Route 380 or Highway 380 may refer to:
Interstate 380 
U.S. Route 380 
Arizona State Route 380 (cancelled proposal)
Arkansas Highway 380 
Georgia State Route 380 
Louisiana Highway 380 
Maryland Route 380 
New York State Route 380 (former)
Ohio State Route 380 
Oregon Route 380 
Pennsylvania Route 380 
Puerto Rico Highway 380 
Tennessee State Route 380 | Preceded by 379 | Lists of highways 380 | Succeeded by 381 |
U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate 30, of which the easternmost 3–4 miles are concurrent with US 69 in a loop around the west and south sides of Greenville. Its western terminus is at San Antonio, New Mexico, south of Socorro at an intersection with Interstate 25. It intersected with its parent, U.S. Route 80, at Cisco until 1971, when it was rerouted along the former SH 24 from that highway's western terminus near Old Glory to Greenville. Former U.S. Route 380 from Cisco to near Old Glory became an extension of SH 6. The highway no longer connects to any x80 route. US 380 passes through some of the far northern suburbs of the Dallas/Fort Worth Metroplex, including Denton, Frisco, McKinney and Princeton. The portion in Texas from the New Mexico state line to Jayton was SH 84 before 1939. Its spur, SH 84A, went from Jayton to Aspermont, until 1930, when it became SH 161.
Interstate 380 (I-380) is a short 3.3-mile (5.3 km) east–west auxiliary Interstate Highway in the San Francisco Bay Area of Northern California, connecting I-280 in San Bruno to US Route 101 (US 101) near San Francisco International Airport. The highway primarily consists of only three intersections: I-280, State Route 82, and US 101. Like the nearby I-280, I-380 never connects to I-80, its parent Interstate Highway. However, there is no rule that says that spur routes need to do so.
The Avenue of the Saints is a 563-mile-long (906 km) highway in the Midwestern United States that connects St. Louis, Missouri, and St. Paul, Minnesota.
Interstate 380 (I-380) is an auxiliary Interstate Highway in Northeastern Pennsylvania that connects I-80 with I-81 and I-84. The southern terminus is in Tunkhannock Township at the junction with I-80; the northern terminus of I-380 is at I-81 and U.S. Route 6 (US 6) in Dunmore. The entire length of the highway is 28.45 miles (45.79 km).
Interstate 82 (I-82) is the former designation for the following Interstate Highways between Scranton, Pennsylvania, and New York City:
