S42 (selective androgen receptor modulator)

S42 (selective androgen receptor modulator)

Identifiers
IUPAC name 1-[(8S,9S,13S,14S,17S)-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]ethanone
Chemical and physical data
Formula	C21H28O
Molar mass	296.454 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3cccc4C)[C@@H]1CC[C@@H]2C(=O)C
InChI InChI=1S/C21H28O/c1-13-5-4-6-16-15(13)7-8-18-17(16)11-12-21(3)19(14(2)22)9-10-20(18)21/h4-6,17-20H,7-12H2,1-3H3/t17-,18-,19-,20+,21-/m1/s1 Key:QHOSKNZHWGWGMX-SSSFQFABSA-N

S42 is a fully synthetic steroidal selective androgen receptor modulator (SARM) developed for the treatment of muscle wasting in the elderly. ^{[1] [2] [3] [4]}

See also

• MK-4541
• YK-11

References

1. US 8623909,Nawata H, Yanase T, Nakagawa T,"Prophylactic/therapeutic agents for lifestyle-related diseases.",issued 7 January 2014, assigned to Aska Pharmaceutical Co Ltd. 
2. Muta Y, Tanaka T, Hamaguchi Y, Hamanoue N, Motonaga R, Tanabe M, et al. (March 2019). "Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes". Biochemistry and Biophysics Reports. 17: 177–181. doi:10.1016/j.bbrep.2019.01.006. PMC   6348734 . PMID   30705972.
3. Wen HC, Wilczek T, Neudörfl JM, Wagener F, Piper T, Thevis M, et al. (August 2024). "A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42". Journal of Mass Spectrometry. 59 (8): e5077. doi:10.1002/jms.5077. PMID   39102231.
4. Wen HC, Wagener F, Piper T, Neudörfl J, Thevis M, Schäfer M (March 2025). "Investigations Into Structures of In Vitro-Derived Phase I Metabolites of a Novel 20-Keto-Steroid S42 by GC-EI HR MS Analysis and Chemical Synthesis". Drug Testing and Analysis. doi:10.1002/dta.3890. PMID   40159391.