SpaceX CRS-35

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SpaceX CRS-35
NamesCRS SpX-35
Mission type ISS resupply
Operator SpaceX
COSPAR ID 2026-233A OOjs UI icon edit-ltr-progressive.svg
SATCAT no. 101031 OOjs UI icon edit-ltr-progressive.svg
Mission duration6 days, 13 hours, 50 minutes (in progress)
≈30 days (planned)
Spacecraft properties
SpacecraftCargo Dragon  C211
Spacecraft type Cargo Dragon
ManufacturerSpaceX
Start of mission
Launch dateOctober 13, 2026, 10:33:44  UTC (6:33:44 am  EDT) [1] [2]
Rocket Falcon 9 Block 5 (B1096‑8), Flight 695
Orbital parameters
Reference system Geocentric orbit
Regime Low Earth orbit
Docking with ISS
Docking port Harmony zenith
Docking dateOctober 15, 2026, 14:27 UTC
Undocking dateNovember 2026 (planned)
Time docked4 days, 9 hours, 57 minutes (in progress)
Cargo
Mass6,322 lb (2,868 kg) [1]
Pressurised3,687 lb (1,672 kg) [1]
Unpressurised2,635 lb (1,195 kg) [1]
SpaceX CRS-35 Patch.png
Mission insignia

SpaceX CRS-35, also known as SpX-35, is an International Space Station (ISS) cargo resupply mission contracted by NASA and operated by SpaceX. The flight launched on October 13, 2026 from Space Launch Complex 40 at Cape Canaveral Space Force Station. It is SpaceX's 35th cargo delivery mission under the Commercial Resupply Services program. [3]

Contents

Manifest [3]

The Cargo Dragon spacecraft was loaded with a total of 6,322 lb (2,868 kg) of cargo and supplies before its launch, including 3,687 lb (1,672 kg) of pressurized and 2,635 lb (1,195 kg) of unpressurized cargo.

The cargo manifest includes:

Research

A variety of experiments will be transported to the ISS, providing insight for researchers and the broader scientific community.

CRS-35 carried replacement ISS Roll Out Solar Arrays. [1] The mission also carried a payload designed by Langston University. [4]

LambdaVision-1

LambdaVision-1 investigates the production of artificial retinal tissue in microgravity. Researchers are studying whether depositing the tissue in successive thin layers in microgravity can produce more uniform and stable material. The research could contribute to the development of artificial retinas for patients with retinal diseases. [3]

Stellar Spheroids

Stellar Spheroids studies the growth and function of three-dimensional human heart-tissue models in microgravity. Researchers are examining whether the space environment promotes the formation of vascular networks within the tissue. The findings could help improve models used to study cardiovascular disease and evaluate the effects of drugs on heart function. [3]

ELF-Unconventional Glass 2

ELF-Unconventional Glass 2 investigates how glass made from non-traditional elements forms in microgravity. Researchers will observe the behavior of molten glass in space and analyze the resulting samples after their return to Earth. The work could inform the development of glasses with improved mechanical, optical, or durability properties for use in spacecraft and other technologies. [3]

MINDS

The MINDS investigation studies brain organoids to investigate neuroinflammation associated with neurodegenerative diseases. Its experimental approach includes combining cells from multiple individuals into organoid models, allowing researchers to examine biological responses across a more diverse set of cells. The research could help identify potential therapeutic targets for diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. [3]

AVATAR-Org1

AVATAR-Org1 investigates the effects of spaceflight on human brain tissue using small, laboratory-grown three-dimensional models called miBrains. The models are to remain aboard the ISS for five weeks and are compared with corresponding tissue maintained on Earth. The investigation aims to characterize cellular changes associated with spaceflight and assess whether human brain tissue can be reliably grown and studied in space. [5]

MVP-Plant-02

MVP-Plant-02 investigates whether crop diseases develop more rapidly or become more severe in microgravity. Researchers compare infected plants grown aboard the space station with corresponding plants grown on Earth, examining molecular and structural changes caused by the disease. The findings could inform the development of disease-resistant crops for agriculture on Earth and future space missions. [6]

Commercially Enabled Rapid Space Science

The Commercially Enabled Rapid Space Science initiative includes an evaluation of a compact microplate reader for analyzing biological samples aboard the ISS. The experiment tests the device's ability to measure biomarkers, including antibodies, antigens, and proteins. Rapid onboard analysis could help researchers detect infections and other health issues in astronauts without having to wait for samples to be returned to Earth. [7]

Tumor AVatars in Space (TAVIS)

Researchers at the Wake Forest Institute for Regenerative Medicine are using tumor tissue organoids grown from patient-derived colorectal cancer cells to investigate responses to chemotherapy under microgravity, and to identify potential targets for new cancer treatments. The research aims to improve chemotherapy response in patients and support the development of more personalized treatment strategies. [8]

A research project led by the University of California, San Diego, investigates the forces involved in mudflows and debris flows that can occur after wildfires. Experiments in microgravity help researchers examine particle behavior and flow dynamics while reducing the influence of gravity-driven effects that complicate measurements on Earth. The findings could contribute to improved models for predicting these natural hazards. [8]

Genes in Space protein-production experiment

A student-led investigation from the Genes in Space program studies protein production in microgravity. The experiment tests multiple DNA sequences that encode the same protein to determine which sequences support more efficient protein production in space. The results could inform future biological manufacturing applications, including the production of therapeutics and other materials during long-duration space missions. [8]

SCAMPI

CRS-35 also carried three live Halocaridina rubra shrimp as part of the SCAMPI Project, an initiative carried out between 51 students at The Spring Institute for Forests on the Moon, École Polytechnique, ISAE-SUPAERO, IPSA, École d'ingénieurs de PURPAN, Politecnico di Torino, University of Trento, University of Pavia, Utrecht University, TU Delft, Queen Mary University of London, and the University of Arizona. [9] [10]

Student Spaceflight Experiements Program

CRS-35 also carried the Atlantis and Discovery experiments payload for the Student Spaceflight Experiments Program (SSEP), corresponding to Missions 20 and 21 respectively. The investigations cover a range of subjects, including seed germination, crystal growth, cell biology, and materials science. Each community is based on a K-12 school or college/university. Payload includes:

[11] [12]
MissionInstitution [13] [14] CommunityExperiment
20 Central Alabama Community College Alexander City, ALInvestigating the Effects of Microgravity on the Early Root Development Rate of Radishes
20 Morgan Community College Fort Morgan, COEffects of Zero Gravity on The Germination of Radishes in Hydrogel
20 Florida Institute of Technology Melbourne, FLHydrogel Radiation-Shielding Viability Under the Influence of Microgravity
20 University of Tennessee Knoxville, TNThe Effects of Space Travel on Speed Germination and Plant Stress
21 Edmonton Public Schools Edmonton, AB, CanadaHow Does Microgravity Affect the Oxidation of Copper in a Vinegar, Salt, and Water Solution?
21 R. Tait Mckenzie Public School Mississippi Mills, ON, CanadaWould broccoli sprout faster in low gravity?
21 Paradise Valley Unified School District Phoenix, AZThe Effect of Microgravity on the Growth and Structure of Covalent Organic Frameworks (COFs)
21 Pasadena City College Pasadena, CAThe Effect of Microgravity on the Crystallogenesis of Hen Egg White Lysozyme
21 University of Colorado, Colorado Springs Colorado Springs, COSpace Climate Seeds: Investigating Osmotic Stress-Primed Germination in Microgravity
21 Florida Insitute of Technology Melbourne, FLEffects of Microgravity on Neurodegeneration using Tauopathy Model
21 St. Petersburg College St. Petersburg, FLThe Effect of Microgravity on the Formation and Properties of Calcium Alginate Hydrogels
21 University of South Florida Tampa, FLMicrogravity Effects on Chitosan Hydrogel Structure for Potential Wound-Care Applications
21 Tulane University New Orleans, LACoacervate Protocells in Microgravity: Stability, Function, and Implications for the Origins of Life Beyond Earth
21 UMass Lowell Lowell, MAAging and Coarsening of Milk-Protein Micelles
21 Metropolitan Community College Omaha, NERadiation Detection via Dosimeter Near Solar Maximum
21 City School Distirct of Albany Albany, NYThe effects of microgravity on red maple tree seed germination
21 ABTech Community College Asheville, NCHow are lubricating oils affected by space travel?
21 Ohio University Athens, OHExamining the Effect of Microgravity on the Metabolism of the Antihistamine Promethazine HCl, using Caenorhabditis elegans as a Model
21 Community College of Allegheny County Pittsburgh, PAEvaluating the Effect of Microgravity on Insulin Activity and Glucose Regulation Post-Flight
21 North East Independent School District San Antonio, TXThe Effects of Microgravity on the Growth of Stems and Roots in Length and Direction of Rye Plants
21 Grantsburg School District iForward-Grantsburg, WIThe germination and growth of lentil sprouts in microgravity

Launch

CRS-35 was originally scheduled to launch in November 2026. However, during the launch of Soyuz MS-28 for the ISS on 27 November 2025, the launch pad at the Baikonur Cosmodrome's Site 31 suffered extensive damage and was rendered inoperable, resulting in an acceleration of future resupply missions. [1] [15] In December 2025, CRS-35's launch was to be accelerated to August 2026. [15] [16] Following the rapid repair of Site 31, CRS-35 was moved back to fall 2026. [1]

References

  1. 1 2 3 4 5 6 7 Garcia, Mark A. "NASA, Partners Update International Space Station 2026 Flight Plan". NASA . Retrieved August 1, 2026.
  2. ↑ Low, Lauren E. "NASA Invites Media to SpaceX's 35th Resupply Launch to Space Station - NASA" . Retrieved September 17, 2026.
  3. 1 2 3 4 5 6 "NASA's SpaceX 35th Commercial Resupply Mission Overview". NASA . Retrieved October 13, 2026.
  4. ↑ Frank, Nehemiah. "Langston University begins new strategic plan, expands leadership team". The Black Wall Street Times . Retrieved September 19, 2026.
  5. ↑ "AVATAR-Org1 - NASA Science". September 26, 2026. Retrieved October 13, 2026.
  6. ↑ "MVP (Multi-Use Variable-g Platform)-Plant-02 - NASA Science". September 26, 2026. Retrieved October 13, 2026.
  7. ↑ "NASA's SpaceX CRS-35 Mission to Launch Health Research - NASA Science". October 12, 2026. Retrieved October 13, 2026.
  8. 1 2 3 Elkavich, Amy (October 13, 2026). "Biomedical Studies, NSF-Funded Science, Student-Led Projects, and More on NASA's SpaceX CRS-35". ISS National Lab. Retrieved October 13, 2026.
  9. ↑ Sauvage, Valérie (October 9, 2026). "« C'est un rêve, un rêve concret ! » : trois crevettes partiront bientôt à la conquête de l'espace et c'est une première !". La Voix du Nord (in French). Retrieved October 12, 2026.
  10. ↑ "The Spring Institute" . Retrieved October 12, 2026.
  11. ↑ "SSEP Mission 20 to ISS: Experiment Log | SSEP | Student Spaceflight Experiments Program" . Retrieved October 13, 2026.
  12. ↑ "SSEP Mission 21 to ISS: Experiment Log | SSEP | Student Spaceflight Experiments Program" . Retrieved October 13, 2026.
  13. ↑ "Community Profiles and Local Partners: SSEP Mission 20 to ISS | SSEP Community Network" . Retrieved October 13, 2026.
  14. ↑ "Community Profiles and Local Partners: SSEP Mission 21 to ISS | SSEP Community Network" . Retrieved October 13, 2026.
  15. 1 2 Berger, Eric. "After key Russian launch site is damaged, NASA accelerates Dragon supply missions". Ars Technica . Retrieved August 1, 2026.
  16. ↑ Tribou, Richard. "Space Coast launch schedule". Orlando Sentinel . Retrieved August 3, 2026.
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