| Woolly monkey sarcoma virus | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Pararnavirae |
| Phylum: | Artverviricota |
| Class: | Revtraviricetes |
| Order: | Ortervirales |
| Family: | Retroviridae |
| Genus: | Gammaretrovirus |
| Species: | Gammaretrovirus woomonsar |
Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called Sulfolobus spindle-shaped virus, that belong to different genera in family Fuselloviridae ) is a species of gammaretrovirus that infects primates. First isolation was from a fibrosarcoma in a woolly monkey ( Legothrix lagothrica ). For its reproduction the virus needs a helper or associated virus which is called Simian sarcoma associated virus (SSAV), [1] [2] [3] also known as woolly monkey virus (WMV). [4]
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The WMSV/SSV genome is nearly identical to the WMV/SSAV genome, except the part corresponding to the env gene on the WMV/SSAV genome [5] is replaced by an oncogene called p28/v-sis. The lack of an env renders it reliant on the SSAV for reproduction while the presence of the oncogene makes it sarcoma-causing. v-sis is derived from a primate [6] PDGFB (c-sis) gene that the ancestral WMSV/SSV had picked up instead of its own env gene. [7]
