| Name | Mark | System [nb 1] | From | To | Successor | Notes |
|---|
| A&R Line, Inc. | ARE | | 1995 | | | Still exists as a lessor of Toledo, Peoria and Western Railway |
| Algers, Winslow and Western Railway | AWW | | 1927 | 2007 | Norfolk Southern Railway |
| American Central Railway | | NKP | 1859 | 1864 | Cleveland, Fort Wayne and Chicago Railroad |
| Anderson Belt Railway | | PRR | 1891 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Anderson, Lebanon and St. Louis Railway | | NYC/ PRR | 1871 | 1882 | Cleveland, Indiana and St. Louis Railway |
| Atchison, Topeka and Santa Fe Railway | ATSF | | 1983 | 1989 | Toledo, Peoria and Western Railway |
| Attica, Covington and Southern Railway | | WAB | 1879 | 1903 | Wabash Railroad |
| Attica and Terre Haute Railroad | | C&EI | 1860 | 1872 | Chicago, Danville and Vincennes Railroad |
| Auburn and Eel River Valley Railroad | | PRR | 1853 | 1853 | Logansport and Northern Indiana Railroad |
| Baltimore and Ohio Railroad | B&O, BO | B&O | 1874 | 1987 | Chesapeake and Ohio Railway |
| Baltimore and Ohio and Chicago Railroad | | B&O | 1876 | 1949 | Baltimore and Ohio Railroad |
| Baltimore and Ohio Southwestern Railroad | | B&O | 1899 | 1949 | Baltimore and Ohio Railroad |
| Baltimore and Ohio Southwestern Railway | | B&O | 1893 | 1899 | Cincinnati, Louisville and Vincennes Railway |
| Baltimore, Pittsburgh and Chicago Railway | | B&O | 1872 | 1876 | Baltimore and Ohio and Chicago Railroad |
| Bedford Belt Railway | | MILW | 1892 | 1910 | Chicago, Terre Haute and Southeastern Railway |
| Bedford and Bloomfield Railroad | | MON | 1883 | 1897 | Chicago, Indianapolis and Louisville Railway |
| Bedford, Springville, Owensburg and Bloomfield Railroad | | MON | 1874 | 1883 | Bedford and Bloomfield Railroad |
| Bedford Stone Railway | | | 1901 | 1917 | N/A |
| Bedford and Wallner Railroad | | MON | 1905 | 1927 | Chicago, Indianapolis and Louisville Railway |
| Bellefontaine Railway | | NYC | 1864 | 1868 | Cleveland, Columbus, Cincinnati and Indianapolis Railway |
| Belt Railroad of Indianapolis | | NYC/ PRR | 1877 | 1881 | Belt Railroad and Stockyard Company |
| Belt Railroad and Stockyard Company | | NYC/ PRR | 1881 | 1883 | Belt Railroad and Stock Yards Company |
| Belt Railroad and Stock Yards Company | | NYC/ PRR | 1883 | | |
| Benton Central Railroad | | | 1987 | 1989 | Kankakee, Beaverville and Southern Railroad |
| Bloomfield Railroad | | IC, MON | 1874 | 1886 | Bedford and Bloomfield Railroad, Indiana and Illinois Southern Railroad |
| Bloomington Southern Railroad | | IC | 1906 | 1946 | Illinois Central Railroad |
| Bluffton, Kokomo and Southwestern Railroad | | NKP | 1886 | 1886 | Toledo, St. Louis and Kansas City Railroad |
| Borinstein Railroad | BRRC | | 1985 | early 1990s | N/A |
| Buffalo and Mississippi Railroad | | NYC | 1835 | 1837 | Northern Indiana Railroad |
| Butler and Detroit Railroad | | WAB | 1880 | 1881 | Detroit, Butler and St. Louis Railroad |
| Cairo and Vincennes Railroad | | NYC | 1872 | 1880 | Cairo and Vincennes Railway |
| Cairo and Vincennes Railway | | NYC | 1880 | 1881 | Wabash, St. Louis and Pacific Railway |
| Cairo, Vincennes and Chicago Railway | | NYC | 1889 | 1913 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Calumet River Railway | | B&O | 1886 | 1887 | Chicago and Calumet Terminal Railway |
| Canada and St. Louis Railway | | NYC | 1887 | 1889 | Sturgis, Goshen and St. Louis Railway |
| Carthage, Knightstown and Shirley Railroad | CKSI | | 1987 | 1988 | N/A | Continued as a tourist railroad |
| Central Indiana Railway | CIND | NYC/ PRR | 1903 | 1976 | Consolidated Rail Corporation |
| Central Railroad of Indianapolis | | NYC | 1899 | | N/A |
| Chesapeake and Ohio Railway | C&O, CO | C&O | 1921 | 1987 | CSX Transportation |
| Chesapeake and Ohio Railway of Indiana | | C&O | 1910 | 1934 | Chesapeake and Ohio Railway |
| Chicago and Atlantic Railway | | ERIE | 1873 | 1890 | Chicago and Erie Railroad |
| Chicago, Attica and Southern Railroad | | | 1922 | 1946 | N/A |
| Chicago and Block Coal Railroad | | C&EI | 1879 | 1883 | Chicago and Great Southern Railway |
| Chicago and Calumet Terminal Railway | | B&O | 1887 | 1898 | Chicago Terminal Transfer Railroad |
| Chicago and Canada Southern Railway | | | 1871 | 1888 | N/A | Sold at foreclosure; no property in Indiana |
| Chicago and Cincinnati Railroad | | C&O | 1902 | 1902 | Chicago, Cincinnati and Louisville Railroad |
| Chicago and Cincinnati Railroad | | PRR | 1857 | 1865 | Chicago and Great Eastern Railway |
| Chicago, Cincinnati and Louisville Railroad | | C&O | 1903 | 1910 | Chesapeake and Ohio Railway of Indiana |
| Chicago, Cincinnati and Louisville Railroad | | NKP | 1866 | 1886 | Lake Erie and Western Railroad |
| Chicago, Continental and Baltimore Railway | | ERIE | 1871 | 1873 | Chicago and Atlantic Railway |
| Chicago, Danville and Vincennes Railroad | | C&EI | 1872 | 1877 | State Line and Covington Railroad |
| Chicago and Dyer Railroad | | MON | 1880 | 1880 | Chicago and Indianapolis Air Line Railway |
| Chicago and Eastern Illinois Railroad | C&EI, CEI | C&EI | 1940 | 1969 | Louisville and Nashville Railroad |
| Chicago and Eastern Illinois Railroad | | C&EI | 1877 | 1922 | Chicago and Eastern Illinois Railway |
| Chicago and Eastern Illinois Railway | | C&EI | 1922 | 1940 | Chicago and Eastern Illinois Railroad |
| Chicago and Erie Railroad | | ERIE | 1890 | 1941 | Erie Railroad |
| Chicago and Grand Trunk Railway | | GTW | 1880 | 1900 | Indiana and Illinois Railway |
| Chicago and Great Eastern Railway | | PRR | 1863 | 1868 | Columbus, Chicago and Indiana Central Railway |
| Chicago and Great Southern Railway | | C&EI | 1881 | 1886 | Indiana Railway |
| Chicago, Hammond and Western Railroad | | NYC | 1896 | 1898 | Chicago Junction Railway |
| Chicago Heights and Northern Railway | | EJE | 1897 | 1897 | Elgin, Joliet and Eastern Railway |
| Chicago and Indiana Railroad | CINR | | 1979 | 1979 | Tippecanoe Railroad |
| Chicago and Indiana Coal Railway | | C&EI | 1885 | 1894 | Chicago and Eastern Illinois Railroad |
| Chicago, Indiana and Eastern Railway | | PRR | 1893 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Chicago, Indiana and Southern Railroad | | NYC | 1906 | 1914 | New York Central Railroad |
| Chicago and Indianapolis Air Line Railway | | MON | 1880 | 1881 | Louisville, New Albany and Chicago Railway |
| Chicago, Indianapolis and Louisville Railway | CI&L, CIL | MON | 1897 | 1956 | Monon Railroad |
| Chicago and Indianapolis Terminal Company | | MON | 1896 | 1897 | Chicago, Indianapolis and Louisville Railway |
| Chicago Junction Railway | | NYC | 1898 | 1907 | Indiana Harbor Belt Railroad |
| Chicago and Lake Huron Railroad | | GTW | 1873 | 1879 | Indiana Railway |
| Chicago, Lake Shore and Eastern Railway | | EJE | 1895 | 1938 | Elgin, Joliet and Eastern Railway |
| Chicago, Milwaukee and St. Paul Railway | | MILW | 1921 | 1928 | Chicago, Milwaukee, St. Paul and Pacific Railroad |
| Chicago, Milwaukee, St. Paul and Pacific Railroad | MILW | MILW | 1928 | 1985 | The Milwaukee Road, Inc. |
| Chicago, St. Louis and New Orleans Railroad | | IC | 1898 | 1951 | Illinois Central Railroad |
| Chicago, St. Louis and Pittsburgh Railroad | | PRR | 1883 | 1890 | Pittsburgh, Cincinnati, Chicago and St. Louis Railway |
| Chicago and South Eastern Railway | | NYC/ PRR | 1891 | 1903 | Central Indiana Railway |
| Chicago South Shore and South Bend Railroad | CSS | | 1925 | | | Electric until 1981 |
| Chicago and State Line Extension Railway | | GTW | 1879 | 1879 | North Western Grand Trunk Railway |
| Chicago Terminal Transfer Railroad | | B&O | 1897 | 1910 | Baltimore and Ohio Chicago Terminal Railroad |
| Chicago, Terre Haute and Southeastern Railway | CTSE | MILW | 1910 | 1948 | Chicago, Milwaukee, St. Paul and Pacific Railroad |
| Chicago and Wabash Valley Railroad | | MON | 1898 | 1900 | Chicago and Wabash Valley Railway |
| Chicago and Wabash Valley Railway | | MON | 1900 | 1916 | Chicago, Indianapolis and Louisville Railway |
| Chicago and West Michigan Railway | | PM | 1881 | 1917 | Pere Marquette Railroad |
| Cincinnati and Bedford Railway | | B&O | 1889 | 1893 | Baltimore and Ohio Southwestern Railway |
| Cincinnati, Bluffton and Chicago Railroad | | | 1903 | 1917 | N/A |
| Cincinnati, Cambridge and Chicago Short Line Railway | | NKP | 1853 | 1854 | Cincinnati and Chicago Railroad |
| Cincinnati and Chicago Railroad | | NKP, PRR | 1854 | 1860 | Cincinnati and Chicago Air-Line Railroad, Cincinnati, Connersville and Muncie Railroad, Connersville and New Castle Junction Railroad |
| Cincinnati and Chicago Air-Line Railroad | | PRR | 1860 | 1865 | Chicago and Great Eastern Railway |
| Cincinnati, Connersville and Muncie Railroad | | NKP | 1868 | 1869 | Fort Wayne, Muncie and Cincinnati Railroad |
| Cincinnati, Findlay and Fort Wayne Railway | | | 1903 | 1919 | N/A |
| Cincinnati and Fort Wayne Railroad | | PRR | 1853 | 1866 | Cincinnati, Richmond and Fort Wayne Railroad |
| Cincinnati, Hamilton and Dayton Railway | | B&O | 1895 | 1917 | Baltimore and Ohio Railroad | Leased the Cincinnati, Findlay and Fort Wayne Railway and Cincinnati, Indianapolis and Western Railway |
| Cincinnati, Hamilton and Indianapolis Railroad | | B&O | 1872 | 1902 | Cincinnati, Indianapolis and Western Railway |
| Cincinnati, Indianapolis, St. Louis and Chicago Railway | | NYC | 1880 | 1889 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati, Indianapolis and Western Railroad | CIWN | B&O | 1915 | 1990 | CSX Transportation |
| Cincinnati, Indianapolis and Western Railway | | B&O | 1902 | 1915 | Cincinnati, Indianapolis and Western Railroad |
| Cincinnati, Lafayette and Chicago Railroad | | NYC | 1870 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati, Logansport and Chicago Railway | | PRR | 1853 | 1854 | Cincinnati and Chicago Railroad |
| Cincinnati, Louisville and Vincennes Railway | | B&O | 1899 | 1899 | Baltimore and Ohio Southwestern Railroad |
| Cincinnati and Martinsville Railroad | | NYC | 1865 | 1877 | Fairland, Franklin and Martinsville Railroad |
| Cincinnati, New Castle and Michigan Railroad | | NKP | 1853 | 1854 | Cincinnati and Chicago Railroad |
| Cincinnati, Peru and Chicago Railway | | NKP | 1853 | 1865 | Chicago, Cincinnati and Louisville Railroad |
| Cincinnati and Richmond Railroad | | PRR | 1890 | 1890 | Pittsburgh, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati, Richmond and Fort Wayne Railroad | | PRR | 1866 | 1927 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Cincinnati, Richmond and Muncie Railroad | | C&O | 1900 | 1903 | Chicago, Cincinnati and Louisville Railroad |
| Cincinnati, Rockport and Southwestern Railway | | SOU | 1872 | 1880 | Evansville, Rockport and Eastern Railway |
| Cincinnati and Southern Ohio River Railway | | NYC | 1887 | 1915 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cincinnati and Southwestern Railway | | SOU | 1871 | 1872 | Cincinnati, Rockport and Southwestern Railway |
| Cincinnati and Terre Haute Railway | | NYC | 1871 | 1877 | Columbus, Hope and Greensburg Railroad, Terre Haute and Southeastern Railroad |
| Cincinnati, Wabash and Michigan Railway | | NYC | 1871 | 1915 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cleveland, Cincinnati, Chicago and St. Louis Railway | | NYC | 1889 | 1976 | Consolidated Rail Corporation |
| Cleveland, Columbus, Cincinnati and Indianapolis Railway | | NYC | 1868 | 1889 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Cleveland, Fort Wayne and Chicago Railroad | | NKP | 1865 | 1879 | Ohio Railway |
| Cleveland, Indiana and St. Louis Railway | | NYC/ PRR | 1882 | 1885 | Midland Railway |
| Columbus, Chicago and Indiana Central Railway | | PRR | 1868 | 1883 | Chicago, St. Louis and Pittsburgh Railroad |
| Columbus, Hope and Greensburg Railroad | | NYC | 1882 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Columbus and Indiana Central Railway | | PRR | 1867 | 1868 | Columbus, Chicago and Indiana Central Railway |
| Columbus and Indianapolis Central Railway | | PRR | 1864 | 1867 | Columbus and Indiana Central Railway |
| Columbus and Shelby Railroad | | PRR | 1852 | 1881 | Jeffersonville, Madison and Indianapolis Railroad |
| Connersville and New Castle Junction Railroad | | NKP | 1863 | 1868 | Cincinnati, Connersville and Muncie Railroad |
| Consolidated Rail Corporation | CR | | 1976 | 1999 | CSX Transportation, Norfolk Southern Railway |
| Cook Transit Company | | | 1947 | 1956 | N/A |
| Crawfordsville and Rockville Railroad | | PRR | 1869 | 1871 | Logansport, Crawfordsville and South Western Railway |
| Crawfordsville and Wabash Railroad | | MON | 1846 | 1852 | New Albany and Salem Railroad |
| Dayton and Chicago Railway | | | 1886 | 1887 | Dayton, Fort Wayne and Chicago Railway |
| Dayton, Fort Wayne and Chicago Railway | | | 1887 | 1891 | N/A | Sold at foreclosure; no property in Indiana |
| Dayton and Union Railroad | | B&O | 1863 | 1989 | CSX Transportation |
| Decatur and Ohio Railway | | | 1886 | 1886 | Dayton and Chicago Railway |
| Delphos, Bluffton and Frankfort Railroad | | NKP | 1877 | 1879 | Toledo, Delphos and Burlington Railroad |
| Detroit, Butler and St. Louis Railroad | | WAB | 1881 | 1881 | Wabash, St. Louis and Pacific Railway |
| Detroit, Eel River and Illinois Railroad | | PRR | 1868 | 1877 | Eel River Railroad |
| Detroit, Logansport and St. Louis Railroad | | PRR | 1869 | 1870 | Detroit, Eel River and Illinois Railroad |
| Dinwiddie and Gary Railway | | MON | | 1909 | Chicago and Wabash Valley Railway |
| East Chicago Belt Railroad | | NYC | 1896 | 1907 | Indiana Harbor Belt Railroad |
| Eaton and Hamilton Railroad | | PRR | 1854 | 1862 | Richmond and Miami Railway |
| Eel River Railroad | | PRR | 1877 | 1897 | Logansport and Toledo Railway |
| Elkhart and Western Railroad | | NYC | 1888 | 1915 | New York Central Railroad |
| Elwood, Anderson and Lapelle Railroad | | | 1897 | 1929 | N/A |
| Erie Railroad | ERIE | ERIE | 1941 | 1960 | Erie–Lackawanna Railroad |
| Erie–Lackawanna Railroad | EL | | 1960 | 1968 | Erie Lackawanna Railway |
| Erie Lackawanna Railway | EL | | 1968 | 1976 | Consolidated Rail Corporation |
| Erie Western Railway | ERES | | 1977 | 1979 | Chicago and Indiana Railroad |
| Evansville Railways Company | | | 1909 | 1919 | Evansville and Ohio Valley Railway | Operated electric passenger and steam freight trains |
| Evansville Belt Railway | | C&EI | 1881 | 1911 | Chicago and Eastern Illinois Railroad |
| Evansville, Carmi and Paducah Railroad | | L&N | 1869 | 1871 | St. Louis and Southeastern Railway |
| Evansville and Crawfordsville Railroad | | C&EI | 1853 | 1877 | Evansville and Terre Haute Railroad |
| Evansville and Eastern Electric Railway | | | 1904 | 1909 | Evansville Railways Company | Operated electric passenger and steam freight trains |
| Evansville and Illinois Railroad | | C&EI | 1849 | 1853 | Evansville and Crawfordsville Railroad |
| Evansville and Indianapolis Railroad | E&I | NYC | 1869 | 1920 | Evansville, Indianapolis and Terre Haute Railway |
| Evansville, Indianapolis and Cleveland Straight Line Railroad | | NYC | 1853 | 1869 | Evansville and Indianapolis Railroad |
| Evansville, Indianapolis and Terre Haute Railway | | NYC | 1920 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Evansville Local Trade Railroad | | SOU | 1879 | 1880 | Evansville, Rockport and Eastern Railway |
| Evansville, Mount Carmel and Northern Railway | | NYC | 1906 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Evansville and New Harmony Railway | | IC | 1881 | 1903 | Illinois Central Railroad |
| Evansville and Ohio Valley Railway | | | 1918 | 1946 | N/A | Operated electric passenger and steam freight trains |
| Evansville, Owensboro and Nashville Railroad | | | 1873 | 1877 | N/A | Sold at foreclosure; no property in Indiana |
| Evansville and Peoria Railway | | IC | 1880 | 1880 | Peoria, Decatur and Evansville Railway |
| Evansville and Richmond Railroad | | MILW | 1886 | 1897 | Evansville and Richmond Railway |
| Evansville and Richmond Railway | | MILW | 1897 | 1897 | Southern Indiana Railway |
| Evansville, Rockport and Eastern Railway | | SOU | 1880 | 1881 | Louisville, New Albany and St. Louis Railway |
| Evansville Suburban and Newburgh Railway | | | 1888 | 1947 | Cook Transit Company | Operated electric passenger and steam freight trains |
| Evansville Terminal Company | EVT | | 1996 | 2000 | Indiana Southwestern Railway |
| Evansville Terminal Railway | | | 1908 | 1909 | Evansville Railways Company | Operated electric passenger and steam freight trains |
| Evansville and Terre Haute Railroad | | C&EI | 1877 | 1911 | Chicago and Eastern Illinois Railroad |
| Evansville, Terre Haute and Chicago Railway | | C&EI | 1869 | 1899 | Chicago and Eastern Illinois Railroad |
| Evansville, Washington and Brazil Railroad | | NYC | 1883 | 1885 | Evansville and Indianapolis Railroad |
| Evansville, Washington and Worthington Railroad | | NYC | 1878 | 1880 | Indianapolis and Evansville Railroad |
| Fairland, Franklin and Martinsville Railroad | | NYC | 1877 | 1915 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Ferdinand Railroad | FRDN | | 1911 | 1987 | Ferdinand and Huntingburg Railroad |
| Ferdinand Railway | | | 1906 | 1911 | Ferdinand Railroad |
| Ferdinand and Huntingburg Railroad | FHRR | | 1987 | 1991 | N/A |
| Findlay, Fort Wayne and Western Railroad | | | 1890 | 1894 | Fort Wayne and Eastern Railway |
| Findlay, Fort Wayne and Western Railway | | | 1894 | 1903 | Cincinnati, Findlay and Fort Wayne Railway |
| Fort Wayne and Chicago Railroad | | PRR | 1852 | 1856 | Pittsburgh, Fort Wayne and Chicago Railroad |
| Fort Wayne, Cincinnati and Louisville Railroad | | NKP | 1881 | 1890 | Lake Erie and Western Railroad |
| Fort Wayne and Detroit Railroad | | WAB | 1901 | 1901 | Wabash Railroad |
| Fort Wayne and Eastern Railway | | | 1894 | 1894 | Findlay, Fort Wayne and Western Railway |
| Fort Wayne and Findlay Railroad | | | 1890 | 1890 | Findlay, Fort Wayne and Western Railroad |
| Fort Wayne and Illinois Railroad | | NKP | 1887 | 1887 | New York, Chicago and St. Louis Railroad |
| Fort Wayne and Jackson Railroad | | NYC | 1880 | 1976 | Consolidated Rail Corporation, Hillsdale County Railway |
| Fort Wayne, Jackson and Saginaw Railroad | | NYC | 1868 | 1879 | Fort Wayne and Jackson Railroad |
| Fort Wayne, Muncie and Cincinnati Railroad | | NKP | 1869 | 1881 | Fort Wayne, Cincinnati and Louisville Railroad |
| Fort Wayne, Muncie and Cincinnati Railway | | NKP | 1868 | 1869 | Fort Wayne, Muncie and Cincinnati Railroad |
| Fort Wayne and Southern Railroad | | B&O, NKP | 1849 | 1868 | Fort Wayne, Muncie and Cincinnati Railway, Ohio and Mississippi Railway |
| Fort Wayne, Terre Haute and Southwestern Railroad | | NYC/ PRR | 1890 | 1901 | Chicago and South Eastern Railway |
| Fort Wayne Union Railway | FWU | NKP/ NYC/ PRR/ WAB | 1922 | | |
| Frankfort and Crawfordsville Railroad | | PRR | 1869 | 1871 | Logansport, Crawfordsville and South Western Railway |
| Frankfort and Kokomo Railroad | | NKP | 1870 | 1881 | Toledo, Cincinnati and St. Louis Railroad |
| Frankfort and State Line Railroad | | NKP | 1879 | 1881 [1] | Toledo, Cincinnati and St. Louis Railroad |
| Frankfort, St. Louis and Toledo Railroad | | NKP | 1876 | 1882 | Toledo, Cincinnati and St. Louis Railroad |
| Franklin and Martinsville Railroad | | NYC | 1859 | 1865 | Cincinnati and Martinsville Railroad |
| Fulton County Railroad | | | 1981 | 1985 | N/A |
| Gary and Western Railway | | NYC | 1906 | 1928 | New York Central Railroad |
| Grand Rapids and Fort Wayne Railroad | | PRR | 1857 | 1857 | Grand Rapids and Indiana Railroad |
| Grand Rapids and Indiana Railroad | | PRR | 1854 | 1896 | Grand Rapids and Indiana Railway |
| Grand Rapids and Indiana Railway | | PRR | 1896 | 1954 | Penndel Company |
| Grand Rapids, Wabash and Cincinnati Railroad | | NYC | 1869 | 1871 | Cincinnati, Wabash and Michigan Railway |
| Grand Trunk Railway of Northern Indiana | | NYC | 1868 | 1868 | Michigan Air Line Railroad |
| Grand Trunk Western Railway | | GTW | 1900 | 1928 | Grand Trunk Western Railroad |
| Greenville and Miami Railroad | | B&O | 1846 | 1862 | Dayton and Union Railroad |
| Griffith and Northern Railway | | EJE | 1899 | 1931 | Elgin, Joliet and Eastern Railway |
| Hammond Belt Railway | | C&O | 1906 | | N/A |
| Hammond and Blue Island Railroad | | NYC | 1895 | 1896 | Chicago, Hammond and Western Railroad |
| Hammond and Lake Michigan Railway | | B&O | 1887 | 1887 | Chicago and Calumet Terminal Railway |
| Havana, Rantoul and Eastern Railroad | | IC | 1878 | 1887 | Lebanon and Western Railroad |
| Henderson Bridge Company | | L&N | 1881 | 1906 | Henderson Bridge and Railroad Company |
| Henderson Bridge and Railroad Company | | L&N | 1906 | 1906 | Louisville and Nashville Railroad |
| Hillsdale County Railway | HCRC | | 1976 | 1992 | Indiana Northeastern Railroad |
| Hope and Greensburg Railroad | | NYC | 1880 | 1882 | Columbus, Hope and Greensburg Railroad |
| Huntingburg, Tell City and Cannelton Railroad | | SOU | 1885 | 1889 | Louisville, Evansville and St. Louis Consolidated Railroad |
| Indiana Block Coal Railroad | | C&EI | 1878 | 1899 | Chicago and Eastern Illinois Railroad |
| Illinois Central Railroad | IC | IC | 1886 | 1972 | Illinois Central Gulf Railroad |
| Illinois Central Gulf Railroad | ICG | | 1972 | 1986 | Indiana Rail Road, Indiana Hi-Rail Corporation |
| Illinois and Indiana Railroad | | IC | 1899 | 1906 | Indianapolis Southern Railroad |
| Indiana Railway | | NYC | 1887 | 1887 | Indiana and Western Railway |
| Indiana Railway | | C&EI | 1886 | 1886 | Chicago and Indiana Coal Railway |
| Indiana Railway | | GTW | 1880 | 1880 | Chicago and Grand Trunk Railway |
| Indiana, Bloomington and Western Railway | | NYC | 1879 | 1887 | Indiana Railway |
| Indiana Central Railway | | PRR | 1848 | 1864 | Columbus and Indianapolis Central Railway |
| Indiana and Chicago Railway | | C&EI | 1880 | 1881 | Chicago and Great Southern Railway |
| Indiana, Decatur and Western Railway | | B&O | 1894 | 1902 | Cincinnati, Indianapolis and Western Railway |
| Indiana Eastern Railroad and Transportation Company | | | 1979 | 1984 | Indiana Midland Railway |
| Indiana Harbor Railroad | | NYC | 1901 | 1906 | Chicago, Indiana and Southern Railroad |
| Indiana Hi-Rail Corporation | IHRC | | 1980 | 1997 | C&NC Railroad, CSX Transportation, Evansville Terminal Company, Fulton County Railroad, Hoosier Southern Railroad, Maumee and Western Railroad, Wabash Central Railroad |
| Indiana and Illinois Railway | | GTW | 1900 | 1900 | Grand Trunk Western Railway |
| Indiana and Illinois Central Railway | | B&O | 1853 | 1875 | Indianapolis, Decatur and Springfield Railway |
| Indiana, Illinois and Iowa Railroad | | NYC | 1881 | 1906 | Chicago, Indiana and Southern Railroad |
| Indiana, Illinois and Iowa Railway | | NYC | 1893 | 1898 | Indiana, Illinois and Iowa Railroad |
| Indiana and Illinois Southern Railroad | | IC | 1886 | 1890 | St. Louis, Indianapolis and Eastern Railroad |
| Indiana Interstate Railway | IIRC | | 1978 | 1980 | N/A |
| Indiana and Lake Michigan Railway | | NYC | 1887 | 1898 | St. Joseph, South Bend and Southern Railroad |
| Indiana Midland Railway | IMID | | 1985 | 1987 | Carthage, Knightstown and Shirley Railroad |
| Indiana North and South Railroad | | C&EI | 1869 | 1879 | Chicago and Block Coal Railroad |
| Indiana Northern Railway | | WAB | 1891 | 1959 | New Jersey, Indiana and Illinois Railroad |
| Indiana and Ohio Railroad | INOH | | 1979 | 1997 | Indiana and Ohio Railway |
| Indiana Southern Railway | | B&O, NKP | 1866 | 1880 | Fort Wayne, Cincinnati and Louisville Railroad, Ohio and Mississippi Railway |
| Indiana and Southwestern Railway | | NYC | 1886 | 1887 | Canada and St. Louis Railway |
| Indiana and Western Railroad | | IC | 1899 | 1899 | Illinois and Indiana Railroad |
| Indiana Transportation Museum | ITMZ | | 1960 | 2023 | Nickel Plate Express |
| Indiana Stone Railroad | | MON | 1898 | 1916 | Chicago, Indianapolis and Louisville Railway |
| Indiana and Western Railway | | NYC | 1887 | 1887 | Ohio, Indiana and Western Railway |
| Indianapolis and Bellefontaine Railroad | | NYC | 1848 | 1855 | Indianapolis, Pittsburgh and Cleveland Railroad |
| Indianapolis, Bloomington and Western Railway | | NYC | 1869 | 1879 | Indianapolis and Danville Railroad |
| Indianapolis and Cincinnati Railroad | | NYC | 1853 | 1867 | Indianapolis, Cincinnati and La Fayette Railway |
| Indianapolis, Cincinnati and La Fayette Railroad | | NYC | 1873 | 1880 | Cincinnati, Indianapolis, St. Louis and Chicago Railway |
| Indianapolis, Cincinnati and La Fayette Railway | | NYC | 1867 | 1873 | Indianapolis, Cincinnati and La Fayette Railroad |
| Indianapolis, Crawfordsville and Danville Railroad | | NYC | 1868 | 1869 | Indianapolis, Bloomington and Western Railway |
| Indianapolis and Danville Railroad | | NYC | 1879 | 1879 | Indiana, Bloomington and Western Railway |
| Indianapolis, Decatur and Springfield Railway | | B&O | 1875 | 1887 | Indianapolis and Wabash Railway |
| Indianapolis, Decatur and Western Railway | | B&O | 1888 | 1894 | Indiana, Decatur and Western Railway |
| Indianapolis, Delphi and Chicago Railroad | | MON | 1872 | 1881 | Chicago and Indianapolis Air Line Railway |
| Indianapolis and Evansville Railroad | | NYC | 1880 | 1884 | Evansville and Indianapolis Railroad |
| Indianapolis and Louisville Railway | | MON | 1899 | 1916 | Chicago, Indianapolis and Louisville Railway |
| Indianapolis and Madison Railroad | | PRR | 1862 | 1866 | Jeffersonville, Madison and Indianapolis Railroad |
| Indianapolis and Ohio State Line Railway | | NYC | 1880 | 1881 | Ohio, Indiana and Pacific Railway |
| Indianapolis, Peru and Chicago Railway | | NKP | 1864 | 1887 | Lake Erie and Western Railroad |
| Indianapolis, Pittsburgh and Cleveland Railroad | | NYC | 1855 | 1864 | Cleveland, Columbus, Cincinnati and Indianapolis Railway |
| Indianapolis, Rochester and Chicago Railroad | | NKP | 1863 | 1867 | Chicago, Cincinnati and Louisville Railroad |
| Indianapolis and St. Louis Railroad | | NYC | 1867 | 1882 | Indianapolis and St. Louis Railway |
| Indianapolis and St. Louis Railway | | NYC | 1882 | 1889 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Indianapolis and Sandusky Railroad | | NKP | 1877 | 1879 | Lake Erie and Western Railway |
| Indianapolis Southern Railroad | | IC | 1906 | 1911 | Illinois Central Railroad |
| Indianapolis Southern Railway | | IC | 1899 | 1906 | Indianapolis Southern Railroad |
| Indianapolis Union Railway | IU | NYC/ PRR | 1853 | 1976 | Consolidated Rail Corporation |
| Indianapolis and Vincennes Railroad | | PRR | 1865 | 1905 | Vandalia Railroad |
| Indianapolis and Wabash Railway | | B&O | 1887 | 1888 | Indianapolis, Decatur and Western Railway |
| Jeffersonville Railroad | | PRR | 1849 | 1866 | Jeffersonville, Madison and Indianapolis Railroad |
| Jeffersonville, Madison and Indianapolis Railroad | | PRR | 1866 | 1890 | Vandalia Railroad |
| J.K. Line, Inc. | JKL | | 1990 | 2002 | N/A |
| Joliet and Northern Indiana Railroad | | NYC | 1854 | 1976 | Consolidated Rail Corporation |
| Junction Railroad | | B&O | 1848 | 1878 | Cincinnati, Hamilton and Indianapolis Railroad |
| Kentucky and Indiana Bridge Company | | B&O/ MON/ SOU | 1881 | 1900 | Kentucky and Indiana Bridge and Railroad Company |
| Kentucky and Indiana Bridge and Railroad Company | | B&O/ MON/ SOU | 1900 | 1910 | Kentucky and Indiana Terminal Railroad |
| Kentucky and Indiana Terminal Railroad | KIT | B&O/ MON/ SOU | 1910 | 1981 | Southern Railway |
| Kingan Railroad | | | 1873 | 1901 | White River Railway |
| Knightstown and Shelbyville Railroad | | | 1846 | 1854 | N/A |
| Kokomo Belt Railroad | | PRR | 1888 | 1890 | Chicago, St. Louis and Pittsburgh Railroad |
| Kokomo and Marion Railroad | | NKP | 1875 | 1876 | Frankfort, St. Louis and Toledo Railroad |
| LaFayette, Bloomington and Muncie Railway | | NKP | 1879 | 1879 | Lake Erie and Western Railway |
| Lafayette and Indianapolis Railroad | | NYC | 1846 | 1867 | Indianapolis, Cincinnati and La Fayette Railway |
| La Fayette and Monon Railway | | MON | 1892 | 1897 | Chicago, Indianapolis and Louisville Railway |
| LaFayette, Muncie and Bloomington Railroad | | NKP | 1869 | 1879 | Muncie and State Line Railroad |
| La Fayette Union Railway | | WAB | 1890 | | |
| LaGrange, Toledo and Eastern Railway | | | 1918 | 1920 | N/A |
| Lake Erie, Evansville and South Western Railway | | SOU | 1880 | 1880 | Evansville Local Trade Railroad |
| Lake Erie, Evansville and Southwestern Railway | | SOU | 1871 | 1877 | Evansville Local Trade Railroad |
| Lake Erie and Fort Wayne Railroad | LEFW | | 1904 | 1982 | Norfolk and Western Railway |
| Lake Erie and Louisville Railroad | | PRR | 1865 | 1890 | Jeffersonville, Madison and Indianapolis Railroad |
| Lake Erie and Louisville Railway | | | 1871 | 1877 | N/A | Sold at foreclosure; no property in Indiana |
| Lake Erie and Pacific Railroad | | PRR | 1860 | 1865 | Lake Erie and Louisville Railroad |
| Lake Erie, Wabash and St. Louis Railroad | | WAB | 1852 | 1856 | Toledo, Wabash and Western Railroad |
| Lake Erie and Western Railroad | | NKP | 1887 | 1923 | New York, Chicago and St. Louis Railroad |
| Lake Erie and Western Railway | | NKP | 1879 | 1886 | Lake Erie and Western Railroad |
| Lake Michigan and Ohio River Railway | | C&EI | 1885 | 1885 | Chicago and Indiana Coal Railway |
| Lake Shore and Michigan Southern Railway | | NYC | 1869 | 1914 | New York Central Railroad |
| Lawrenceburg and Upper Mississippi Railroad | | NYC | 1850 | 1853 | Indianapolis and Cincinnati Railroad |
| Lebanon and Western Railroad | | IC | 1887 | 1887 | Rantoul Railroad |
| Logansport, Camden and Frankfort Railroad | | PRR | 1869 | 1871 | Logansport, Crawfordsville and South Western Railway |
| Logansport, Crawfordsville and South Western Railway | | PRR | 1871 | 1879 | Terre Haute and Logansport Railroad |
| Logansport and Northern Indiana Railroad | | PRR | 1853 | 1863 | Toledo, Logansport and Northern Indiana Railroad |
| Logansport and Pacific Railroad | | PRR | 1853 | 1853 | Logansport and Pacific Railway |
| Logansport and Pacific Railway | | PRR | 1853 | 1854 | Logansport, Peoria and Burlington Railway |
| Logansport, Peoria and Burlington Railway | | PRR | 1854 | 1858 | Toledo, Logansport and Burlington Railroad |
| Logansport and Toledo Railway | | PRR | 1901 | 1905 | Vandalia Railroad |
| Louisville Bridge Company | | PRR | 1856 | 1918 | Louisville Bridge and Railroad Company |
| Louisville Bridge and Railroad Company | | PRR | 1918 | 1918 | Louisville Bridge and Terminal Railway |
| Louisville Bridge and Terminal Railway | | PRR | 1918 | 1954 | Penndel Company |
| Louisville, Evansville and St. Louis Railroad | | SOU | 1886 | 1889 | Louisville, Evansville and St. Louis Consolidated Railroad |
| Louisville, Evansville and St. Louis Railway | | SOU | 1882 | 1886 | Louisville, Evansville and St. Louis Railroad |
| Louisville, Evansville and St. Louis Consolidated Railroad | | SOU | 1889 | 1900 | Southern Railway of Indiana |
| Louisville and Jeffersonville Bridge Company | | NYC | 1887 | 1917 | Louisville and Jeffersonville Bridge and Railroad Company |
| Louisville and Jeffersonville Bridge and Railroad Company | | NYC | 1917 | 1968 | N/A (owned by New York Central Railroad) |
| Louisville and Nashville Railroad | L&N, LN | L&N | 1880 | 1983 | Seaboard System Railroad |
| Louisville, New Albany and Chicago Railroad | | MON | 1859 | 1873 | Louisville, New Albany and Chicago Railway |
| Louisville, New Albany and Chicago Railway | | MON | 1873 | 1897 | Chicago, Indianapolis and Louisville Railway |
| Louisville, New Albany and Corydon Railroad | | | 1887 | 2006 | Lucas Oil Rail Line |
| Louisville, New Albany and Corydon Railway | | | 1881 | 1887 | Louisville, New Albany and Corydon Railroad |
| Louisville, New Albany and St. Louis Railway | | SOU | 1877 | 1882 | Louisville, Evansville and St. Louis Railway |
| Louisville, New Albany and St. Louis Air Line Railway | | SOU | 1870 | 1877 | Louisville, New Albany and St. Louis Railway |
| Madison Railway | MDRY | | 1977 | 1978 | Madison Railroad |
| Madison and Indianapolis Railroad | | PRR | 1836 | 1862 | Indianapolis and Madison Railroad |
| Madison, Indianapolis and Peru Railroad | | NKP, PRR | 1854 | 1854 | Madison and Indianapolis Railroad, Peru and Indianapolis Railroad |
| Marion and Logansport Railroad | | PRR | 1853 | 1854 | Marion and Mississinewa Valley Railroad |
| Marion and Mississinewa Valley Railroad | | PRR | 1852 | 1863 | Union and Logansport Railroad |
| Marion and Ottawa Railroad | | NKP | 1875 | 1876 | Frankfort, St. Louis and Toledo Railroad |
| Martinsville and Franklin Railroad | | NYC | 1846 | 1859 | Franklin and Martinsville Railroad |
| Michigan Air Line Railroad | | NYC | 1868 | 1916 | Michigan Central Railroad |
| Michigan Central Railroad | MC | NYC | 1846 | 1976 | Consolidated Rail Corporation |
| Michigan City and Indianapolis Railroad | | NKP | 1870 | 1888 | Lake Erie and Western Railroad |
| Michigan Southern Railroad | MSO | | 1996 | 2001 | Elkhart and Western Railroad, Kendallville Terminal Railway |
| Michigan Southern and Northern Indiana Railroad | | NYC | 1855 | 1869 | Lake Shore and Michigan Southern Railway |
| Midland Railway | | NYC/ PRR | 1885 | 1891 | Chicago and South Eastern Railway |
| The Milwaukee Road, Inc. | MILW | | 1985 | 1986 | Soo Line Railroad |
| Mississippi and Atlantic Railway | | IC | 1875 | 1878 | Havana, Rantoul and Eastern Railroad |
| Monon Railroad | MON | MON | 1956 | 1971 | Louisville and Nashville Railroad |
| Montpelier and Chicago Railroad | | WAB | 1890 | 1891 | Wabash Railroad |
| Muncie Belt Railway | | NYC | 1892 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Muncie and State Line Railroad | | NKP | 1879 | 1879 | LaFayette, Bloomington and Muncie Railway |
| Muncie and Western Railroad | MWR | | 1902 | 1995 | N/A |
| New Albany and Eastern Railway | | B&O | 1887 | 1888 | Ohio and Mississippi Railway |
| New Albany and St. Louis Air Line Railway | | SOU | 1869 | 1870 | Louisville, New Albany and St. Louis Air Line Railway |
| New Albany and Salem Railroad | | MON | 1847 | 1859 | Louisville, New Albany and Chicago Railroad |
| New Castle and Danville Railroad | | NYC | 1854 | 1869 | Indianapolis, Crawfordsville and Danville Railroad |
| New Castle and Muncie Railroad | | NKP | 1867 | 1868 | Cincinnati, Connersville and Muncie Railroad |
| New Castle and Richmond Railroad | | PRR | 1848 | 1853 | Cincinnati, Logansport and Chicago Railway |
| New Castle and Rushville Railroad | | NKP | 1879 | 1886 | Fort Wayne, Cincinnati and Louisville Railroad |
| New Jersey, Indiana and Illinois Railroad | NJII | WAB | 1902 | 1983 | Norfolk and Western Railway |
| New York Central Railroad | NYC | NYC | 1914 | 1968 | Penn Central Transportation Company |
| New York and Chicago Railway | | NKP | 1881 | 1881 | New York, Chicago and St. Louis Railway |
| New York, Chicago and St. Louis Railroad | NKP | NKP | 1887 | 1964 | Norfolk and Western Railway |
| New York, Chicago and St. Louis Railway | | NKP | 1881 | 1887 | Fort Wayne and Illinois Railroad |
| New York, Fort Wayne and Chicago Railroad | | NKP | 1880 | 1881 | New York, Chicago and St. Louis Railway |
| Norfolk and Western Railway | N&W, NW | | 1964 | 1998 | Norfolk Southern Railway |
| North Western Grand Trunk Railway | | GTW | 1879 | 1880 | Chicago and Grand Trunk Railway |
| Northern Indiana Railroad | | NYC | 1837 | 1855 | Michigan Southern and Northern Indiana Railroad |
| Ohio Railway | | NKP | 1879 | 1880 | New York, Fort Wayne and Chicago Railroad |
| Ohio, Fort Wayne and Chicago Railroad | | NKP | 1880 | 1880 | New York, Fort Wayne and Chicago Railroad |
| Ohio and Indiana Railroad | | PRR | 1851 | 1856 | Pittsburgh, Fort Wayne and Chicago Railroad |
| Ohio, Indiana and Pacific Railway | | NYC | 1881 | 1881 | Indiana, Bloomington and Western Railway |
| Ohio, Indiana and Western Railway | | NYC | 1887 | 1890 | Cleveland, Cincinnati, Chicago and St. Louis Railway, Peoria and Eastern Railway |
| Ohio and Indianapolis Railroad | | B&O | 1853 | 1853 | Junction Railroad |
| Ohio and Indianapolis Railway | | PRR | 1832 | 1849 | Jeffersonville Railroad |
| Ohio and Mississippi Railroad | | B&O | 1848 | 1867 | Ohio and Mississippi Railway |
| Ohio and Mississippi Railway | | B&O | 1867 | 1893 | Baltimore and Ohio Southwestern Railway |
| Ohio Valley Railway | | IC | 1889 | 1897 | Chicago, St. Louis and New Orleans Railroad |
| Ohio Valley Railway and Terminal Company | | IC | 1888 | 1889 | Ohio Valley Railway |
| Orleans, Paoli and Jasper Railway | | MON | 1885 | 1887 | Orleans, West Baden and French Lick Springs Railway |
| Orleans, West Baden and French Lick Springs Railway | | MON | 1887 | 1897 | Chicago, Indianapolis and Louisville Railway |
| Pendleton and Indianapolis Railroad | | NYC | 1846 | 1848 | Indianapolis and Bellefontaine Railroad |
| Peninsular Railroad | | GTW | 1869 | 1870 | Peninsular Railway |
| Peninsular Railway | | GTW | 1870 | 1873 | Chicago and Lake Huron Railroad |
| Penn Central Transportation Company | PC | | 1968 | 1976 | Consolidated Rail Corporation |
| Penndel Company | | PRR | 1954 | 1976 | Consolidated Rail Corporation |
| Pennsylvania Company | | PRR | 1871 | 1918 | Pennsylvania Railroad |
| Pennsylvania Railroad | PRR | PRR | 1918 | 1968 | Penn Central Transportation Company |
| Peoria, Decatur and Evansville Railway | | IC | 1880 | 1900 | Illinois Central Railroad |
| Peoria and Eastern Railway | | NYC | 1890 | 1976 | Consolidated Rail Corporation |
| Pere Marquette Railroad | | PM | 1899 | 1917 | Pere Marquette Railway |
| Pere Marquette Railroad of Indiana | | PM | 1903 | 1907 | Pere Marquette Railroad |
| Pere Marquette Railway | PM | PM | 1917 | 1947 | Chesapeake and Ohio Railway |
| Peru and Detroit Railway | | WAB | 1889 | 1906 | Wabash Railroad, Winona Interurban Railway |
| Peru and Indianapolis Railroad | | NKP | 1846 | 1864 | Indianapolis, Peru and Chicago Railway |
| Philadelphia, Baltimore and Washington Railroad | | PRR | 1956 | 1976 | Consolidated Rail Corporation |
| Pigeon River Railroad | PGRV | | 1985 | | | Still exists as a lessor of Indiana Northeastern Railroad |
| Pittsburgh, Cincinnati, Chicago and St. Louis Railroad | | PRR | 1917 | 1956 | Philadelphia, Baltimore and Washington Railroad |
| Pittsburgh, Cincinnati, Chicago and St. Louis Railway | | PRR | 1890 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Pittsburgh, Fort Wayne and Chicago Railroad | | PRR | 1856 | 1861 | Pittsburgh, Fort Wayne and Chicago Railway |
| Pittsburgh, Fort Wayne and Chicago Railway | | PRR | 1862 | 1976 | Consolidated Rail Corporation |
| Plymouth, Kankakee and Pacific Railroad | | NYC | 1870 | 1881 | Indiana, Illinois and Iowa Railroad |
| Plymouth Short Line, Ltd. | PSLL | | 1985 | 1990 | N/A |
| Poseyville and Owensville Railroad | POR | | 1987 | 1996 | Owensville Terminal Company |
| Rantoul Railroad | | IC | 1887 | 1903 | Illinois Central Railroad |
| Richmond and Miami Railroad | | PRR | 1846 | 1854 | Eaton and Hamilton Railroad |
| Richmond and Miami Railway | | PRR | 1862 | 1890 | Cincinnati and Richmond Railroad |
| Rockport and Northern Central Railway | | SOU | 1869 | 1872 | Cincinnati, Rockport and Southwestern Railway |
| Rossville and Eastern Railroad | | C&EI | 1902 | 1903 | Chicago and Eastern Illinois Railroad |
| Rushville and Lawrenceburg Railroad | | NYC | 1848 | 1850 | Lawrenceburg and Upper Mississippi Railroad |
| Rushville and Shelbyville Railroad | | PRR | 1844 | 1859 | Shelby and Rush Railroad |
| St. Joseph, South Bend and Southern Railroad | | NYC | 1899 | 1943 | New York Central Railroad |
| St. Joseph Valley Railroad | | NYC | 1869 | 1870 | Michigan Air Line Railroad |
| St. Joseph Valley Railway | | | 1905 | 1918 | LaGrange, Toledo and Eastern Railway |
| St. Joseph Valley Traction Company | | | 1903 | 1918 | N/A |
| St. Louis, Alton and Terre Haute Railroad | | NYC | 1862 | 1890 | Cairo, Vincennes and Chicago Railway |
| St. Louis, Indianapolis and Eastern Railroad | | IC | 1889 | 1899 | Indiana and Western Railroad |
| St. Louis and South Eastern Railway | | L&N | 1872 | 1879 | South East and St. Louis Railway |
| St. Louis and Southeastern Railway | | L&N | 1871 | 1872 | St. Louis and South Eastern Railway |
| Seaboard System Railroad | SBD | | 1983 | 1986 | CSX Transportation |
| Shelby and Rush Railroad | | PRR | 1859 | 1882 | Jeffersonville, Madison and Indianapolis Railroad |
| South Chicago and Southern Railroad | | PRR | 1901 | 1954 | Penndel Company |
| South East and St. Louis Railway | | L&N | 1880 | 1936 | Louisville and Nashville Railroad |
| Southern Railway | SOU | SOU | 1900 | 1990 | Norfolk Southern Railway |
| Southern Railway of Indiana | | SOU | 1900 | 1944 | Southern Railway |
| Southern Indiana Railway | | MILW | 1897 | 1910 | Chicago, Terre Haute and Southeastern Railway |
| State Line and Covington Railroad | | C&EI | 1877 | 1877 | Chicago and Eastern Illinois Railroad |
| State Line and Indiana City Railway | | PRR | 1887 | 1901 | South Chicago and Southern Railroad |
| Sturgis, Goshen and St. Louis Railway | | NYC | 1889 | 1915 | New York Central Railroad |
| Syracuse and Milford Railway | | | 1907 | 1923 | N/A |
| Terre Haute and Alton Railroad | | NYC | 1851 | 1856 | Terre Haute, Alton and St. Louis Railroad |
| Terre Haute, Alton and St. Louis Railroad | | NYC | 1856 | 1862 | St. Louis, Alton and Terre Haute Railroad |
| Terre Haute, Brazil and Eastern Railroad | TBER | | 1987 | 1993 | N/A |
| Terre Haute and Indianapolis Railroad | | PRR | 1865 | 1905 | Vandalia Railroad |
| Terre Haute and Logansport Railroad | | PRR | 1879 | 1898 | Terre Haute and Logansport Railway |
| Terre Haute and Logansport Railway | | PRR | 1898 | 1905 | Vandalia Railroad |
| Terre Haute and Richmond Railroad | | PRR | 1847 | 1865 | Terre Haute and Indianapolis Railroad |
| Terre Haute and Southeastern Railroad | | NYC | 1878 | 1885 | Evansville and Indianapolis Railroad |
| Terre Haute, Worthington and Bloomfield Railway | | NYC | 1871 | 1879 | Terre Haute and Southeastern Railroad |
| Tiffin and Fort Wayne Railroad | | NKP | 1853 | 1859 | American Central Railway |
| Tippecanoe Railroad | TIPP | | 1980 | 1990 | J.K. Line, Inc. |
| Toledo, Cincinnati and St. Louis Railroad | | NKP | 1881 | 1884 | Bluffton, Kokomo and Southwestern Railroad |
| Toledo, Delphos and Burlington Railroad | | NKP | 1879 | 1882 | Toledo, Cincinnati and St. Louis Railroad |
| Toledo, Logansport and Burlington Railroad | | PRR | 1858 | 1862 | Toledo, Logansport and Burlington Railway |
| Toledo, Logansport and Burlington Railway | | PRR | 1862 | 1867 | Columbus and Indiana Central Railway |
| Toledo, Logansport and Northern Indiana Railroad | | PRR | 1863 | 1869 | Detroit, Logansport and St. Louis Railroad |
| Toledo, Peoria and Western Railroad | TPW | | 1976 | 1983 | Atchison, Topeka and Santa Fe Railway |
| Toledo, St. Louis and Kansas City Railroad | | NKP | 1886 | 1900 | Toledo, St. Louis and Western Railroad |
| Toledo, St. Louis and Western Railroad | | NKP | 1900 | 1923 | New York, Chicago and St. Louis Railroad |
| Toledo and Wabash Railway | | WAB | 1858 | 1865 | Toledo, Wabash and Western Railway |
| Toledo, Wabash and Western Railroad | | WAB | 1856 | 1858 | Wabash and Western Railway |
| Toledo, Wabash and Western Railway | | WAB | 1865 | 1876 | Wabash Railway |
| Twin Branch Railroad | TB | | 1925 | 1978 | N/A |
| Union and Logansport Railroad | | PRR | 1863 | 1867 | Columbus and Indiana Central Railway |
| Union Railroad, Transfer and Stock Yard Company | | NYC/ PRR | 1876 | 1881 | Belt Railroad and Stock Yard Company |
| Union Track Railway | | NYC/ PRR | 1850 | 1853 | Indianapolis Union Railway |
| Vandalia Railroad | | PRR | 1905 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Vernon, Greensburg and Rushville Railroad | | NYC | 1879 | 1938 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| Vincennes and Cairo Railroad | | NYC | 1871 | 1872 | Cairo and Vincennes Railroad |
| Wabash Railroad | WAB | WAB | 1942 | 1991 | Norfolk and Western Railway |
| Wabash Railroad | | WAB | 1899 | 1915 | Wabash Railway |
| Wabash Railroad | | C&EI | 1851 | 1853 | Evansville and Crawfordsville Railroad |
| Wabash Railway | | WAB | 1915 | 1942 | Wabash Railroad |
| Wabash Railway | | WAB | 1877 | 1879 | Wabash, St. Louis and Pacific Railway |
| Wabash Eastern Railway of Indiana | | WAB | 1889 | 1889 | Wabash Railroad |
| Wabash, St. Louis and Pacific Railway | | WAB | 1879 | 1886 | Cairo, Vincennes and Chicago Railway, Wabash Eastern Railway of Indiana |
| Wabash Western Railway | | WAB | 1887 | 1889 | Wabash Railroad |
| Wabash and Western Railway | | WAB | 1858 | 1858 | Toledo and Wabash Railway |
| Warsaw, Goshen and White Pigeon Railroad | | NYC | 1870 | 1871 | Cincinnati, Wabash and Michigan Railway |
| Western Division, Buffalo and Mississippi Railroad | | NYC | 1848 | 1855 | Northern Indiana Railroad |
| Western Indiana Railroad | | C&EI | 1872 | 1872 | Chicago, Danville and Vincennes Railroad |
| Western Indiana Railway | | EJE | | 1897 | Chicago Heights and Northern Railway |
| White River Railway | | | 1901 | | |
| White Water Railroad | | NYC | 1878 | 1890 | Cleveland, Cincinnati, Chicago and St. Louis Railway |
| White Water Valley Railroad | | NYC | 1865 | 1878 | White Water Railroad |
| Winona Railroad | | | 1926 | 1952 | N/A | Electric until 1938 |
