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This is a list of notable Canadian pizza chains. This list is limited to pizza chain restaurants that are based in or originated in Canada:
Uno Pizzeria & Grill, or more informally as Uno’s, is a United States-origin franchised pizzeria restaurant chain under the parent company Uno Restaurant Holdings Corporation. Uno Pizzeria and Grill is best known for its Chicago-style deep dish pizza. Ike Sewell opened the first Pizzeria Uno in 1943.
Spizzico is a chain of franchised quick-service pizzerias owned by the Italian-based multinational catering company Autogrill.
Sarpino's Pizzeria is a Canadian fast food restaurant chain specializing in pizza, with international operations headquartered in Singapore and U.S. operations headquartered in the Chicago suburb of Lincolnshire, Illinois.
Pieology Pizzeria is a Tustin, California-based pizza chain within the fast-casual dining restaurants category. Founded in 2011 by Carl Chang, the brother of former tennis player Michael Chang, Pieology's mission is to "turn one of America's favorite food into an affordable and interactive experience". Pieology's main rivals are Blaze Pizza and MOD Pizza. By October 2018, Pieology had a single unit in Mexico plus approximately 140 units in 23 American states and territories with more than half of those restaurants located in the state of California.
Canada has many of its own pizza chains, both national and regional, and many distinctive regional variations and types of pizza resulting from influences of local Canadian cuisine.