The following highways are numbered 486:
| Preceded by 485 | Lists of highways 486 | Succeeded by 487 |
National Route 486 is a national highway of Japan connecting between Sōja, Okayama and Higashihiroshima, Hiroshima in Japan. It has a total length of 130.8 km (81.27 mi).
King's Highway 109, or Highway 109, is a former provincial highway in Ontario. It was used on two separate, unrelated routes during the 1950s and 1960s:
