Route 105 or Highway 105 may refer to:
A105 road
Interstate 105 
Alabama State Route 105 
Arkansas Highway 105 
Colorado State Highway 105 
Florida State Road 105 
Georgia State Route 105 
Georgia State Route 105 (1932–1937) (former)
Illinois Route 105 
Indiana State Road 105 
Iowa Highway 105 (former) 
K-105 (Kansas highway) 
Kentucky Route 105 
Louisiana Highway 105 
Louisiana State Route 105 (former)
Maine State Route 105 
Maryland Route 105 (former)
Massachusetts Route 105 
M-105 (Michigan highway) (former)
Minnesota State Highway 105 
Missouri Route 105 
Nebraska Highway 105 
County Route 105 (Bergen County, New Jersey) 
New Mexico State Road 105 
New York State Route 105 
County Route 105 (Dutchess County, New York) 
County Route 105 (Erie County, New York) 
County Route 105 (Montgomery County, New York) 
County Route 105 (Nassau County, New York) County Route 105 (Niagara County, New York) County Route 105 (Onondaga County, New York) 
County Route 105 (Orange County, New York) County Route 105 (Seneca County, New York) County Route 105 (Steuben County, New York) 
County Route 105 (Suffolk County, New York) 
County Route 105 (Sullivan County, New York) County Route 105 (Tompkins County, New York) 
North Carolina Highway 105 
Ohio State Route 105 
Oklahoma State Highway 105 
Pennsylvania Route 105 (former)
South Carolina Highway 105 
South Dakota Highway 105 (former)
Tennessee State Route 105 
Texas State Highway 105 
Utah State Route 105 
Vermont Route 105 
Virginia State Route 105 
Washington State Route 105 
West Virginia Route 105 
Wisconsin Highway 105 | Preceded by 104 | Lists of highways 105 | Succeeded by 106 |
