | January 5, 1976 | 1 | |
| The Mod Squad | September 24, 1968 | March 1, 1973 | 5 | |
| The Monroes | September 7, 1966 | March 15, 1967 | 1 | |
| Moonlighting | March 3, 1985 | May 14, 1989 | 5 | |
| Moon Over Miami | September 15, 1993 | December 1, 1993 | 1 | |
| The Most Deadly Game | October 10, 1970 | January 16, 1971 | 1 | |
| Most Wanted | October 16, 1976 | August 20, 1977 | 1 | |
| Motive | February 3, 2013 | May 29, 2014 | Seasons 1–2 only; moved to USA Network for seasons 3–4. | 2 |
| Murder One | September 19, 1995 | May 29, 1997 | 2 | |
| Murphy's Law | November 2, 1988 | March 18, 1989 | 1 | |
| My Generation | September 23, 2010 | September 30, 2010 | 1 | |
| My Life and Times | April 24, 1991 | May 30, 1991 | 1 | |
| My So-Called Life | August 25, 1994 | January 26, 1995 | 1 | |
| N.Y.P.D. | September 5, 1967 | March 25, 1969 | 2 | |
| Nakia | September 21, 1974 | December 28, 1974 | 1 | |
| Nashville | October 10, 2012 | May 25, 2016 | Seasons 1–4 only; moved to CMT for seasons 5–6. | 4 |
| The New Breed | October 3, 1961 | June 5, 1962 | 1 | |
| Night Stalker | September 29, 2005 | March 17, 2006 | 1 | |
| The Nine | October 4, 2006 | August 8, 2007 | 1 | |
| No Ordinary Family | September 28, 2010 | April 5, 2011 | 1 | |
| Nothing Sacred | September 18, 1997 | March 14, 1998 | 1 | |
| Notorious | September 22, 2016 | December 8, 2016 | 1 | |
| NYPD Blue | September 21, 1993 | March 1, 2005 | 12 | |
| October Road | March 15, 2007 | March 10, 2008 | 2 | |
| Of Kings and Prophets | March 8, 2016 | May 3, 2016 | 1 | |
| Off the Map | January 12, 2011 | April 6, 2011 | 1 | |
| Ohara | January 17, 1987 | May 7, 1988 | 2 | |
| Once a Hero | September 19, 1987 | October 3, 1987 | 1 | |
| Once and Again | September 21, 1999 | April 15, 2002 | 3 | |
| Once Upon a Time | October 23, 2011 | May 18, 2018 | 7 | |
| Once Upon a Time in Wonderland | October 10, 2013 | April 3, 2014 | 1 | |
| Our Family Honor | September 17, 1985 | January 3, 1986 | 1 | |
| The Outer Limits | September 16, 1963 | January 16, 1965 | 2 | |
| The Outcasts | September 23, 1968 | May 5, 1969 | 1 | |
| Owen Marshall, Counselor at Law | September 16, 1971 | August 24, 1974 | 3 | |
| Pan Am | September 25, 2011 | February 19, 2012 | 1 | |
| Paper Dolls | September 23, 1984 | December 25, 1984 | 1 | |
| The Persuaders! | September 18, 1971 | February 9, 1972 | 1 | |
| Peyton Place | September 15, 1964 | June 2, 1969 | 5 | |
| Philly | September 25, 2001 | May 28, 2002 | 1 | |
| The Phoenix | March 19, 1982 | April 16, 1982 | 1 | |
| The Practice | March 4, 1997 | May 16, 2004 | 8 | |
| Preview Tonight | August 14, 1966 | September 11, 1966 | 1 | |
| Private Practice | September 26, 2007 | January 22, 2013 | 6 | |
| Probe | March 7, 1988 | April 14, 1988 | 1 | |
| Promised Land | January 24, 2022 | March 29, 2022 | First 5 episodes only; the remaining 5 episodes only aired on Hulu. | 1 |
| Pros and Cons | September 26, 1991 | January 2, 1992 | 1 | |
| Push, Nevada | September 17, 2002 | October 24, 2002 | 1 | |
| Pushing Daisies | October 3, 2007 | June 13, 2009 | 2 | |
| Quantico | September 27, 2015 | August 3, 2018 | 3 | |
| Queens | October 19, 2021 | February 15, 2022 | 1 | |
| The Quest | October 22, 1982 | November 19, 1982 | 1 | |
| The Rat Patrol | September 12, 1966 | March 18, 1968 | 2 | |
| Rebel | April 8, 2021 | June 10, 2021 | 1 | |
| Red Widow | March 3, 2013 | May 5, 2013 | 1 | |
| Reef Break | June 20, 2019 | September 13, 2019 | Co-production with M6 | 1 |
| Relativity | September 24, 1996 | April 14, 1997 | 1 | |
| The Renegades | March 4, 1983 | April 8, 1983 | 1 | |
| Resurrection | March 9, 2014 | January 25, 2015 | 2 | |
| Revenge | September 21, 2011 | May 10, 2015 | 4 | |
| The Rifleman | September 30, 1958 | April 8, 1963 | 5 | |
| The River | February 7, 2012 | March 20, 2012 | 1 | |
| The Roaring 20's | October 15, 1960 | January 20, 1962 | 2 | |
| Rookie Blue | June 24, 2010 | July 29, 2015 | Co-production with Global | 6 |
| The Rookie: Feds | September 27, 2022 | May 2, 2023 | 1 | |
| The Rookies | March 7, 1972 | March 30, 1976 | 4 | |
| Room 222 | September 11, 1969 | January 11, 1974 | 5 | |
| S.W.A.T. | February 24, 1975 | April 3, 1976 | 2 | |
| Sable | November 7, 1987 | January 2, 1988 | 1 | |
| Scandal | April 5, 2012 | April 19, 2018 | 7 | |
| Scoundrels | June 20, 2010 | August 15, 2010 | 1 | |
| Second Noah | February 5, 1996 | June 8, 1997 | 2 | |
| Secrets and Lies | March 1, 2015 | December 4, 2016 | 2 | |
| Shadow Chasers | November 14, 1985 | January 16, 1986 | 1 | |
| Sidekicks | September 26, 1986 | June 13, 1987 | 1 | |
| Six Degrees | September 21, 2006 | March 30, 2007 | First 8 episodes only; the remaining 5 episodes only aired on ABC.com. | 1 |
| The Six Million Dollar Man | January 18, 1974 | March 6, 1978 | 5 | |
| The Sixth Sense | January 15, 1972 | December 23, 1972 | 2 | |
| Snoops | September 26, 1999 | December 19, 1999 | 1 | |
| Somewhere Between | July 24, 2017 | September 19, 2017 | 1 | |
| Spenser: For Hire | September 20, 1985 | May 7, 1988 | 3 | |
| Spy Game | March 3, 1997 | July 12, 1997 | 1 | |
| Stagecoach West | October 4, 1960 | June 27, 1961 | 1 | |
| Stand By for Crime | January 11, 1949 | August 27, 1949 | 1 | |
| Starman | September 19, 1986 | May 2, 1987 | 1 | |
| Starsky & Hutch | April 30, 1975 | May 15, 1979 | 4 | |
| Station 19 | March 22, 2018 | May 30, 2024 | 7 | |
| Still Star-Crossed | May 29, 2017 | July 29, 2017 | 1 | |
| Stone | January 14, 1980 | March 17, 1980 | 1 | |
| Straightaway | October 6, 1961 | April 4, 1962 | 1 | |
| Strange World | March 8, 1999 | March 16, 1999 | 1 | |
| The Strauss Family | November 7, 1972 | December 19, 1972 | Originally aired on ATV. | 1 |
| The Streets of San Francisco | September 16, 1972 | June 9, 1977 | 5 | |
| Strike Force | April 2, 1981 | May 21, 1982 | 1 | |
| Studio 5-B | January 24, 1989 | February 5, 1989 | 1 | |
| Stumptown | September 25, 2019 | March 25, 2020 | 1 | |
| Sugarfoot | September 17, 1957 | April 17, 1961 | 4 | |
| Supercarrier | March 6, 1988 | May 14, 1988 | 1 | |
| Surfside 6 | October 6, 1960 | June 25, 1962 | 2 | |
| The Swiss Family Robinson | September 14, 1975 | April 11, 1976 | 1 | |
| T. J. Hooker | March 13, 1982 | May 4, 1985 | Seasons 1–4 only; moved to CBS for season 5. | 4 |
| Take Two | June 21, 2018 | September 13, 2018 | 1 | |
| Tales of the Gold Monkey | September 22, 1982 | June 1, 1983 | 1 | |
| Tales of Tomorrow | August 3, 1951 | June 12, 1953 | 2 | |
| Ten Days in the Valley | October 1, 2017 | January 6, 2018 | 1 | |
| Tenspeed and Brown Shoe | January 27, 1980 | June 27, 1980 | 1 | |
| That Was Then | September 27, 2002 | October 4, 2002 | 1 | |
| Thirtysomething | September 29, 1987 | May 28, 1991 | 4 | |
| Threat Matrix | September 18, 2003 | January 29, 2004 | 1 | |
| Time After Time | March 5, 2017 | March 26, 2017 | 1 | |
| The Time Tunnel | September 9, 1966 | April 7, 1967 | 1 | |
| Timecop | September 22, 1997 | July 18, 1998 | 1 | |
| Today's FBI | October 25, 1981 | April 26, 1982 | 1 | |
| Toma | March 21, 1973 | May 10, 1974 | 1 | |
| Total Security | September 27, 1997 | November 8, 1997 | 1 | |
| Trauma Center | September 22, 1983 | December 8, 1983 | 1 | |
| Traveler | May 10, 2007 | July 18, 2007 | 1 | |
| Twin Peaks | April 8, 1990 | June 10, 1991 | Seasons 1–2 only; moved to Showtime for season 3. | 2 |
| Ugly Betty | September 28, 2006 | April 14, 2010 | 4 | |
| Under Cover | January 7, 1991 | July 20, 1991 | 1 | |
| The Untouchables | October 15, 1959 | May 21, 1963 | 4 | |
| The Unusuals | April 8, 2009 | June 17, 2009 | 1 | |
| V | November 3, 2009 | March 15, 2011 | 2 | |
| Vegas | September 20, 1978 | June 3, 1981 | 3 | |
| Vengeance Unlimited | September 29, 1998 | February 25, 1999 | 1 | |
| Veritas: The Quest | January 27, 2003 | June 24, 2003 | 1 | |
| Voyage to the Bottom of the Sea | September 14, 1964 | March 31, 1968 | 4 | |
| Wagon Train | September 18, 1957 | May 2, 1965 | 8 | |
| Wasteland | October 7, 1999 | October 21, 1999 | 1 | |
| What About Brian | April 16, 2006 | March 29, 2007 | 2 | |
| Whiskey Cavalier | February 24, 2019 | May 22, 2019 | 1 | |
| The Whispers | June 1, 2015 | August 31, 2015 | 1 | |
| The Whole Truth | September 22, 2010 | December 1, 2010 | 1 | |
| Wicked City | October 27, 2015 | December 15, 2015 | 1 | |
| Wildside | March 21, 1985 | April 25, 1985 | 1 | |
| Women's Murder Club | October 12, 2007 | May 13, 2008 | 1 | |
| Wonderland | March 30, 2000 | April 6, 2000 | 1 | |
| Wonder Woman | November 7, 1975 | February 16, 1977 | Season 1 only; moved to CBS for seasons 2–3. | 1 |
| The Wonder Years | January 31, 1988 | May 12, 1993 | 6 | |
| The Wonder Years (2021) | September 22, 2021 | August 16, 2023 | 2 | |
| The Young Indiana Jones Chronicles | March 4, 1992 | July 24, 1993 | 2 | |
| The Young Lawyers | September 21, 1970 | March 24, 1971 | 1 | |
| The Young Rebels | September 20, 1970 | January 3, 1971 | 1 | |
| The Young Riders | September 20, 1989 | July 23, 1992 | 3 | |
| Zero Hour | February 14, 2013 | August 3, 2013 | 1 | |
| Zorro | October 10, 1957 | July 2, 1959 | 2 |
| Title | Premiere date | Finale | Notes | Seasons |
|---|---|---|---|---|
| 8 Simple Rules | September 17, 2002 | April 15, 2005 | 3 | |
| 9 to 5 | March 25, 1982 | October 27, 1983 | 3 | |
| A.E.S. Hudson Street | March 16, 1978 | April 20, 1978 | 1 | |
| a.k.a. Pablo | March 6, 1984 | April 10, 1984 | 1 | |
| According to Jim | October 3, 2001 | June 2, 2009 | 8 | |
| Adam's Rib | September 14, 1973 | December 28, 1973 | 1 | |
| The Addams Family | September 18, 1964 | April 8, 1966 | 2 | |
| The Adventures of Ozzie and Harriet | October 3, 1952 | April 23, 1966 | 14 | |
| Alex, Inc. | March 28, 2018 | May 16, 2018 | 1 | |
| Aloha Paradise | February 25, 1981 | April 22, 1981 | 1 | |
| Amanda's | February 10, 1983 | May 26, 1983 | 1 | |
| American Housewife | October 11, 2016 | March 31, 2021 | 5 | |
| Angie | February 8, 1979 | September 4, 1980 | 2 | |
| Anything but Love | March 7, 1989 | June 3, 1992 | 4 | |
| Apple Pie | September 23, 1978 | September 30, 1978 | 1 | |
| Arresting Behavior | August 18, 1992 | September 2, 1992 | 1 | |
| Arsenio | March 5, 1997 | April 23, 1997 | 1 | |
| The Associates | September 23, 1979 | April 17, 1980 | 1 | |
| At Ease | March 4, 1983 | June 10, 1983 | 1 | |
| Baby Makes Five | April 1, 1983 | April 29, 1983 | 1 | |
| Baby Talk | March 8, 1991 | May 8, 1992 | 2 | |
| Back in the Game | September 25, 2013 | February 23, 2014 | 1 | |
| Barefoot in the Park | September 24, 1970 | December 17, 1970 | 1 | |
| Barney Miller | January 23, 1975 | May 20, 1982 | 8 | |
| Benson | September 13, 1979 | April 19, 1986 | 7 | |
| Best of the West | September 10, 1981 | August 23, 1982 | 1 | |
| Better Off Ted | March 18, 2009 | August 24, 2010 | 2 | |
| Better with You | September 22, 2010 | May 11, 2011 | 1 | |
| The Beulah Show | October 3, 1950 | September 22, 1953 | 3 | |
| Bewitched | September 17, 1964 | March 25, 1972 | 8 | |
| Big Day | November 28, 2006 | January 30, 2007 | 1 | |
| Billy | January 31, 1992 | May 30, 1992 | 1 | |
| Black-ish | September 24, 2014 | April 19, 2022 | 8 | |
| Blansky's Beauties | February 12, 1977 | June 27, 1977 | 1 | |
| Bless This Mess | April 16, 2019 | May 5, 2020 | 2 | |
| Blue Skies | September 12, 1994 | October 24, 1994 | 1 | |
| Bob & Carol & Ted & Alice | September 26, 1973 | November 7, 1973 | 1 | |
| Bob Patterson | October 2, 2001 | October 31, 2001 | 1 | |
| Bosom Buddies | November 27, 1980 | March 27, 1982 | 2 | |
| Boy Meets World | September 24, 1993 | May 5, 2000 | 7 | |
| The Brady Bunch | September 26, 1969 | March 8, 1974 | 5 | |
| Brother's Keeper | September 25, 1998 | May 14, 1999 | 1 | |
| Buddies | March 5, 1996 | April 3, 1996 | 1 | |
| Call Your Mother | January 13, 2021 | May 19, 2021 | 1 | |
| Camp Wilder | September 18, 1992 | February 26, 1993 | 1 | |
| Carpoolers | October 2, 2007 | March 4, 2008 | 1 | |
| Carter Country | September 15, 1977 | August 23, 1979 | 2 | |
| Cavemen | October 2, 2007 | November 13, 2007 | 1 | |
| The Charmings | March 20, 1987 | February 11, 1988 | 2 | |
| Chicken Soup | September 12, 1989 | November 7, 1989 | 1 | |
| Clueless | September 20, 1996 | February 14, 1997 | Season 1 only; moved to UPN for seasons 2–3. | 1 |
| Coach | February 28, 1989 | May 14, 1997 | 9 | |
| Common Law | September 28, 1996 | October 19, 1996 | 1 | |
| Complete Savages | September 24, 2004 | June 17, 2005 | 1 | |
| Condo | February 10, 1983 | June 9, 1983 | 1 | |
| Cougar Town | September 23, 2009 | May 29, 2012 | Seasons 1–3 only; moved to TBS for seasons 4–6. | 3 |
| The Courtship of Eddie's Father | September 17, 1969 | March 1, 1972 | 3 | |
| Cristela | October 10, 2014 | March 6, 2015 | 1 | |
| Crumbs | January 12, 2006 | February 7, 2006 | 1 | |
| Dads | December 5, 1986 | February 6, 1987 | 1 | |
| The Danny Thomas Show | September 29, 1953 | April 25, 1957 | Seasons 1–4 only; moved to CBS seasons 5–11. | 4 |
| Davis Rules | January 27, 1991 | April 9, 1991 | Season 1 only; moved to CBS for season 2. | 1 |
| Delta | September 15, 1992 | August 25, 1993 | 1 | |
| Delta House | January 18, 1979 | April 21, 1979 | 1 | |
| Detective School | July 31, 1979 | November 24, 1979 | 2 | |
| Dharma & Greg | September 24, 1997 | April 30, 2002 | 5 | |
| Diff'rent Strokes | September 27, 1985 | March 7, 1986 | Season 8 only; seasons 1–7 aired on NBC. | 1 |
| Dinosaurs | April 26, 1991 | October 19, 1994 | 4 | |
| Don't Trust the B---- in Apartment 23 | April 11, 2012 | September 6, 2014 | 2 | |
| The Donna Reed Show | September 24, 1958 | March 19, 1966 | 8 | |
| Downward Dog | May 17, 2017 | June 27, 2017 | 1 | |
| Dr. Ken | October 2, 2015 | March 31, 2017 | 2 | |
| The Drew Carey Show | September 13, 1995 | September 8, 2004 | 9 | |
| Ellen | March 29, 1994 | July 22, 1998 | 5 | |
| The Ellen Burstyn Show | September 20, 1986 | September 5, 1987 | 1 | |
| Emily's Reasons Why Not | January 9, 2006 | January 9, 2006 | Only one episode aired from this series that had six episodes produced. | 1 |
| F Troop | September 14, 1965 | April 6, 1967 | 2 | |
| Family Man | March 18, 1988 | April 29, 1988 | 1 | |
| Family Matters | September 22, 1989 | May 9, 1997 | Seasons 1–8 only; moved to CBS for season 9. | 8 |
| Family Tools | May 1, 2013 | July 10, 2013 | 1 | |
| The Farmer's Daughter | September 20, 1963 | April 22, 1966 | 3 | |
| Fish | February 5, 1977 | May 18, 1978 | 2 | |
| The Flying Nun | September 7, 1967 | April 3, 1970 | 3 | |
| Freddie | October 12, 2005 | May 31, 2006 | 1 | |
| Free Spirit | September 22, 1989 | January 14, 1990 | 1 | |
| Fresh Off the Boat | February 4, 2015 | February 21, 2020 | 6 | |
| Full House | September 22, 1987 | May 23, 1995 | 8 | |
| Galavant | January 4, 2015 | January 31, 2016 | 2 | |
| The Geena Davis Show | October 10, 2000 | July 10, 2001 | 1 | |
| George | November 5, 1993 | January 19, 1994 | 1 | |
| George Lopez | March 27, 2002 | May 8, 2007 | 6 | |
| Getting By | March 5, 1993 | May 21, 1993 | Season 1 only; moved to NBC for season 2. | 1 |
| Getting Together | September 18, 1971 | January 8, 1972 | 1 | |
| The Ghost & Mrs. Muir | September 18, 1969 | March 13, 1970 | Season 2 only; season 1 aired on NBC. | 1 |
| Gidget | September 15, 1965 | April 21, 1966 | 1 | |
| Going Places | September 21, 1990 | March 8, 1991 | 1 | |
| The Goldbergs | September 23, 2013 | May 3, 2023 | 10 | |
| Good & Evil | September 25, 1991 | October 30, 1991 | 1 | |
| Good Heavens | February 29, 1976 | June 26, 1976 | 1 | |
| Grace Under Fire | September 29, 1993 | February 17, 1998 | 5 | |
| Growing Pains | September 24, 1985 | April 25, 1992 | 7 | |
| Hail to the Chief | April 9, 1985 | May 21, 1985 | 1 | |
| Hangin' with Mr. Cooper | September 22, 1992 | August 30, 1997 | 5 | |
| Hank | September 30, 2009 | November 4, 2009 | 1 | |
| Happy Days | January 15, 1974 | July 19, 1984 | 11 | |
| Happy Endings | April 13, 2011 | May 3, 2013 | 3 | |
| Harrigan and Son | October 14, 1960 | September 29, 1961 | 1 | |
| Have Faith | April 18, 1989 | June 13, 1989 | 1 | |
| He's the Mayor | January 10, 1986 | March 21, 1986 | 1 | |
| Head of the Class | September 17, 1986 | June 25, 1991 | 5 | |
| Help Me Help You | September 26, 2006 | December 12, 2006 | 1 | |
| Here Come the Brides | September 25, 1968 | April 3, 1970 | 2 | |
| Hi Honey, I'm Home! | July 19, 1991 | August 23, 1991 | Season 1 only; moved to Nick at Nite for season 2. | 1 |
| Hiller and Diller | September 23, 1997 | March 13, 1998 | 1 | |
| Holmes & Yoyo | September 25, 1976 | August 8, 1977 | 1 | |
| Home Economics | April 7, 2021 | January 18, 2023 | 3 | |
| Home Free | March 31, 1993 | July 2, 1993 | 1 | |
| Home Improvement | September 17, 1991 | May 25, 1999 | 8 | |
| Homeroom | September 16, 1989 | December 17, 1989 | 1 | |
| Hope & Faith | September 26, 2003 | May 2, 2006 | 3 | |
| Hot l Baltimore | January 24, 1975 | April 25, 1975 | 1 | |
| Hot Properties | October 7, 2005 | December 30, 2005 | 1 | |
| How to Live with Your Parents (For the Rest of Your Life) | April 3, 2013 | June 26, 2013 | 1 | |
| Hudson Street | September 19, 1995 | June 19, 1996 | 1 | |
| The Hughleys | September 22, 1998 | April 28, 2000 | Seasons 1–2 only; moved to UPN seasons 3–4. | 2 |
| I Married Dora | September 22, 1987 | January 8, 1988 | 1 | |
| I'm a Big Girl Now | October 31, 1980 | May 8, 1981 | 1 | |
| I'm Dickens, He's Fenster | September 28, 1962 | May 10, 1963 | 1 | |
| I'm with Her | September 23, 2003 | April 27, 2004 | 1 | |
| In Case of Emergency | January 3, 2007 | April 11, 2007 | 1 | |
| In the Motherhood | March 26, 2009 | June 25, 2009 | 1 | |
| Imaginary Mary | March 29, 2017 | May 30, 2017 | 1 | |
| It Takes Two | October 14, 1982 | April 28, 1983 | 1 | |
| It's a Living | October 30, 1980 | June 11, 1982 | Seasons 1–2 only; moved to first-run syndication seasons 3–6. | 2 |
| It's All Relative | October 1, 2003 | April 20, 2004 | 1 | |
| It's Like, You Know... | March 24, 1999 | January 5, 2000 | 2 | |
| It's Not Easy | September 29, 1983 | October 27, 1983 | 1 | |
| The Jackie Thomas Show | December 1, 1992 | April 30, 1993 | 1 | |
| Jake in Progress | March 13, 2005 | February 20, 2006 | 2 | |
| The Jeff Foxworthy Show | September 12, 1995 | May 15, 1996 | Season 1 only; moved to NBC season 2. | 1 |
| Joanie Loves Chachi | March 23, 1982 | May 24, 1983 | 2 | |
| The Job | March 14, 2001 | April 24, 2002 | 2 | |
| Julie | May 30, 1992 | July 4, 1992 | 1 | |
| Just for Laughs | August 8, 1974 | August 29, 1974 | 1 | |
| Just in Time | April 6, 1988 | May 11, 1988 | 1 | |
| Just Our Luck | September 20, 1983 | December 27, 1983 | 1 | |
| Just the Ten of Us | April 26, 1988 | May 4, 1990 | 3 | |
| The Kids Are Alright | October 16, 2018 | May 21, 2019 | 1 | |
| The Knights of Prosperity | January 3, 2007 | August 8, 2007 | 1 | |
| Last Man Standing | October 11, 2011 | March 31, 2017 | Seasons 1–6 only; moved to Fox for seasons 7–9. | 6 |
| Laurie Hill | September 30, 1992 | October 28, 1992 | 1 | |
| Laverne & Shirley | January 27, 1976 | May 10, 1983 | 8 | |
| Leave It to Beaver | October 2, 1958 | June 20, 1963 | Seasons 2–6 only; season 1 aired on CBS. | 5 |
| Less than Perfect | October 1, 2002 | June 20, 2006 | 4 | |
| Life with Bonnie | September 17, 2002 | April 9, 2004 | 2 | |
| Life with Lucy | September 20, 1986 | November 15, 1986 | 1 | |
| Life's Work | September 17, 1996 | June 10, 1997 | 1 | |
| Living Dolls | September 26, 1989 | December 30, 1989 | 1 | |
| Love, American Style | September 29, 1969 | January 11, 1974 | 5 | |
| Love That Jill | January 20, 1958 | April 14, 1958 | 1 | |
| Madigan Men | October 6, 2000 | December 15, 2000 | 1 | |
| Maggie | October 24, 1981 | May 21, 1982 | 1 | |
| Makin' It | February 1, 1979 | March 23, 1979 | 1 | |
| Malibu Country | November 2, 2012 | March 22, 2013 | 1 | |
| Man Up! | October 18, 2011 | December 6, 2011 | 1 | |
| Manhattan Love Story | September 30, 2014 | December 4, 2014 | The first 4 episodes only; the remaining 7 episodes were released on Hulu. | 1 |
| Married People | September 18, 1990 | March 16, 1991 | 1 | |
| Married to the Kellys | October 3, 2003 | April 23, 2004 | 1 | |
| Maybe This Time | September 15, 1995 | February 17, 1996 | 1 | |
| The Mayor | October 3, 2017 | December 12, 2017 | 1 | |
| McHale's Navy | October 11, 1962 | April 12, 1966 | 4 | |
| Me and the Boys | September 20, 1994 | February 28, 1995 | 1 | |
| The Middle | September 30, 2009 | May 22, 2018 | 9 | |
| Miss Guided | March 18, 2008 | April 3, 2008 | 1 | |
| Mixed-ish | September 24, 2019 | May 18, 2021 | 2 | |
| Mixology | February 26, 2014 | May 21, 2014 | 1 | |
| Modern Family | September 23, 2009 | April 8, 2020 | 11 | |
| Mork & Mindy | September 14, 1978 | May 27, 1982 | 4 | |
| Mr. Belvedere | March 15, 1985 | July 8, 1990 | 6 | |
| Mr. Sunshine | March 28, 1986 | May 24, 1986 | 1 | |
| Mr. Sunshine | February 9, 2011 | April 6, 2011 | 1 | |
| Mr. T and Tina | September 25, 1976 | October 30, 1976 | 1 | |
| The Muppets | September 22, 2015 | March 1, 2016 | 1 | |
| My Life and Times | April 24, 1991 | May 30, 1991 | 1 | |
| My Three Sons | September 29, 1960 | May 20, 1965 | Seasons 1–5 only; moved to CBS for seasons 6–12. | 5 |
| My Wife and Kids | March 28, 2001 | May 17, 2005 | 5 | |
| The Naked Truth | September 13, 1995 | February 28, 1996 | Season 1 only; moved to NBC for seasons 2–3. | 1 |
| The Nancy Walker Show | September 30, 1976 | December 23, 1976 | 1 | |
| Nanny and the Professor | January 21, 1970 | December 27, 1971 | 3 | |
| The Neighbors | September 26, 2012 | April 11, 2014 | 2 | |
| A New Kind of Family | September 16, 1979 | January 5, 1980 | 1 | |
| The New Odd Couple | October 29, 1982 | May 26, 1983 | 1 | |
| No Time for Sergeants | September 14, 1964 | May 3, 1965 | 1 | |
| Nobody's Perfect | June 26, 1980 | August 28, 1980 | 1 | |
| Not Dead Yet | February 8, 2023 | April 24, 2024 | 2 | |
| The Norm Show | March 24, 1999 | April 6, 2001 | 3 | |
| Notes from the Underbelly | April 12, 2007 | February 4, 2008 | 2 | |
| The Odd Couple | September 24, 1970 | March 7, 1975 | 5 | |
| Odd Man Out | September 24, 1999 | January 7, 2000 | 1 | |
| Off the Rack | December 7, 1984 | April 19, 1985 | 1 | |
| Oh Madeline | September 27, 1983 | March 13, 1984 | 1 | |
| Oh, Grow Up | September 22, 1999 | December 28, 1999 | 1 | |
| On Our Own | September 13, 1994 | April 14, 1995 | 1 | |
| On the Air | June 20, 1992 | July 4, 1992 | 1 | |
| On the Rocks | September 11, 1975 | May 17, 1976 | 1 | |
| Open All Night | November 28, 1981 | March 5, 1982 | 1 | |
| Operation Petticoat | September 17, 1977 | October 16, 1978 | 2 | |
| Out of the Blue | September 9, 1979 | December 16, 1979 | 1 | |
| The Partridge Family | September 25, 1970 | March 23, 1974 | 4 | |
| The Patty Duke Show | September 18, 1963 | April 27, 1966 | 3 | |
| The Paul Lynde Show | September 13, 1972 | March 14, 1973 | 1 | |
| Perfect Strangers | March 25, 1986 | August 6, 1993 | 8 | |
| Phenom | September 14, 1993 | May 10, 1994 | 1 | |
| Police Squad! | March 4, 1982 | July 8, 1982 | 1 | |
| Rango | January 13, 1967 | May 5, 1967 | 1 | |
| The Real McCoys | October 3, 1957 | May 10, 1962 | Seasons 1–5 only; moved to CBS season 6. | 5 |
| The Real O'Neals | March 2, 2016 | March 14, 2017 | 2 | |
| Reggie | August 2, 1983 | September 1, 1983 | 1 | |
| Regular Joe | March 28, 2003 | April 18, 2003 | 1 | |
| The Robert Guillaume Show | April 5, 1989 | August 1, 1989 | 1 | |
| Rodney | September 21, 2004 | June 6, 2006 | 2 | |
| Romantically Challenged | April 19, 2010 | May 17, 2010 | 1 | |
| Room for One More | January 27, 1962 | July 28, 1962 | 1 | |
| Room for Two | March 24, 1992 | July 6, 1993 | 2 | |
| The Ropers | March 13, 1979 | May 22, 1980 | 2 | |
| Roseanne | October 18, 1988 | May 22, 2018 | 10 | |
| The Ruggles | October 23, 1949 | June 19, 1952 | 4 | |
| Sabrina the Teenage Witch | September 27, 1996 | May 5, 2000 | Seasons 1–4 only; moved to The WB for seasons 5–7. | 4 |
| Samantha Who? | October 15, 2007 | July 23, 2009 | 2 | |
| The San Pedro Beach Bums | September 19, 1977 | December 19, 1977 | 1 | |
| Schooled | January 9, 2019 | May 13, 2020 | 2 | |
| Scrubs | January 6, 2009 | March 17, 2010 | Seasons 8–9 only; Seasons 1–7 aired on NBC. | 8–9 |
| The Second Hundred Years | September 6, 1967 | March 28, 1968 | 1 | |
| The Secret Lives of Men | September 30, 1998 | November 11, 1998 | 1 | |
| Selfie | September 30, 2014 | November 11, 2014 | The first 7 episodes only; the remaining 6 episodes were released on Hulu. | 1 |
| Sibs | September 17, 1991 | April 29, 1992 | 1 | |
| Single Parents | September 26, 2018 | May 13, 2020 | 2 | |
| Sister, Sister | April 1, 1994 | April 28, 1995 | Seasons 1–2 only; moved to The WB seasons 3–6. | 2 |
| The Slap Maxwell Story | September 23, 1987 | June 8, 1988 | 1 | |
| Sledge Hammer! | September 23, 1986 | February 12, 1988 | 2 | |
| The Smith Family | January 20, 1971 | June 7, 1972 | 2 | |
| Soap | September 13, 1977 | April 20, 1981 | 4 | |
| Something So Right | March 3, 1998 | July 7, 1998 | Season 2 only; season 1 aired on NBC. | 1 |
| Sons & Daughters | March 7, 2006 | April 4, 2006 | 1 | |
| Soul Man | April 15, 1997 | May 26, 1998 | 2 | |
| Speechless | September 21, 2016 | April 12, 2019 | 3 | |
| Spin City | September 17, 1996 | April 30, 2002 | 6 | |
| Splitting Up Together | March 27, 2018 | April 9, 2019 | 2 | |
| Sports Night | September 22, 1998 | May 16, 2000 | 2 | |
| Star of the Family | September 30, 1982 | December 9, 1982 | 1 | |
| Stat | April 16, 1991 | May 21, 1991 | 1 | |
| Step by Step | September 20, 1991 | August 15, 1997 | Seasons 1–6 only; moved to CBS for its seventh and final season. | 6 |
| Suburgatory | September 28, 2011 | May 14, 2014 | 3 | |
| Summer Fun | July 22, 1966 | September 2, 1966 | 1 | |
| The Super | June 21, 1972 | August 23, 1972 | 1 | |
| Super Fun Night | October 2, 2013 | February 19, 2014 | 1 | |
| Surviving Suburbia | June 4, 2009 | August 7, 2009 | 1 | |
| Tabitha | September 10, 1977 | January 14, 1978 | 1 | |
| Tammy | September 17, 1965 | March 11, 1966 | 1 | |
| Taxi | September 12, 1978 | May 6, 1982 | Seasons 1–4 only; moved to NBC for season 5. | 4 |
| Teen Angel | September 26, 1997 | February 13, 1998 | 1 | |
| Temperatures Rising | September 12, 1972 | August 29, 1974 | 2 | |
| That Girl | September 8, 1966 | March 19, 1971 | 5 | |
| That's My Mama | September 4, 1974 | December 24, 1975 | 2 | |
| The Texas Wheelers | September 13, 1974 | July 24, 1975 | 1 | |
| Thea | September 8, 1993 | February 16, 1994 | 1 | |
| Thicker than Water | June 13, 1973 | August 8, 1973 | 1 | |
| Three's a Crowd | September 25, 1984 | April 9, 1985 | 1 | |
| Three's Company | March 14, 1977 | September 18, 1984 | 8 | |
| Thunder Alley | March 9, 1994 | July 4, 1995 | 2 | |
| Too Close for Comfort | November 11, 1980 | May 5, 1983 | Seasons 1–3 only; moved to first-run syndication for seasons 4–6. | 3 |
| A Touch of Grace | January 20, 1973 | April 21, 1973 | 1 | |
| Townies | September 18, 1996 | December 4, 1996 | 1 | |
| Trophy Wife | September 24, 2013 | May 13, 2014 | 1 | |
| The Trouble with Normal | October 6, 2000 | November 3, 2000 | 1 | |
| Two Guys, a Girl, and a Pizza Place | March 10, 1998 | May 16, 2001 | 4 | |
| Two of a Kind | September 25, 1998 | July 9, 1999 | 1 | |
| Uncle Buck | June 14, 2016 | August 2, 2016 | 1 | |
| United We Fall | July 15, 2020 | August 26, 2020 | 1 | |
| Viva Valdez | May 31, 1976 | September 6, 1976 | 1 | |
| Webster | September 16, 1983 | May 8, 1987 | Seasons 1–4 only; moved to first-run syndication for seasons 5–6. | 4 |
| Welcome Back, Kotter | September 9, 1975 | May 17, 1979 | 4 | |
| Wendy and Me | September 14, 1964 | May 24, 1965 | 1 | |
| What About Joan? | March 27, 2001 | October 9, 2001 | 2 | |
| What's Happening!! | August 5, 1976 | April 28, 1979 | 3 | |
| When Things Were Rotten | September 10, 1973 | December 3, 1975 | 1 | |
| Where I Live | March 5, 1993 | November 20, 1993 | 2 | |
| Who's the Boss? | September 20, 1984 | April 25, 1992 | 8 | |
| A Whole New Ballgame | January 9, 1995 | March 13, 1995 | 1 | |
| Work It | January 3, 2012 | January 10, 2012 | 1 | |
| You Wish | September 26, 1997 | July 24, 1998 | 1 |
| Title | Premiere date | Finale | Notes |
|---|---|---|---|
| State V. | June 19, 2002 | June 19, 2002 | |
| 1969 | April 23, 2019 | May 28, 2019 | |
| The Last Dance | April 19, 2020 | May 17, 2020 | |
| The Con | October 14, 2020 | September 9, 2022 | |
| Soul of a Nation | March 2, 2021 | April 6, 2021 | |
| Mike Tyson: The Knockout | May 25, 2021 | June 1, 2021 | |
| Superstar | August 11, 2021 | June 14, 2023 | |
| Let the World See | January 6, 2022 | January 20, 2022 | |
| The Fatal Flaw: A Special Edition of 20/20 | July 7, 2022 | August 5, 2022 | |
| Bad Romance: A Special Edition of 20/20 | January 22, 2024 | March 11, 2024 | |
| The Interrogation Tapes: A Special Edition of 20/20 | April 1, 2024 | April 29, 2024 |