The following highways are numbered 600:
| Preceded by 599 | Lists of highways 600 | Succeeded by 601 |
U.S. Route 92 or U.S. Highway 92 is a 181-mile (291 km.) U.S. Route entirely in the U.S. state of Florida. The western terminus is at US 19 Alt. and SR 687 in downtown St. Petersburg. The eastern terminus is at SR A1A in Daytona Beach.
U.S. Route 192 is an east–west route of the United States Numbered Highway system in central Florida. It runs 75.04 miles (120.77 km) from U.S. Route 27 in Four Corners, Lake County, east past Walt Disney World and through Kissimmee, St. Cloud and Melbourne, to end at State Road A1A in Indialantic, one block from the Atlantic Ocean. It crosses its "parent", U.S. Route 92, in Kissimmee, for only 3,700 feet (1,100 m).
State Route 6 (SR 6) is a state highway that is unsigned. It travels through the central part of the U.S. state of Tennessee from Lawrence County to Sumner County. The highway is related to the following U.S. Highways:
