Bucolome

Bucolome

Clinical data
Other names	Bucolome, Paramidine
AHFS/Drugs.com	International Drug Names
ATC code	none
Identifiers
IUPAC name 5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
CAS Number	841-73-6
PubChem CID	2461
ChemSpider	2367  Y
UNII	9T08RAL174
ChEBI	CHEBI:31314  Y
ChEMBL	ChEMBL2106136
CompTox Dashboard (EPA)	DTXSID4048854
ECHA InfoCard	100.011.515
Chemical and physical data
Formula	C14H22N2O3
Molar mass	266.341 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCC1C(=O)NC(=O)N(C1=O)C2CCCCC2
InChI InChI=1S/C14H22N2O3/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10/h10-11H,2-9H2,1H3,(H,15,17,19) Y Key:DVEQCIBLXRSYPH-UHFFFAOYSA-N Y
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Bucolome (Paramidine) is a barbiturate derivative. Unlike most barbiturates it does not have any significant sedative or hypnotic effects, but instead acts as an analgesic and antiinflammatory. It also acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites. ^{[1] [2] [3]}

References

1. Takamura N, Maruyama T, Chosa E, Kawai K, Tsutsumi Y, Uryu Y, et al. (April 2005). "Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome". Drug Metabolism and Disposition. 33 (4): 596–602. CiteSeerX   10.1.1.658.6194 . doi:10.1124/dmd.104.002782. PMID   15640375. S2CID   1184330.
2. Osawa M, Hada N, Matsumoto K, Hasegawa T, Kobayashi D, Morimoto Y, et al. (April 2005). "Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions". International Journal of Pharmaceutics. 293 (1–2): 43–9. doi:10.1016/j.ijpharm.2004.12.009. PMID   15778043.
3. Kobayashi M, Takagi M, Fukumoto K, Kato R, Tanaka K, Ueno K (2008). "The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan". Drug Metabolism and Pharmacokinetics. 23 (2): 115–9. doi: 10.2133/dmpk.23.115 . PMID   18445991.