The following highways are numbered 12E:
E12 or E-12 may refer to:
New York State Route 12E (NY 12E) is a state highway located entirely within the northwestern part of Jefferson County in northern New York in the United States. The southern terminus is at NY 12F in the village of Brownville. Its northern terminus, both signed and official, is at NY 12 in the village of Clayton. While NY 12 follows a direct north–south routing between Watertown and Clayton, NY 12E diverges westward to follow the shoreline of Lake Ontario. The portion of NY 12E north of its junction with NY 180 is part of the Seaway Trail, a National Scenic Byway.
New York State Route 180 (NY 180) is a north–south state highway in the northwestern part of Jefferson County in the U.S. state of New York. The southern terminus of the route is at NY 3 in the Hounsfield hamlet of Baggs Corner, located 7 miles (11 km) west of downtown Watertown. The northern terminus is at NY 12 in the Orleans hamlet of Fishers Landing. NY 180 is part of the Seaway Trail from its southern terminus at Baggs Corner to its junction with NY 12E at the Brownville hamlet of Limerick.
New York State Route 12F (NY 12F) is an east–west state highway in Jefferson County, New York, in the United States. It extends for 6.89 miles (11.09 km) from an intersection with NY 180 in the town of Hounsfield to a junction with U.S. Route 11 (US 11) and NY 12 in the city of Watertown. The route follows a parallel routing to that of NY 12E between the vicinity of the village of Dexter and the city of Watertown. While NY 12E runs along the north side of the Black River through this area, NY 12F follows the southern bank. Just east of NY 180, NY 12F serves Watertown International Airport.
King's Highway 95, commonly referred to as Highway 95, was a provincially maintained highway in the Canadian province of Ontario on Wolfe Island. Together with Highway 96, the routes were the only King's Highways not connected to the rest of the network by a fixed link. At its southern end, the 11.4-kilometre (7.1 mi) route connected to New York State Route 12E via the private and seasonal Horne's Ferry. At its northern end, it connected with Highway 96 in Marysville a short distance west of the MV Wolfe Islander III ferry to Kingston. Today it is under the jurisdiction of Frontenac Islands Township, as Frontenac County does not have a county road system.