The following highways are numbered 621:
| Preceded by 620 | Lists of highways 621 | Succeeded by 622 |
State Route 621 is a north–south state highway in the central part of the U.S. state of Ohio. The southern terminus of SR 621 is at U.S. Route 36 approximately two and a half miles (4.0 km) northeast of Coshocton, and its northern terminus is adjacent to the North Appalachian Experimental Watershed Station, just north of its intersection with White Eyes Township Road 188, about 5 miles (8.0 km) northwest of the hamlet of Fresno. Continuing north after SR 621 ends is County Road 190.
State Route 6 (SR 6) is a state highway that is unsigned. It travels through the central part of the U.S. state of Tennessee from Lawrence County to Sumner County. The highway is related to the following U.S. Highways:
State Route 106 is a north–south state highway in Middle Tennessee. The highway is a secret, or hidden, designation for the following highways:
