Sodium/hydrogen exchanger 5

SLC9A5
Identifiers
Aliases	SLC9A5 , NHE5, solute carrier family 9 member A5
External IDs	OMIM: 600477 MGI: 2685542 HomoloGene: 31247 GeneCards: SLC9A5
Gene location (Human)
Chr.	Chromosome 16 (human) [1]
End	67,272,191 bp [1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse) [2]
End	105,369,881 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• solute:proton antiporter activity ; • antiporter activity ; • potassium:proton antiporter activity ; • sodium:proton antiporter activity ;
Cellular component	• membrane ; • integral component of membrane ; • cell membrane ;
Biological process	• regulation of pH ; • ion transport ; • hydrogen ion transmembrane transport ; • sodium ion transport ; • cation transport ; • regulation of intracellular pH ; • sodium ion import across plasma membrane ; • potassium ion transmembrane transport ; • transmembrane transport ; • anion transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	6553
	277973
	ENSG00000135740
	ENSMUSG00000014786
	Q14940
	B2RXE2
NM_004594 ; NM_001323971 ; NM_001323972 ; NM_001323973 ; NM_001323974 ;
	NM_001323975
	NM_001081332
NP_001310900 ; NP_001310901 ; NP_001310902 ; NP_001310903 ; NP_001310904 ;
	NP_004585
	NP_001074801
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 19, 2020

Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.^[5]^[6]^[7]

Related Research Articles

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 gene.

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.

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Electroneutral sodium bicarbonate exchanger 1 protein-coding gene in the species Homo sapiens

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.

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Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.

Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 gene. It was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes.

Solute carrier family 6, member 20 also known as SLC6A20 is a protein which in humans is encoded by the SLC6A20 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135740 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014786 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.
↑ Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi: 10.1074/jbc.274.7.4383 . PMID 9933642.
↑ "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain". J. Biol. Chem. 274 (7): 4377–82. doi: 10.1074/jbc.274.7.4377 . PMID 9933641.
Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton". J. Biol. Chem. 277 (45): 42623–32. doi: 10.1074/jbc.M206629200 . PMID 12205089.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590 . PMID 12417987.
Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi: 10.1248/bpb.26.148 . PMID 12576672.
Lin WM, Chen XH, Xu R, et al. (2003). "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao : [Acta Physiologica Sinica]. 55 (1): 79–82. PMID 12598940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790–5. doi:10.1073/pnas.0407444102. PMC 549460 . PMID 15699339.
Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity". Cell. Signal. 19 (1): 194–203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135740 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014786 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7759094-5] Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.

[pmid9933642-6] Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi: 10.1074/jbc.274.7.4383 . PMID 9933642.

[entrez-7] "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

Sodium/hydrogen exchanger 5

Contents

See also

Related Research Articles

References

Further reading