This article is an autobiography or has been extensively edited by the subject or by someone connected to the subject.(May 2021) |
P. K. Rajagopalan | |
---|---|
Born | 1930/10/27 |
Died | 29/04/2024 Chennai |
Resting place | Chennai |
Other names | Pylore Krishnaier Rajagopalan |
Occupation(s) | Vector control scientist, acarologist |
Years active | 1952-1990 |
Known for | Vector Control programme in India |
Awards | Padma Shri Om Prakash Bhasin Award |
Pylore Krishnaier Rajagopalan was an Indian vector control scientist, biologist and acarologist, known for his pioneering contributions to the control programmes against vector-borne diseases in India. [1] He was a former director of the Indian Council of Medical Research managed Vector Control Research Centre, Pondicherry. [2] [3] He graduated in 1949 from the Banaras Hindu University and obtained a Masters in Zoology with University First Rank there itself in 1951. [4] In 1952 he joined the fledgling Virus Research Centre in Pune, and worked under the supervision of some of the finest vector control specialists such as Dr T Ramachandra Rao. [5] In recognition of his outstanding work as a young research scientist, in 1957 he was awarded a Fellowship by the Rockefeller Foundation to pursue a Master's program in Public Health from the University of California. [6] He went on to secure a Diploma in Acarology from the University of Maryland at College Park. [7]
He returned to India in 1960 and rejoined the Virus Research Centre where he was asked to lead the investigation into the mysterious Kyasanur Forest Disease in rural Karnataka. [8] His pioneering work on the role of migratory birds in spreading disease vectors as part of the investigation into KFD, conducted under the supervision of the ornithologist the late Dr Salim Ali, led to his doctoral degree from Pune University. [9]
He was then assigned as a Senior Scientist to the World Health Organization Project on Genetic Control of Mosquitoes in New Delhi, during which time he expanded the body of knowledge on mosquito population behaviour. [10] In 1975 he was posted to Pondicherry where he founded the Vector Control Research Centre - a research centre set up to study ecological control of vector borne diseases. [11]
The VCRC, under his leadership, contributed significantly to the control of Japanese Encephalitis in Burdwan District. [12] However its flagship achievement under the leadership of Dr Rajagopalan was to pioneer the technique of Biological Control, which combined minimal chemical intervention with environmental measures and the use of natural mosquito larval predators to bring down the incidence of diseases like filariasis. This was demonstrated spectacularly over five years in Pondicherry and Shertallai in Kerala. [13]
After his superannuation in 1990, he served the World Health Organization as a member of their steering committees on Filariasis and on biological control of vectors. [14] He is a fellow of the Royal Society of Tropical Medicine, UK [2] and is credited with several articles on vector control and acarology. [15] [16]
Dr Rajagopalan has worked extensively on ecological aspects of vector borne diseases for four decades on a variety of diseases in India. His academic interests are:
Dr Rajagopalan has continuously kept himself abreast with the body of knowledge in vector biology. He has received extensive training on arboviruses from 406th SEATO research Centre, Bangkok, at the National Institutes of Health, Tokyo, at the Trinidad Regional Virus Laboratory, Port-of-Spain and at the East African Virus Laboratory in Entebbe in Uganda. [24] He sharpened his knowledge of Malaria vector control at the Malaria Research Institute, Amani in Tanzania and on mosquito taxonomy from P. F. Mattingly at the British Museum (Natural History), London. [25] He had the privilege of learning Ecology under Charles Elton at Bureau of Animal Populations, Oxford, and Acarology under Dr Hoogstraal, US Naval Medical Research Unit in Cairo during his career. [26] He was associated with Dr Jorge Boshell and many others of the Rockefeller Foundation for two decades. [27] In recognition of his body of scientific work, he was honoured with a Padma Shri by President R Venkataraman in 1990. [28]
Mosquitoes, the Culicidae, are a family of small flies consisting of 3,600 species. The word mosquito is Spanish and Portuguese for little fly. Mosquitoes have a slender segmented body, one pair of wings, three pairs of long hair-like legs, and specialized, highly elongated, piercing-sucking mouthparts. All mosquitoes drink nectar from flowers; females of some species have in addition adapted to drink blood. The group diversified during the Cretaceous period. Evolutionary biologists view mosquitoes as micropredators, small animals that parasitise larger ones by drinking their blood without immediately killing them. Medical parasitologists view mosquitoes instead as vectors of disease, carrying protozoan parasites or bacterial or viral pathogens from one host to another.
Filariasis, is a filarial infection caused by parasitic nematodes (roundworms) spread by different vectors. They are included in the list of neglected tropical diseases.
Arbovirus is an informal name for any virus that is transmitted by arthropod vectors. The term arbovirus is a portmanteau word. Tibovirus is sometimes used to more specifically describe viruses transmitted by ticks, a superorder within the arthropods. Arboviruses can affect both animals and plants. In humans, symptoms of arbovirus infection generally occur 3–15 days after exposure to the virus and last three or four days. The most common clinical features of infection are fever, headache, and malaise, but encephalitis and viral hemorrhagic fever may also occur.
Culex or typical mosquitoes are a genus of mosquitoes, several species of which serve as vectors of one or more important diseases of birds, humans, and other animals. The diseases they vector include arbovirus infections such as West Nile virus, Japanese encephalitis, or St. Louis encephalitis, but also filariasis and avian malaria. They occur worldwide except for the extreme northern parts of the temperate zone, and are the most common form of mosquito encountered in some major U.S. cities, such as Los Angeles.
Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. Usually acquired in childhood, it is a leading cause of permanent disability worldwide, impacting over a hundred million people and manifesting itself in a variety of severe clinical pathologies While most cases have no symptoms, some people develop a syndrome called elephantiasis, which is marked by severe swelling in the arms, legs, breasts, or genitals. The skin may become thicker as well, and the condition may become painful. Affected people are often unable to work and are often shunned or rejected by others because of their disfigurement and disability.
The discipline of medical entomology, or public health entomology, and also veterinary entomology is focused upon insects and arthropods that impact human health. Veterinary entomology is included in this category, because many animal diseases can "jump species" and become a human health threat, for example, bovine encephalitis. Medical entomology also includes scientific research on the behavior, ecology, and epidemiology of arthropod disease vectors, and involves a tremendous outreach to the public, including local and state officials and other stake holders in the interest of public safety.
Avian malaria is a parasitic disease of birds, caused by parasite species belonging to the genera Plasmodium and Hemoproteus. The disease is transmitted by a dipteran vector including mosquitoes in the case of Plasmodium parasites and biting midges for Hemoproteus. The range of symptoms and effects of the parasite on its bird hosts is very wide, from asymptomatic cases to drastic population declines due to the disease, as is the case of the Hawaiian honeycreepers. The diversity of parasites is large, as it is estimated that there are approximately as many parasites as there are species of hosts. As research on human malaria parasites became difficult, Dr. Ross studied avian malaria parasites. Co-speciation and host switching events have contributed to the broad range of hosts that these parasites can infect, causing avian malaria to be a widespread global disease, found everywhere except Antarctica.
The London Underground mosquito, Culex pipiens f. molestus, is a form of mosquito which assaulted people sleeping in the London Underground railway system during the Blitz. It has a worldwide distribution and long predates the existence of the London Underground. It was first described in the 18th century based on Egyptian specimens by the biologist Peter Forsskål (1732–1763). He named it Culex molestus due to its voracious biting, but later biologists reclassified it as Culex pipiens f. molestus because there were no morphological differences between it and Culex pipiens.
Culex pipiens is a species of mosquito commonly referred to as the common house mosquito or northern house mosquito. Native to Africa, Asia and Europe, it is now widely distributed in temperate regions on every continent except Antarctica and is one of the most common mosquitoes found in human habitats in temperate parts of the northern hemisphere. A major vector of some viruses, it can be abundant in cities, especially those with poor wastewater management. It is the most common mosquito to the northern regions of the US. Culex pipiens is the type species for the genus Culex.
Culex restuans is a species of mosquito known to occur in Canada, the United States, Mexico, Guatemala, Honduras, and the Bahamas. It is a disease vector for St. Louis encephalitis and West Nile virus. In 2013 West Nile Virus positive specimens were collected in Southern California.
Mandayam Osuri Tirunarayana Iyengar was an Indian medical entomologist who worked on management of filaria and malaria vectors. He was employed as an entomologist in the Department of Malaria Research, Bengal. The mermithid parasite Romanomermis iyengari and the mosquito species Culex iyengari are named after him.
Mosquito-borne diseases or mosquito-borne illnesses are diseases caused by bacteria, viruses or parasites transmitted by mosquitoes. Nearly 700 million people contract mosquito-borne illnesses each year, resulting in more than a million deaths.
Culex quinquefasciatus, commonly known as the southern house mosquito, is a medium-sized mosquito found in tropical and subtropical regions of the world. It is a vector of Wuchereria bancrofti, avian malaria, and arboviruses including St. Louis encephalitis virus, Western equine encephalitis virus, Zika virus and West Nile virus. It is taxonomically regarded as a member of the Culex pipiens species complex. Its genome was sequenced in 2010, and was shown to have 18,883 protein-coding genes.
Rajpal Singh Yadav is an Indian scientist in the field of vector ecology and management. He joined the World Health Organization in 2009. He retired in 2023, as a Scientist at the Department of Control of Neglected Tropical Diseases, Geneva, Switzerland. He was a Co-Chair of the WHO Joint Action Group for the implementation of the Global Vector Control Response,. He was also Head of the WHO Pesticide Evaluation Scheme (WHOPES) for the evaluation of vector control products. During this period he reviewed research protocols and generated a global evidence base for insecticide use and pesticide management. He was also a Focal person in, the WHO secretariat for the FAO/WHO Joint Programme on Pesticide Management. The work involved collaboration with other UN and international organizations, research institutions, programmes, industry, NGOs, and other stakeholders. He is the recipient of the 2016, Lifetime Achievement Award from the Indian Association of Entomologists. He has published more than 100 scientific articles in peer-reviewed journals.
Mosquito-malaria theory was a scientific theory developed in the latter half of the 19th century that solved the question of how malaria was transmitted. The theory proposed that malaria was transmitted by mosquitoes, in opposition to the centuries-old medical dogma that malaria was due to bad air, or miasma. The first scientific idea was postulated in 1851 by Charles E. Johnson, who argued that miasma had no direct relationship with malaria. Although Johnson's hypothesis was forgotten, the arrival and validation of the germ theory of diseases in the late 19th century began to shed new lights. When Charles Louis Alphonse Laveran discovered that malaria was caused by a protozoan parasite in 1880, the miasma theory began to subside.
Mansonia (Mansonioides) annulifera is a species of zoophilic mosquito belonging to the genus Mansonia.
Haemaphysalis aculeata is a hard-bodied tick of the genus Haemaphysalis. It is found in India and Sri Lanka.
Haemaphysalis spinigera, is a hard-bodied tick of the genus Haemaphysalis. It is found in India, Sri Lanka, Vietnam. It is an obligate ectoparasite of mammals of various rodents, insectivores and monkeys. It is a potential vector of Kyasanur Forest disease virus, and Kaisodi virus.
Lymphatic filariasis in India refers to the presence of the disease lymphatic filariasis in India and the social response to the disease. In India, 99% of infections come from a type of mosquito spreading a type of worm through a mosquito bite. The treatment plan provides 400 million people in India with medication to eliminate the parasite. About 50 million people in India were carrying the worm as of the early 2010s, which is 40% of all the cases in the world. In collaboration with other countries around the world, India is participating in a global effort to eradicate lymphatic filariasis. If the worm is eliminated from India then the disease could be permanently eradicated. In October 2019 the Union health minister Harsh Vardhan said that India's current plan is on schedule to eradicate filariasis by 2021.