Triamcinolone furetonide

Triamcinolone furetonide
Clinical data
Other names	HE-192; Triamcinolone acetonide 21-(2-benzofurancarboxylate); 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-(2-benzofurancarboxylate)
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 1-benzofuran-2-carboxylate;
CAS Number	4989-94-0 ;
PubChem CID	62964 ;
ChemSpider	56675 ;
UNII	O49NOC9ROC ;
ChEMBL	ChEMBL2105791 ;
CompTox Dashboard (EPA)	DTXSID00198138 ;
ECHA InfoCard	100.023.319
Chemical and physical data
Formula	C33H35FO8
Molar mass	578.633 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)COC(=O)C5=CC6=CC=CC=C6O5)CCC7=CC(=O)C=C[C@@]73C)F)O;
	InChI InChI=1S/C33H35FO8/c1-29(2)41-27-15-22-21-10-9-19-14-20(35)11-12-30(19,3)32(21,34)25(36)16-31(22,4)33(27,42-29)26(37)17-39-28(38)24-13-18-7-5-6-8-23(18)40-24/h5-8,11-14,21-22,25,27,36H,9-10,15-17H2,1-4H3/t21-,22-,25-,27+,30-,31-,32-,33+/m0/s1; Key:OSWKQSQWSQSPQH-GNFRAIDCSA-N;

Last updated September 06, 2024

Triamcinolone furetonide (developmental code name HE-192; also known as triamcinolone acetonide 21-(2-benzofurancarboxylate)) is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]^[3]

Related Research Articles

<span class="mw-page-title-main">Triamcinolone</span> Steroid medication

Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening of asthma and COPD. It can be taken in various ways including by mouth, injection into a muscle, and inhalation.

Triamcinolone acetonide, sold under the brand name Kenalog among others, is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions. It is also injected into lesions to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is used for the treatment of macular edema associated with uveitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.

Triamcinolone hexacetonide is a synthetic glucocorticoid corticosteroid.

<span class="mw-page-title-main">Prednimustine</span> Chemical compound

Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas. It is the ester formed from two other drugs, prednisolone and chlorambucil. Rarely, it has been associated with myoclonus.

Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid.

Clostebol acetate is a synthetic, injected anabolic-androgenic steroid (AAS) and a derivative of testosterone that is marketed in Germany and Italy. It is an androgen ester – specifically, the C17β acetate ester of clostebol (4-chlorotestosterone) – and acts as a prodrug of clostebol in the body. Clostebol acetate is administered via intramuscular injection.

Androstenediol dipropionate, or 5-androstenediol 3β,17β-dipropionate, also known as androst-5-ene-3β,17β-diol 3β,17β-dipropionate, is a synthetic anabolic–androgenic steroid and an androgen ester – specifically, the dipropionate diester of 5-androstenediol (androst-5-ene-3β,17β-diol) – which has been marketed in Europe, including in Spain, Italy, and Austria.

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<span class="mw-page-title-main">Acrocinonide</span> Chemical compound

Acrocinonide is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Amcinafal</span> Chemical compound

Amcinafal, also known as triamcinolone pentanonide, is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Amcinafide</span> Chemical compound

Amcinafide, also known as triamcinolone acetophenide, is a synthetic glucocorticoid corticosteroid which was never marketed.

<span class="mw-page-title-main">Flupamesone</span> Chemical compound

Flupamesone, also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide.

Triamcinolone aminobenzal benzamidoisobutyrate is a synthetic glucocorticoid corticosteroid which is no longer marketed.

<span class="mw-page-title-main">Acetophenide</span>

In organic chemistry, acetophenide is a functional group which is composed of the cyclic ketal of a diol with acetophenone. In pharmaceutical chemistry, it is present in algestone acetophenide and amcinafide.

<span class="mw-page-title-main">Acroleinide</span>

In organic chemistry, acroleinide is a functional group which is composed of a cyclic ketal of a diol with acrolein. In pharmaceutical chemistry, it is present in acrocinonide.

In organic chemistry, pentanonide is a functional group which is composed of a cyclic ketal of a diol with 3-pentanone. It is seen in amcinafal.

In organic chemistry, cyclopentanonide is a functional group which is composed of a cyclic ketal of a diol with cyclopentanone. It is seen in amcinonide.

In organic chemistry, aminobenzal is a functional group which is composed of a cyclic ketal of a diol with 4-dimethylaminobenzylidene. It is seen in triamcinolone aminobenzal benzamidoisobutyrate.

References

↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1228–. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1657–. ISBN 978-3-88763-075-1.
↑ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 280–. ISBN 978-94-011-4439-1.

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[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1228–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1657–. ISBN 978-3-88763-075-1.

[MortonHall2012-3] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 280–. ISBN 978-94-011-4439-1.

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