| Name | Release date | Developer/publisher |
|---|
| Safety Monkey | 1994 | Viridis Corporation, IVI Publishing |
| Sammy's Science House | 1994 | Theatrix Interactive, Edmark |
| SCAT | 1994 | Bob Dolan |
| Science Shop with Monker | 1995 | Information Technology Design Associates, Western Publishing Company |
| Science Sleuths | 1996 | Videodiscovery |
| Scissors, Paper, Stone | 1991 | David McIntosh |
| Score Builder for SAT | 1995 | Compton's Learning |
| Scrabout | 1995 | Lance Frohman |
| Search and Destroy | 1992 | Randy Baron |
| Secrets of the Pyramids | 1994 | Ednovation, Mindscape |
| Sensible Golf | 1994 | Sensible Software, Virgin Interactive |
| Sesame Street: Art Workshop | 1995 | Children's Television Workshop, Creative Wonders |
| Sesame Street: Elmo's Preschool | 1997 | Children's Television Workshop, Creative Wonders |
| Sesame Street: Get Set To Learn | 1996 | Creative Wonders, Electronic Arts |
| Sesame Street: Let's Make a Word! | 1995 | Children's Television Workshop, Creative Wonders |
| Sesame Street: Letters | 1995 | Children's Television Workshop, Creative Wonders |
| Sesame Street: Numbers | 1995 | Children's Television Workshop, Creative Wonders |
| Shadowgate | 1993 | ICOM Simulations, Inc., Viacom New Media |
| Shadows of Cairn | 1994 | Ant Software, Masque Publishing |
| Shanghai: Great Moments | 1995 | Quicksilver Software, Activision |
| Shanghai II: Dragon's Eye | 1994 | Activision |
| Shooter | 1993 | Albert C. Ashton |
| Shop Drop | 199? | Dynotech Software |
| ShotGun | December 16, 1993 | Albert C. Ashton, PCSTS |
| Pirates! Gold | 1994 | MPS Labs, MicroProse |
| SimAnt | 1991 | Maxis |
| SimCity | 1992 | Maxis |
| SimCity 2000 | 1994 | Maxis, Electronic Arts |
| SimEarth | 1990 | Maxis |
| SimFarm | 1993 | Maxis, Mindscape |
| SimJack | 1995 | Keith Marting |
| SimLife | 1992 | Maxis |
| Simon | 1991 | Mark Gamber |
| The Simpsons Cartoon Studio | 1996 | Big Top Productions, Fox Interactive |
| SimTower | 1994 | OPeNBooK Co., Ltd., Maxis |
| SinkSub | 1993 | Anders Wihlborg |
| SinkSub Pro | 1996 | Anders Wihlborg |
| Six Feet Under [1] | 1994 | EnQue Software |
| Skifree | 1991 | Chris Pirih |
| Slam! | 1993 | Robert Epps |
| Slot Machine | 1990 | Brett McDonald |
| Smash'em | 1995 | Galt Technology |
| Smithsonian Institution: Dinosaur Museum | 1997 | Perspective Visuals |
| Smelly Mystery Starring Mercer Mayer's Little Monster Private Eye, The | 1997 | Big Tuna New Media, GT Interactive |
| Snakes | 1991 | Kevin L. Patch |
| Snoopy's Campfire Stories | 1996 | Virgin Sound and Vision |
| Soccer Management Simulator | 1994 | Serious Games |
| Sokoban for Windows | 1992 | Allan B. Liss |
| Solar Vengeance | 1994 | Silicon Commander Games |
| Solitaire | 1990 | Microsoft Corporation |
| Solitaire Golf | 1990 | Steve Laterra |
| Space Bucks | 1996 | Impressions Games, Sierra On-Line |
| Space Dodge'm | 1994 | P. Steve Neeley |
| Space Exploration - Mission Alpha | 1992 | Jeffrey R. Marken |
| Space Guard | 1995 | Cosmi Corporation |
| SpaceRocks | 1994 | Eric Lee Steadle, Brian Lowes, Warped Software NQI |
| Space Rocks | 1993 | Adam J. Taub, Himom Inc. |
| Space Traveler | 1993 | Jeffrey R. Marken |
| Space Walls | 1990 | Adam J. Taub, Himom Inc. |
| Space Walls II | 1992 | Adam J. Taub, Himom Inc. |
| Span-It! | 1993 | Mark T. Chapman |
| Spectre VR | 1993 | Velocity Development |
| Spellbound! | 1993 | The Learning Company |
| Spelling Blizzard | 1994 | Bright Star Technology, Sierra On-Line |
| Spelling Jungle | 1993 | Bright Star Technology, Sierra On-Line |
| Spider | 1991 | Mark U. Edwards |
| Spider, Double Deck Solitaire | 1992 | Troy Miller |
| Squeaky Mouse | 1994 | Toru Eguchi, ike |
| SqueezePlay | 1992 | Henderson Graphics |
| Squirmer | 1994 | Christopher Cifra |
| Stanley's Sticker Stories | 1996 | Edmark |
| Star Wars Chess | 1993 | Software Toolworks |
| Stardate 2140.2: Battles on Distant Planets | 1992 | Glacier Edge Technology |
| Stax | 1993 | Chris Dyer |
| Stellar Empires | 1993 | Tahuya Bay Software |
| Stellar Explorer | 1992 | Technological Computer Innovations |
| Stellar Warrior | 1992 | Michael McAuliffe |
| Stop the Bus | 1994 | Martin Davidson |
| Storybook Weaver | 1994 | MECC |
| Storybook Weaver Deluxe | 1995 | MECC |
| Strategy Challenges Collection | 1991 | Edmark |
| Strategy Challenges Collection 2: In the Wild | 1997 | Edmark |
| Street Shuffle | 1994 | Max Eissler, Maxware |
| Student Writing Center | 1994 | The Learning Company |
| Student Writing & Research Center | 1995 | The Learning Company |
| Super Craps | 1993 | Chris Peterson |
| Super Tetris | 1991 | Sphere, Inc., Spectrum Holobyte |
| Super Video Poker | 1993 | Elton M. Inada |
| SwatM | 1993 | Jim Fox, Mainstay Computer |