The following highways are numbered 749:
| Preceded by 748 | Lists of highways 749 | Succeeded by 750 |
State Route 90 is a primary state highway in the U.S. state of Virginia. Known as Main Street, the state highway runs 1.73 miles (2.78 km) from SR 616 and SR 749 north to Interstate 81 (I-81) within Rural Retreat in western Wythe County. SR 90 connects Rural Retreat with I-81 and U.S. Route 11.
King's Highway 109, or Highway 109, is a former provincial highway in Ontario. It was used on two separate, unrelated routes during the 1950s and 1960s:
